SOCS3 Is a Physiological Negative Regulator for Granulopoiesis and Granulocyte Colony-stimulating Factor Receptor Signaling

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SOCS Proteins: Negative Regulators of Cytokine Signaling

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IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

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Negative Regulation of Cytokine Signaling Pathways

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Cis3/Socs3/Ssi3 Plays a Negative Regulatory Role in Stat3 Activation and Intestinal Inflammation

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Cytokine‐inducible SH2 protein‐3 (CIS3/SOCS3) inhibits <i>Janus</i> tyrosine kinase by binding through the N‐terminal kinase inhibitory region as well as SH2 domain

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SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis

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CIS3/SOCS-3 Suppresses Erythropoietin (EPO) Signaling by Binding the EPO Receptor and JAK2

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Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

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Characterization of a novel EGFP reporter mouse to monitor Cre recombination as demonstrated by a Tie2 Cre mouse line

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Opposing roles of STAT1 and STAT3 in T cell–mediated hepatitis: regulation by SOCS

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Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor

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STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation

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Interleukin-10 (IL-10) Selectively Enhances CIS3/SOCS3 mRNA Expression in Human Neutrophils: Evidence for an IL-10–Induced Pathway That Is Independent of STAT Protein Activation

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SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation

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Distinct regions of the granulocyte colony-stimulating factor receptor are required for tyrosine phosphorylation of the signaling molecules JAK2, Stat3, and p42, p44MAPK.

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Multiple signaling pathways induced by granulocyte colony-stimulating factor involving activation of JAKs, STAT5, and/or STAT3 are required for regulation of three distinct classes of immediate early genes

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Jak1 Plays an Essential Role for Receptor Phosphorylation and Stat Activation in Response to Granulocyte Colony-Stimulating Factor

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“Emergency” granulopoiesis in G-CSF–deficient mice in response to Candida albicans infection

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Sustained Receptor Activation and Hyperproliferation in Response to Granulocyte Colony-stimulating Factor (G-CSF) in Mice with a Severe Congenital Neutropenia/Acute Myeloid Leukemia–derived Mutation in the G-CSF Receptor Gene

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Suppressor of Cytokine Signaling-3 Is Recruited to the Activated Granulocyte-Colony Stimulating Factor Receptor and Modulates its Signal Transduction

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The CXC-Chemokine Neutrophil-Activating Peptide-2 Induces Two Distinct Optima of Neutrophil Chemotaxis by Differential Interaction With Interleukin-8 Receptors CXCR-1 and CXCR-2

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Increased granulocyte colony-stimulating factor responsiveness but normal resting granulopoiesis in mice carrying a targeted granulocyte colony-stimulating factor receptor mutation derived from a patient with severe congenital neutropenia.

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Tyrosine-Dependent and -Independent Mechanisms of STAT3 Activation by the Human Granulocyte Colony-Stimulating Factor (G-CSF) Receptor Are Differentially Utilized Depending on G-CSF Concentration

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Perturbed Granulopoiesis in Mice With a Targeted Mutation in the Granulocyte Colony-Stimulating Factor Receptor Gene Associated With Severe Chronic Neutropenia

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The N-terminal Truncated Isoform of SOCS3 Translated from an Alternative Initiation AUG Codon under Stress Conditions Is Stable Due to the Lack of a Major Ubiquitination Site, Lys-6

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Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF–induced expansion of myeloid progenitor cells

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Regulation and Function of the Cytokine-Inducible SH-2 Domain Proteins, CIS and SOCS3, in Mammary Epithelial Cells

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Direct binding of Shc, Grb2, SHP-2 and p40 to the murine granulocyte colony-stimulating factor receptor

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Emergency granulopoiesis

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Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

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Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

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SOCS regulation of the JAK/STAT signalling pathway

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SOCS3, a Major Regulator of Infection and Inflammation

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Biology and significance of the JAK/STAT signalling pathways

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The role of IL-6 in host defence against infections: immunobiology and clinical implications

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Homeostatic Regulation of Blood Neutrophil Counts

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Leptin receptor action and mechanisms of leptin resistance

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SOCS, Inflammation, and Autoimmunity

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Nutritional investigation of non-obese patients with non-alcoholic fatty liver disease: The significance of dietary cholesterol

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Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-β1 production

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Androgen Receptor Influences on Body Defense System via Modulation of Innate and Adaptive Immune Systems

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Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-γ on STAT3 and Smads

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Deletion of the SOCS3 Gene in Liver Parenchymal Cells Promotes Hepatitis–Induced Hepatocarcinogenesis

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STAT3 Negatively Regulates Type I IFN-Mediated Antiviral Response

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SOCS Proteins in Immunity, Inflammatory Diseases, and Immune-Related Cancer

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Negative regulation of cytokine signaling and immune responses by SOCS proteins.

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The Structure of SOCS3 Reveals the Basis of the Extended SH2 Domain Function and Identifies an Unstructured Insertion That Regulates Stability

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Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor

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Applications of myeloid‐specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity

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Granulocyte colony-stimulating factor and its receptor in normal myeloid cell development, leukemia and related blood cell disorders

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SOCS: role in inflammation, allergy and homeostasis

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The biology and mechanism of action of Suppressor of Cytokine Signaling 3 (SOCS3)

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Highly Pathological Influenza A Virus Infection Is Associated with Augmented Expression of PD-1 by Functionally Compromised Virus-Specific CD8+T Cells

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The Comparative Roles of Suppressor of Cytokine Signaling-1 and -3 in the Inhibition and Desensitization of Cytokine Signaling

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GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS–induced lung cancer

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Selective Expansion of Foxp3-Positive Regulatory T Cells and Immunosuppression by Suppressors of Cytokine Signaling 3-Deficient Dendritic Cells

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STAT1 as a novel therapeutical target in pro-atherogenic signal integration of IFNγ, TLR4 and IL-6 in vascular disease

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The SOCS Box Domain of SOCS3: Structure and Interaction with the ElonginBC-Cullin5 Ubiquitin Ligase

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Negative Regulation of Cytokine and TLR Signalings by SOCS and Others

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Regulation of Cytokine Signaling by the SOCS and Spred Family Proteins

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Loss of SOCS3 Gene Expression Converts STAT3 Function from Anti-apoptotic to Pro-apoptotic

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Suppressor of cytokine signaling 3 controls lysosomal routing of G‐CSF receptor

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Regulation of emergency granulopoiesis during infection

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FoxO3a regulates hematopoietic homeostasis through a negative feedback pathway in conditions of stress or aging

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G-CSF receptor truncations found in SCN/AML relieve SOCS3-controlled inhibition of STAT5 but leave suppression of STAT3 intact

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Normal Hematopoiesis Is a Balancing Act of Self-Renewal and RegenerationPreprint

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The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo

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The transcription factors STAT5A/B regulate GM-CSF–mediated granulopoiesis

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Peptidoglycan and lipopolysaccharide activate PLCγ2, leading to enhanced cytokine production in macrophages and dendritic cells

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Ligand Independence of the T618I Mutation in the Colony-stimulating Factor 3 Receptor (CSF3R) Protein Results from Loss of O-Linked Glycosylation and Increased Receptor Dimerization

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Mutations of HNF-1β inhibit epithelial morphogenesis through dysregulation of SOCS-3

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Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation

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Roles of Stat3 and ERK in G‐CSF Signaling

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SOCS3 in immune regulation of inflammatory bowel disease and inflammatory bowel disease-related cancer

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RIG-I plays a critical role in negatively regulating granulocytic proliferation

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The expression of microRNA‐203 during human skin morphogenesis

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The role of granulocyte colony‑stimulating factor in breast cancer development: A review

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Molecular mechanisms involved in interleukin-4-induced human neutrophils: expression and regulation of suppressor of cytokine signaling

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Suppressor of cytokine signalling protein SOCS3 expression is increased at sites of acute and chronic inflammation

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The significance of differences in fatty acid metabolism between obese and non-obese patients with non-alcoholic fatty liver disease

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Deficiency of Socs3 leads to brain-targeted experimental autoimmune encephalomyelitis via enhanced neutrophil activation and ROS production

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Alcohol Suppresses the Granulopoietic Response to Pulmonary Streptococcus pneumoniae Infection with Enhancement of STAT3 Signaling

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Antigen Presentation by Dendritic Cells in Tumors Is Disrupted by Altered Metabolism that Involves Pyruvate Kinase M2 and Its Interaction with SOCS3

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Negative Regulation of Cytokine Signaling

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Germline STAT3 gain-of-function mutations in primary immunodeficiency: Impact on the cellular and clinical phenotype

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Critical and Independent Role for SOCS3 in Either Myeloid or T Cells in Resistance to Mycobacterium tuberculosis

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A review of granulocyte colony-stimulating factor receptor signaling and regulation with implications for cancer

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Prostaglandin E2 is a major soluble factor produced by stromal cells for preventing inflammatory cytokine production from dendritic cells

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Cloning of common carp SOCS-3 gene and its expression during embryogenesis, GH-transgene and viral infection

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Regulation of hematopoietic cell development and function by Stat3

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Identification of CCR2, flotillin, and gp49B genes as new G-CSF targets during neutrophilic differentiation

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Distinct activities of suppressor of cytokine signaling (SOCS) proteins and involvement of the SOCS box in controlling G-CSF signaling

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Influence of androgens on the innate immune system

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MiR-125a Is a critical modulator for neutrophil development

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Suppression of SOCS3 expression in the pancreatic β-cell leads to resistance to type 1 diabetes

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MCPIP-1 Restricts Inflammation via Promoting Apoptosis of Neutrophils

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Muscle-specific deletion of SOCS3 increases the early inflammatory response but does not affect regeneration after myotoxic injury

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Granulocyte colony-stimulating factor directly acts on mouse lymphoid-biased but not myeloid-biased hematopoietic stem cells

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Conditional overexpression of Stat3α in differentiating myeloid cells results in neutrophil expansion and induces a distinct, antiapoptotic and pro‐oncogenic gene expression pattern

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SOCS, SPRED, and NR4a: Negative regulators of cytokine signaling and transcription in immune tolerance

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Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice

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Tumor necrosis factor‐α augments lipopolysaccharide‐induced suppressor of cytokine signalling 3 (SOCS‐3) protein expression by preventing the degradation

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Tyrosine-phosphorylated SOCS3 Interacts with the Nck and Crk-L Adapter Proteins and Regulates Nck Activation

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Deletion of Stat3 enhances myeloid cell expansion and increases the severity of myeloproliferative neoplasms in Jak2V617F knock-in mice

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Suppressor of Cytokine Signaling 3 Promotes Bone Marrow Cells to Differentiate into CD8+ T Lymphocytes in Lung Tissue via Up-Regulating Notch1 Expression

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Murine models of vascular endothelial injury: Techniques and pathophysiology

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The Negative Regulation of JAK/STAT Signaling

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SOCS3 expression correlates with severity of inflammation in mouse hepatitis virus strain 3-induced acute liver failure and HBV-ACLF

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Expression of suppressor of cytokine signalling 3 ( SOCS 3) in human bladder epithelial cells infected with uropathogenic E scherichia coli

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Pharmacogenetics of Efficacy and Safety of HCV Treatment in HCV-HIV Coinfected Patients: Significant Associations with IL28B and SOCS3 Gene Variants

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Socs3b regulates the development and function of innate immune cells in zebrafish

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Ligation of CD200R by CD200 is not required for normal murine myelopoiesis

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Suppressor of cytokine signaling and accelerated atherosclerosis in kidney disease.

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Identification of SOCS3 and PTGS2 as new biomarkers for the diagnosis of gout by cross-species comprehensive analysis

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Diverse signaling mechanisms and heterogeneity of astrocyte reactivity in Alzheimer's disease

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Investigation of the interleukin (IL)‐4/IL‐4 receptor system in promyelocytic leukaemia PLB‐985 cells during differentiation toward neutrophil‐like phenotype: mechanism involved in IL‐4‐induced SOCS3 protein expression

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Transcriptional Regulation of Emergency Granulopoiesis in Leukemia

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“Suppressor of Cytokine Signalling” Molecules in Infection and Inflammation

Carow, B., & Martin, E. (2012) · InTech eBooks · doi:10.5772/25986 · Cited by 4 · see citing works

Cytokine Production by Neutrophils

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Role of SOCS proteins in inflammation and autoimmune diseases

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Deletion of suppressor of cytokine signaling 3 (SOCS3) in muscle stem cells does not alter muscle regeneration in mice after injury

Swiderski, K., Caldow, M. K., Naim, T., Trieu, J., Chee, A., Koopman, R., & Lynch, G. S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212880 · Cited by 3 · see citing works

Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes

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Detection of Endogenous SOCS1 and SOCS3 Proteins by Immunoprecipitation and Western Blot Analysis

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SOCS3 Is a Critical Physiological Negative Regulator of G-CSF Signaling and Emergency Granulopoiesis

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STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation

Lee, C.-K., Raz, R., Gimeno, R., Gertner, R., Wistinghausen, B., Takeshita, K., DePinho, R. A., & Levy, D. E. (2002) · Immunity · doi:10.1016/s1074-7613(02)00336-9 · Cited by 242 · see citing works

Suppressor of Cytokine Signaling-3 (SOCS3) Selectively Modulates Progenitor Cell Proliferation and Differentiation Induced by G-CSF and IL-6, and the Synergy between SCF and IL-6.

Roberts, A. W., Mielke, L. A., Wormald, S., Kiu, H., Croker, B. A., Hilton, D. J., Metcalf, D., & Alexander, W. S. (2006) · Blood · doi:10.1182/blood.v108.11.631.631 · Cited by 1 · see citing works

Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation

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Distinct activities of suppressor of cytokine signaling (SOCS) proteins and involvement of the SOCS box in controlling G-CSF signaling

van de Geijn, G. M., Gits, J., & Touw, I. P. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0104041 · Cited by 35 · see citing works