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Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes
Abstract
Interferon-γ (IFN-γ) is a pleiotrophic cytokine with immunomodulatory effects on a variety of immune cells. Mice with a targeted disruption of the IFN-γ gene were generated. These mice developed normally and were healthy in the absence of pathogens. However, mice deficient in IFN-γ had impaired production of macrophage antimicrobial products and reduced expression of macrophage major histocompatibility complex class II antigens. IFN-γ-deficient mice were killed by a sublethal dose of the intracellular pathogen Mycobacterium bovis . Splenocytes exhibited uncontrolled proliferation in response to mitogen and alloantigen. After a mixed lymphocyte reaction, T cell cytolytic activity was enhanced against allogeneic target cells. Resting splenic natural killer cell activity was reduced in IFN-γ-deficient mice. Thus, IFN-γ is essential for the function of several cell types of the murine immune system.
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Citations
Cited by
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742
The M1 and M2 paradigm of macrophage activation: Time for reassessment
Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689
HOW CELLS RESPOND TO INTERFERONS
Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932
CELLULAR RESPONSES TO INTERFERON-γ
Boehm, U., Klamp, T., Groot, M., & Howard, J. C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.749 · Cited by 2,890
Metadata
- Authors
- Dalton, D. K., Pitts-Meek, S., Keshav, S., Figari, I. S., Bradley, A., & Stewart, T. A.
- Venue
- Science
- Published
- 1993-03-19
- Volume
- 259
- Issue
- 5102
- Pages
- 1739-1742
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2089262366
- Cited by
- 1,727
- References
- 0
- FWCI
- 27.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dalton, D. K., Pitts-Meek, S., Keshav, S., Figari, I. S., Bradley, A., & Stewart, T. A. (1993). Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes. Science. https://doi.org/10.1126/science.8456300
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