Fluorescence induction of protoporphyrin IX by a new 5‐aminolevulinic acid nanoemulsion used for photodynamic therapy in a full‐thickness ex vivo skin model
Abstract
Please cite this paper as: Fluorescence induction of protoporphyrin IX by a new 5‐aminolevulinic acid nanoemulsion used for photodynamic therapy in a full‐thickness ex vivo skin model. Experimental Dermatology 2010; 19: e302–e305. Abstract: An ex vivo porcine skin model was utilized to analyse the penetration of 5‐aminolevulinic acid (5‐ALA) contained in a nanoemulsion‐based formulation BF‐200 ALA (10% 5‐ALA‐hydrochloride) versus 16% aminolevulinate methyl ester‐hydrochloride in a commercially cream (MAL cream) by fluorescence microscopy of their common metabolite protoporphyrin IX (PpIX) after 3, 5, 8 and 12 h. Fluorescence signals of PpIX in pig skin treated with BF‐200 ALA were stronger than those for MAL cream. At 8 and 12 h, the PpIX fluorescence signals were 4.8‐ and 5.0‐fold higher than those measured after MAL cream application. Fluorescence signals of PpIX after application of BF‐200 ALA were detected in deeper tissue layers of the epidermis than after application of MAL cream (97.2 ± 5.7 μ m for BF‐200 ALA vs 42.0 ± 4.2 μ m for MAL cream). These data implicate that BF‐200 ALA in photodynamic therapy might lead to a superior therapeutically effect of intraepidermal (in situ) squamous cell carcinomas.
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BF-200 ALA leads to much stronger PpIX fluorescence than MAL cream and induces fluorescence at a tissue depth more than twice that achieved with MAL cream.
“The resulting ALA nano-emulsion with 10% ALA hydrochloride (BF-200 ALA) not only leads to much stronger PpIX fluorescence than that by MAL cream but also induces fluorescence at a tissue depth of more than twice as much as that achieved with MAL cream.”
From 5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy (2023) · cites this paper as [22]
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- Authors
- Maisch, T., Santarelli, F., Schreml, S., Babilas, P., & Szeimies, R.
- Affiliations
- University Hospital Regensburg (DE)
- Corresponding author
- Maisch, Tim
- Venue
- Experimental Dermatology
- Publisher
- Wiley
- Published
- 2010-07-21
- Volume
- 19
- Issue
- 8
- Pages
- e302-5
- ISSN
- 0906-6705 (ISSN-L)
- 1600-0625
- OpenAlex
- W1606341412
- Cited by
- 83
- References
- 15
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 7 · 2021: 6 · 2020: 9 · 2019: 4 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 5 · 2014: 1 · 2013: 4 · 2012: 5
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Dermatology (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Keywords
- 5-aminolevulinic acid, nanoemulsions, protoporphyrin IX, photodynamic therapy, topical formulation, skin penetration, squamous cell carcinoma, fluorescence imaging, epidermis
- MeSH terms
- Administration, Topical, Aminolevulinic Acid, Animals, Emulsions, Fluorescence, Photochemotherapy, Protoporphyrins, Skin, Skin Absorption, Swine, Models, Animal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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