Differential expression of antimicrobial peptides in margins of chronic wounds
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Please cite this paper as: Differential expression of antimicrobial peptides in margins of chronic wounds. Experimental Dermatology 2010; 19: 628–632. Abstract: Skin wounds usually heal without major infections, although the loss of the mechanical epithelial barrier exposes the tissue to various bacteria. One reason may be the expression of antimicrobial peptides (AMP) of which some [human β‐defensins (hBD) and LL‐37] were recently shown to support additionally certain steps of wound healing. There are no studies which have compared expression patterns of different classes of AMP in chronic wounds. The aim of our study was therefore to analyse the expression profile of hBD‐2, hBD‐3, LL‐37, psoriasin and RNase 7 by immunohistochemistry from defined wound margins of chronic venous ulcers. We detected a strong induction of psoriasin and hBD‐2 in chronic wounds in comparison with healthy skin. Except for stratum corneum, no expression of RNase 7 and LL‐37 was detected in the epidermis while expression of hBD‐3 was heterogeneous. Bacterial swabs identified Staphylococcus aureus and additional bacterial populations, but no association between colonization and AMP expression was found. The differential expression of AMP is noteworthy considering the high bacterial load of chronic ulcers. Clinically, supplementation of AMP with the capability to enhance wound healing besides restricting bacterial overgrowth could present a physiological support for treatment of disturbed wound healing.
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In contrast, expression of other AMPs, such as S100A7, ribonuclease 7, hBD2, and hBD3, is not reduced in chronic wounds, but remains unchanged or is upregulated.
“In contrast, expression of other AMPs, such as S100A7, ribonuclease 7 (RNase7), hBD2, and hBD3, is not reduced in chronic wounds, but remains unchanged or is upregulated.44”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [44]
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The Innate Immune System in Acute and Chronic Wounds
MacLeod, A. S., & Mansbridge, J. N. (2016) · Advances in Wound Care · doi:10.1089/wound.2014.0608 · Cited by 289 · see citing works
“In contrast, expression of other AMPs, such as S100A7, ribonuclease 7 (RNase7), hBD2, and hBD3, is not reduced in chronic wounds, but remains unchanged or is upregulated.(44) S100 proteins comprise a large family of lowmolecular-weight proteins that are characterized by the presence of calcium-binding EF-hands.”
BackgroundInnate and Adaptive Immune Responses in Wound Epithelialization
Strbo, N., Yin, N., & Stojadinovic, O. (2014) · Advances in Wound Care · doi:10.1089/wound.2012.0435 · Cited by 200 · see citing works
- Authors
- Dressel, S., Harder, J., Cordes, J., Wittersheim, M., Meyer‐Hoffert, U., Sunderkötter, C., & Gläser, R.
- Affiliations
- University Hospital Schleswig-Holstein (DE)
- University of Münster (DE)
- Corresponding author
- Sunderkötter, Cord
- Venue
- Experimental Dermatology
- Publisher
- Wiley
- Published
- 2010-06-14
- Volume
- 19
- Issue
- 7
- Pages
- 628-632
- ISSN
- 0906-6705 (ISSN-L)
- 1600-0625
- OpenAlex
- W1801159412
- Cited by
- 63
- References
- 23
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 7 · 2013: 7 · 2012: 5
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Experimental Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Keywords
- antimicrobial peptides, chronic wounds, venous leg ulcers, wound margin, human beta-defensins, human beta-defensin 2, human beta-defensin 3, LL-37, psoriasin, RNase 7, Staphylococcus aureus, bacterial colonization, wound healing, epidermis
- MeSH terms
- S100 Calcium Binding Protein A7, Aged, Humans, Immunohistochemistry, Male, Middle Aged, S100 Proteins, Ribonucleases, Staphylococcal Skin Infections, Varicose Ulcer, Wounds and Injuries, Gene Expression Profiling, beta-Defensins, Antimicrobial Cationic Peptides, Cathelicidins
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