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Cited by 54Oral microbiology and periodontitis researchPeriodontal Regeneration and TreatmentsDental Research and COVID-19

The effect of initial treatment of periodontitis on systemic markers of inflammation and cardiovascular risk: a randomized controlled trial

Taylor, Barbara, Tofler, Geoffrey, Morel‐Kopp, Marie‐Christine, Carey, Helen, Carter, Torren, Elliott, Margaret, Dailey, Colette, Villata, Luke +3 more·2010·European Journal Of Oral Sciences
DOI 10.1111/j.1600-0722.2010.00748.x
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Abstract

Taylor B, Tofler G, Morel‐Kopp M‐C, Carey H, Carter T, Elliott M, Dailey C, Villata L, Ward C, Woodward M, Schenck K. The effect of initial treatment of periodontitis on systemic markers of inflammation and cardiovascular risk: a randomized controlled trial. Eur J Oral Sci 2010; 118: 350–356. © 2010 The Authors. Journal compilation © 2010 Eur J Oral Sci Observational studies indicate that chronic periodontal disease is associated with adverse cardiovascular outcomes. The aim of this study was to determine whether initial periodontal treatment has a beneficial effect on systemic markers of inflammation and cardiovascular risk. One hundred and thirty‐six adults with chronic periodontitis were allocated to either intervention or control groups in a 3‐month randomized controlled intervention study. The intervention group received initial periodontal treatment, whereas the control group did not receive that treatment until after the study. Blood levels of cardiovascular risk factors, and of hematological, inflammatory, and metabolic markers, were measured at the beginning and the end of the study, and differences were calculated. Fibrinogen level was the primary outcome measure. Data for 61 persons in the intervention group and for 64 persons in the control group were available for statistical analysis. Compared with the control group, the intervention group showed a non‐significant trend for a lower fibrinogen level. Significant increases in hemoglobin and hematocrit were seen after treatment, showing that initial periodontal treatment, a relatively simple and cost‐effective intervention, has systemic effects.

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  • Acute increase in endothelial-activation markers including E-selectin, vWF, haemoglobin and haematocrit, D-dimer levels, and neutrophil counts was reported 24 h following periodontal therapy in several publications.

    “Acute increase in endothelial-activation markers including E-selectin, vWF, haemoglobin and haematocrit, D-dimer levels, and neutrophils counts was also reported 24 h following periodontal therapy in several publications.22,44,58”

    From Periodontitis is associated with hypertension: a systematic review and meta-analysis (2020) · cites this paper as [44]

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Authors
Taylor, B., Tofler, G., Morel‐Kopp, M., Carey, H., Carter, T., Elliott, M., Dailey, C., Villata, L., Ward, C., Woodward, M., & Schenck, K.
Affiliations
  • University of Oslo (NO)
  • Royal North Shore Hospital (AU)
  • The University of Sydney (AU)
  • Sydney Dental Hospital (AU)
Corresponding author
Schenck, Karl
ORCID
Venue
European Journal Of Oral Sciences
Publisher
Wiley
Published
2010-07-12
Volume
118
Issue
4
Pages
350-356
ISSN
  • 0029-845X (ISSN-L)
  • 0909-8836
  • 1600-0722
DOI
10.1111/j.1600-0722.2010.00748.x
OpenAlex
W1533817079
Cited by
54
References
27
Citations by year
2025: 3 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 9 · 2012: 2
FWCI
5.19
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • European Journal Of Oral Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
  • Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
Keywords
chronic periodontitis, initial periodontal treatment, systemic inflammation, cardiovascular risk, fibrinogen, hemoglobin, hematocrit, cardiovascular risk factors, inflammatory markers, metabolic biomarkers
MeSH terms
Adult, C-Reactive Protein, Cardiovascular Diseases, Cholesterol, Female, Fibrinogen, Follow-Up Studies, Gingival Hemorrhage, Gingival Recession, Hematocrit, Hemoglobins, Humans, Cholesterol, HDL, Male, Middle Aged, Periodontal Pocket, Tissue Plasminogen Activator, Prospective Studies, Risk Factors, von Willebrand Factor, Biomarkers, Treatment Outcome, Plasminogen Activator Inhibitor 1, Periodontal Attachment Loss, Lymphocyte Count, Inflammation Mediators, Chronic Periodontitis

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