The expression of microRNA‐203 during human skin morphogenesis
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Please cite this paper as: The expression of microRNA‐203 during human skin morphogenesis. Experimental Dermatology 2010; 19: 854–856. Abstract: MicroRNAs are small, non‐coding RNAs that regulate gene expression post‐transcriptionally and play important roles in various biological processes. We previously identified miR‐203 as a skin‐ and keratinocyte‐specific microRNA. Moreover, miR‐203 has been implicated in repressing ‘stemness’ in epidermal progenitors. Here, we investigate the expression of miR‐203 and two of its targets, p63 and suppressor of cytokine signalling‐3, during human skin morphogenesis. MiR‐203 in situ hybridization was performed on sections of human foetal skin ranging from 14 to 22 weeks’ gestation and adult skin. MiR‐203 was barely detectable at 14 weeks. Its expression became prominent from week 17 and was most pronounced in the suprabasal layers of the epidermis, while p63 and SOCS‐3 were preferentially expressed in the basal layer. Differentiation markers such as involucrin and filaggrin were expressed mainly in the suprabasal layers of epidermis, similar to miR‐203. Our results support the involvement of miR‐203 in skin morphogenesis.
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SOCS3 is an evolutionarily conserved target of miR-203.
“Since SOCS3 is an evolutionarily conserved target of miR-203 (26)”
From A20 promotes liver regeneration by decreasing SOCS3 expression to enhance IL-6/STAT3 proliferative signals (2013) · cites this paper as [26]
A20-mediated modulation of SOCS3 expression in hepatocytes is at least in part epigenetically regulated by A20's effect on miR-203.
“Since SOCS3 is an evolutionarily conserved target of miR-203 (26), A20-mediated modulation of SOCS3 expression in hepatocytes is, at least in part, epigenetically regulated by A20’s effect on miR-203.”
From A20 promotes liver regeneration by decreasing SOCS3 expression to enhance IL-6/STAT3 proliferative signals (2013) · cites this paper as [26]
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Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs
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da Silva, C. G., Studer, P., Skroch, M., Mahiou, J., Minussi, D. C., Peterson, C. R., Wilson, S. W., Patel, V. I., Ma, A., Csizmadia, E., et al. (2013) · Hepatology · doi:10.1002/hep.26197 · Cited by 77 · see citing works
Epidermal Stem Cells and Their Epigenetic Regulation
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- Authors
- Wei, T., Orfanidis, K., Xu, N., Janson, P., Ståhle, M., Pivarcsi, A., & Sonkoly, E.
- Affiliations
- Karolinska Institutet (SE)
- University of Szeged (HU)
- Corresponding author
- Wei, Tianling
- Venue
- Experimental Dermatology
- Publisher
- Wiley
- Published
- 2010-08-12
- Volume
- 19
- Issue
- 9
- Pages
- 854-856
- ISSN
- 0906-6705 (ISSN-L)
- 1600-0625
- OpenAlex
- W2158778299
- Cited by
- 60
- References
- 4
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 6 · 2019: 2 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 5 · 2013: 1 · 2012: 8
- FWCI
- 9.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Experimental Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Psoriasis Foundation
- Psoriasis Association
- Karolinska Institutet
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Keywords
- miR-203, microRNA, skin morphogenesis, epidermis, p63, SOCS3, keratinocytes, epidermal differentiation, involucrin, filaggrin, fetal skin development, suprabasal layer, basal layer, post-transcriptional regulation
- MeSH terms
- Filaggrin Proteins, Humans, Morphogenesis, Skin, MicroRNAs
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