The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Immunohistochemical characteristics of melanoma
Open accessAbstract
Melanoma has a wide spectrum of histologic features which mimic epithelial, hematologic, mesenchymal, and neural tumors. Immunohistochemistry has been the primary tool to distinguish melanomas from these other tumors; it has also been studied for use as an adjunct to distinguish benign and malignant melanocytic tumors and to elucidate prognosis. Furthermore, there has been extensive effort to find a suitable marker to differentiate spindle cell and desmoplastic melanoma from other tumors. We have reviewed the literature investigating melanocytic differentiation markers, proliferation markers, immunomodulatory markers, signaling molecules, and nerve growth factors and receptors. Despite the proliferation of immunohistochemical markers, S‐100 remains the most sensitive marker for melanocytic lesions, while markers such as HMB‐45, MART‐1/Melan‐A, tyrosinase, and MITF demonstrate relatively good specificity but not as good sensitivity as S‐100. No marker has proven useful in distinguishing spindle cell and desmoplastic melanomas from other tumors. Ki67 remains the most useful adjunct in distinguishing benign from malignant melanocytic tumors. None of the markers reviewed has been shown conclusively to have prognostic value for melanocytic neoplasms.
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PEComa: what do we know so far?
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Progression in Cutaneous Malignant Melanoma Is Associated with Distinct Expression Profiles
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Final Version of 2009 AJCC Melanoma Staging and Classification
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Self-citationhttp://www.avensonline.org/fulltextarticles/JSUR-2332-4139-S1-0001.html
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MDM4 is a key therapeutic target in cutaneous melanoma
Gembarska, A., Luciani, F., Fedele, C., Russell, E. A., Dewaele, M., Villar, S., Zwolinska, A., Haupt, S., de Lange, J., Yip, D., et al. (2012) · Nature Medicine · doi:10.1038/nm.2863 · Cited by 327
Bacchi, C. E., Wludarski, S. C., Ambaye, A. B., Lamovec, J., Salviato, T., & Falconieri, G. (2013) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2011-0552-oa · Cited by 37
Digital quantification of Ki67 and PRAME in challenging melanocytic lesions—A novel diagnostic tool
Brogård, M. B., Steiniche, T., Lade-Keller, J., Wandler, A., Christensen, K. B., Georgsen, J. B., & Nielsen, P. S. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.155953 · Cited by 1
Metadata
- Authors
- Ohsie, S. J., Sarantopoulos, G. P., Cochran, A. J., & Binder, S. W.
- Venue
- Journal of Cutaneous Pathology
- Publisher
- Wiley
- Published
- 2008-04-08
- Volume
- 35
- Issue
- 5
- Pages
- 433-444
- ISSN
- 0303-6987 (ISSN-L)
- 1600-0560
- OpenAlex
- W2112642558
- Cited by
- 593
- References
- 56
- FWCI
- 21.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ohsie, S. J., Sarantopoulos, G. P., Cochran, A. J., & Binder, S. W. (2008). Immunohistochemical characteristics of melanoma. Journal of Cutaneous Pathology. https://doi.org/10.1111/j.1600-0560.2007.00891.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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