Development of polycythaemia vera in a patient with myelofibrosis
Abstract
In March 1981, a 53‐year‐old man presented with itching and was diagnosed as having myelofibrosis. There was gradual enlargement of the spleen over the following 5 yr. His spleen had to be removed in February 1986 because of physical discomfort. 3 months post‐splenectomy he became polycythaemic. Bone marrow examination was consistent with severe myelofibrosis. It was possible to demonstrate erythropoietin‐independent BFU‐E from peripheral blood, and ferrokinetic studies showed that erythropoiesis was localised to the liver with little bone marrow activity. Thus, despite severe marrow fibrosis, liver erythropoiesis was now polycythaemic, suggesting the coexistence of myelofibrosis and polycythaemia vera.
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Heritability accounts for 50-75% of the risk for nicotine dependence, depending on how dependence is defined and which population is studied.
“Depending on the parameters used to define dependence, and the population considered, heritability contributes 50–75 % of the risk for dependence (Dokal et al. 1989; Hall et al. 2002; Lessov et al. 2004; Furberg et al. 2010; Nugent et al. 2014; also see chapters entitled Genetics of Smoking Behaviour and Pharmacogenetics of Nicotine and Associated Smoking Behaviors; volume 23).”
From Nicotine Withdrawal (2015) · cites this paper as Dokal et al. 1989
Cites
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Polycythemia vera: its course and treatment; relation to myeloid metaplasia and leukemia.
Wasserman, L. R. (1954) · PubMed · Cited by 105 · see citing works
Transitional Myeloproliferative Disorder
Pettit, J. E., Lewis, S. M., & Nicholas, A. W. (1979) · British Journal of Haematology · doi:10.1111/j.1365-2141.1979.tb03739.x · Cited by 64 · see citing works
Self-citationSplenic irradiation in myelofibrosis. Clinical findings and ferrokinetics
Parmentier, C., Charbord, P., Tibi, M., et al. (1977) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(77)90112-2 · Cited by 44 · see citing works
Splenic Hematopoiesis in Polycythemia Vera: A Morphologic and Immunohistologic Study
Wolf, B. C., Banks, P. M., Mann, R. B., et al. (1988) · American Journal of Clinical Pathology · doi:10.1093/ajcp/89.1.69 · Cited by 39 · see citing works
Patho-anatomical Features of the Spleen and Liver
Söderström, N., Bandmann, U., & LUNDH, B. (1975) · Clinics in Haematology · doi:10.1016/s0308-2261(21)00078-3 · Cited by 24 · see citing works
Lopas, H. (1964) · Archives of Internal Medicine · doi:10.1001/archinte.1964.03860120066004 · Cited by 23 · see citing works
Polycythaemia Vera — Transformation to Myelofibrosis and Subsequent Reversal
Pettit, J. E., Lewis, S. M., & Goolden, A. W. G. (1978) · Scandinavian Journal of Haematology · doi:10.1111/j.1600-0609.1978.tb01555.x · Cited by 17 · see citing works
Self-citationTransition of Myelofibrosis to Polycythaemia Vera
Hasselbalch, H. C., & Berild, D. (1983) · Scandinavian Journal of Haematology · doi:10.1111/j.1600-0609.1983.tb01464.x · Cited by 15 · see citing works
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McLaughlin, I., Dani, J. A., & De Biasi, M. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/978-3-319-13482-6_4 · Cited by 173 · see citing works
“Depending on the parameters used to define dependence, and the population considered, heritability contributes 50–75 % of the risk for dependence (Dokal et al. 1989; Hall et al. 2002; Lessov et al. 2004; Furberg et al. 2010; Nugent et al. 2014; also see chapters entitled Genetics of Smoking…”
Method
- Authors
- Dokal, I., Pagliuca, A., Deenmamode, M., Mufti, G. J., & Lewis, S. M.
- Affiliations
- Hammersmith Hospital (GB)
- Corresponding author
- Dokal, I.
- Venue
- European Journal of Haematology
- Publisher
- Wiley
- Published
- 1989-01
- Volume
- 42
- Issue
- 1
- Pages
- 96-98
- ISSN
- 0902-4441 (ISSN-L)
- 1600-0609
- OpenAlex
- W1983869774
- Cited by
- 6
- References
- 10
- Citations by year
- 2023: 1 · 2015: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal Of Haematology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Genetics › Myeloproliferative Neoplasms: Diagnosis and Treatment
- Health Sciences › Medicine › Emergency Medicine › Hematological disorders and diagnostics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Keywords
- polycythemia vera, myelofibrosis, splenomegaly, splenectomy, BFU-E, ferrokinetic studies, bone marrow fibrosis
- MeSH terms
- Bone Marrow, Erythropoiesis, Humans, Iron Radioisotopes, Liver, Male, Middle Aged, Polycythemia, Radionuclide Imaging, Splenomegaly, Primary Myelofibrosis
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