An intestinal receptor for heme
Abstract
Porcine upper small intestine took up radioactive heme in vitro. The binder was localised to the brush borders, was solubilized with Triton X-100 and bound heme with high affinity. The binding was inhibited with non-radioactive heme but not with FeSO4, and control experiments indicated that it was not any of the known heme binders or aggregated heme. The binding factor could also be solubilized from human duodenum.
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Heme-conjugated iron is absorbed by enterocytes in the duodenum, although this heme importer has not yet been characterized.
“It has also been demonstrated that heme-conjugated iron is absorbed by enterocytes in the duodenum although this heme importer has not yet been characterized (Gräsbeck et al., 1979).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Gräsbeck et al., 1979
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- Authors
- Gräsbeck, R., Kouvonen, I., Lundberg, M., & Tenhunen, R.
- Affiliations
- University of Helsinki (FI)
- Corresponding author
- Gräsbeck, Ralph
- Venue
- Scandinavian Journal of Haematology
- Publisher
- Wiley
- Published
- 1979-07
- Volume
- 23
- Issue
- 1
- Pages
- 5-9
- ISSN
- 0036-553X (ISSN-L)
- OpenAlex
- W2172298742
- Cited by
- 84
- References
- 12
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 1 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Haematology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
- Keywords
- brush border, porcine small intestine, duodenum, heme binding, Triton X-100 solubilization
- MeSH terms
- Animals, Chromatography, Gel, Heme, Humans, Intestinal Mucosa, Intestine, Small, Microvilli, Polyethylene Glycols, Receptors, Drug, Swine
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