The DOI matches its Crossref record; 146 of the 147 references it cites were found in a registry or an index.
The metabolic life and times of a T‐cell
Open accessAbstract
Summary: The regulation of lymphocyte homeostasis is critical for the development and formation of productive immune responses. Cell numbers must be maintained to allow sufficient numbers of lymphocytes to combat foreign pathogens but prevent the accumulation of excess lymphocytes that may increase the risk of developing autoimmunity or neoplasia. Cell extrinsic growth factors are essential to maintain homeostasis and cell survival, and it has become increasingly apparent that a key mechanism of this control is through regulation of cell metabolism. The metabolic state of T cells can have profound influences on cell growth and survival and even differentiation. In particular, resting T cells utilize an energy efficient oxidative metabolism but shift to a highly glycolytic metabolism when stimulated to grow and proliferate by pathogen encounter. After antigen clearance, T cells must return to a more quiescent oxidative metabolism to support T‐cell memory. This review highlights how these metabolic changes may be intricately involved with both T‐cell growth and death in the control of homeostasis and immunity.
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“there has been an increasing understanding of the central importance of metabolism in regulating T cell function [5, 106, 107].”
From Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function (2013) · cites this paper as [107]
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Metadata
- Authors
- Michalek, R. D., & Rathmell, J. C.
- Affiliations
- Duke Medical Center (US)
- Corresponding author
- Rathmell, Jeffrey C.
- ORCID
- Rathmell, Jeffrey C.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2010-06-15
- Volume
- 236
- Issue
- 1
- Pages
- 190-202
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- PMC
- PMC2983473
- OpenAlex
- W1672445637
- Cited by
- 186
- References
- 147
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 10 · 2023: 8 · 2022: 17 · 2021: 10 · 2020: 13 · 2019: 11 · 2018: 22 · 2017: 15 · 2016: 11 · 2015: 3 · 2014: 15 · 2013: 14 · 2012: 24
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA123350)
- National Institute of Allergy and Infectious Diseases (R01AI063345)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- T cell metabolism, lymphocyte homeostasis, oxidative phosphorylation, glycolysis, T cell quiescence, T cell proliferation, T cell differentiation, T cell memory, T cell death, cell survival, cell growth, autoimmunity, cancer
- MeSH terms
- Animals, Cell Survival, Homeostasis, Humans, Immunity, T-Lymphocytes, Time Factors, Apoptosis, Models, Immunological, Lymphocyte Count
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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