The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Immune Defence in Mice Lacking Type I and/or Type II Interferon Receptors
Open accessAbstract
Mice lacking the receptor for type I interferon (IFN-alpha beta, A129 mice), for type II interferon (IFN-gamma, G129 mice) or for both receptors (AG129 mice) have been generated by embryonic stem cell mediated gene targeting and inter-crossing A129 x G129, respectively. The role of the two IFN systems in controlling a range of infections has been studied using these mice. Type I IFN is shown to be responsible for the immune defence against most viral infections tested (Lymphocytic Choriomeningitis Virus, Semliki Forest Virus, Theiler's Virus, Vesicular Stomatitis Virus), type II IFN seems to be of little importance. In Vaccinia Virus and Theiler's Virus infection, however, both IFN systems were found to play a nonredundant role. IFN-gamma was critical for the defence against intracellular bacteria (Mycobacterium, Listeria) and parasites (Leishmania), whereas IFN-alpha beta was not. IFN-alpha beta is produced by virus-infected cells within hours and plays an important role in preventing virus spread early. Production of IFN-gamma on the other hand needs activation of the immune system and plays a major role later, i.e. mostly during the immune response. Data obtained with the mice described here show that both IFN systems seem to have evolved to complement each other in the host defence against a wide variety of infectious agents.
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Cited by
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The dual nature of type I and type II interferons
Lee, A. J., & Ashkar, A. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02061 · Cited by 690
Clinical implications of dysregulated cytokine production
Slifka, M. K., & Whitton, J. L. (2000) · Journal of Molecular Medicine · doi:10.1007/s001090000086 · Cited by 655
Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies
Patel, S. A., & Minn, A. J. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.007 · Cited by 573
Impairment of Mycobacterial But Not Viral Immunity by a Germline Human STAT1 Mutation
Dupuis, S., Dargemont, C., Fieschi, C., Thomassin, N., Rosenzweig, S., Harris, J., Holland, S. M., Schreiber, R. D., & Casanova, J.-L. (2001) · Science · doi:10.1126/science.1061154 · Cited by 517
Metadata
- Authors
- VAN DEN BROEK, M. F., MULLER, U., HUANG, S., ZINKERNAGEL, R. M., & AGUET, M.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 1995-12
- Volume
- 148
- Issue
- 1
- Pages
- 5-18
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2072823316
- Cited by
- 306
- References
- 52
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- green
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- VAN DEN BROEK, M. F., MULLER, U., HUANG, S., ZINKERNAGEL, R. M., & AGUET, M. (1995). Immune Defence in Mice Lacking Type I and/or Type II Interferon Receptors. Immunological Reviews. https://doi.org/10.1111/j.1600-065x.1995.tb00090.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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