Clinical chemistry and hematology values in a Caribbean population of African green monkeys
Abstract
Background Hematology and clinical chemistry (HCC) reference values are critical in veterinary practice and in vivo pre‐clinical research, enabling detection of health abnormalities, response to therapeutic intervention or adverse toxicological effects, as well as monitoring of clinical management. Methods In this report, reference ranges for 46 HCC parameters were characterized in 331 wild‐caught and colony‐bred African green monkeys. Effects of sex, weight and duration of captivity were determined by one‐way analysis of variance. Results Significant sex differences were observed for several HCC parameters. Significant differences were also observed for select HCC variables between newly caught animals and those held in captivity for 1–12 months or longer. Conclusions Comparison of this data with other non‐human primate species and humans highlights similarities and disparities between species. Potential causes of interpopulation variability and relevance to the use of the African green monkey as a non‐human primate model are discussed.
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Statistical comparisons were considered significant if p < 0.01 because of the small sample size (n = 3/group) and daily variations in cell numbers and serum chemistries.
“Due to the small sample size (n = 3/group) and daily variations in cell numbers and serum chemistries, statistical comparisons were considered to be significant if p < 0.01.31,37,38”
From AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease (2018) · cites this paper as [38]
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AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease
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Rosenberg, J. B., Chen, A., De, B. P., Dyke, J. P., Ballon, D. J., Monette, S., Ricart Arbona, R. J., Kaminsky, S. M., Crystal, R. G., & Sondhi, D. (2021) · Human Gene Therapy · doi:10.1089/hum.2020.269 · Cited by 41 · see citing works
- Authors
- Liddie, S., Goody, R. J., Valles, R., & Lawrence, M. S.
- Corresponding author
- Lawrence, Matthew S.
- Venue
- Journal of Medical Primatology
- Publisher
- Wiley
- Published
- 2010-11-03
- Volume
- 39
- Issue
- 6
- Pages
- 389-398
- ISSN
- 0047-2565 (ISSN-L)
- 1600-0684
- OpenAlex
- W1899674496
- Cited by
- 34
- References
- 22
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 4 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 4 · 2015: 4 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medical Primatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Health Sciences › Veterinary › Small Animals › Veterinary Medicine and Surgery
- Keywords
- vervet monkey, Chlorocebus aethiops, reference values, hematology, clinical chemistry, nonhuman primate model, sex differences, interpopulation variability, Caribbean population
- MeSH terms
- Albumins, Alkaline Phosphatase, Animals, Aspartate Aminotransferases, Bilirubin, Blood Glucose, Body Weight, Chlorocebus aethiops, Cholesterol, Creatine Kinase, Creatinine, Female, Globulins, Male, Minerals, Sex Characteristics, Triglycerides, Caribbean Region
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