The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Two years oral use of chlorhexidine in man: I. General design and clinical effects
Abstract
The general objectives of this study were to examine the long term effects of daily chlorhexidine application on the development of dental plaque, calculus and periodontal pathology and to monitor changes in oral microbiology and any systemic or local side effects following prolonged use of chlorhexidine over a period of two years. An experimental group of 61 medical and dental students used 10 ml. of 0.2 per cent aqueous solution of chlorhexidine gluconate daily in addition to tooth brushing and interdental cleansing. A control group of 59 students used a placebo solution in addtion to tooth brushing and interdental cleansing. Assessment of selected oral and systemic parameters took place at regular intervals throughout the experiment. The results show that, when compared to the placebo solution, chlorhexidine treatment reduced plaque and gingivitis, but tended to stain teeth. Stains were readily removed by a conventional dental prophylaxis procedure. The chlorhexidine group tended to exhibit a greater amount of supragingival calculus. There were no other local side effects relative to the structure and function of the oral mucosa, tongue, salivary glands and pharyngeal complex, following the prolonged use of chlorhexidine.
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Citations
Cites
Periodontal Disease in Pregnancy II. Correlation Between Oral Hygiene and Periodontal Condition
Silness, J., & Löe, H. (1964) · Acta Odontologica Scandinavica · doi:10.3109/00016356408993968 · Cited by 7,932
Periodontal Disease in Pregnancy I. Prevalence and Severity
Löe, H., & Silness, J. (1963) · Acta Odontologica Scandinavica · doi:10.3109/00016356309011240 · Cited by 7,203
Löe, H., & Rindom Schiøtt, C. (1970) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1970.tb00696.x · Cited by 857
Errors in the clinical assessment of periodontal destruction
Glavind, L., & Löe, H. (1967) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1967.tb01887.x · Cited by 394
Self-citationTwo years oral use of chlorhexidine in man: III. Changes in sensitivity of the salivary flora
RindomSchiöstt, C., Briner, W. W., Kirkland, J. J., & Löue, H. (1976) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1976.tb00063.x · Cited by 214
Self-citationIn Vivo Calculus Assessment: Part I A Method and Its Examiner Reproducibility
Volpe, A. R., Manhold, J. H., & Hazen, S. P. (1965) · Journal of Periodontology · doi:10.1902/jop.1965.36.4.292 · Cited by 121
Two year oral use of chlorhexidine in man: II. The effect on the salivary bacterial flora
RindomSchiöstt, C., Briner, W. W., & Löue, H. (1976) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1976.tb00062.x · Cited by 97
Self-citationThe effect of mouthrinses and topical application of chlorhexidine on calculus formation in man
Loe, H., Mandell, M., Derry, A., & SchiøTt, C. R. (1971) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1971.tb00623.x · Cited by 49
Two year oral use of chlorhexidine in man: IV. Effect on various medical parameters
Rindom‐Schiöutt, C., Löue, H., & Briner, W. W. (1976) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1976.tb00064.x · Cited by 48
Self-citationTwo years oral use of chlorhexidine in man: V. Effects on stratum corneum of oral mucosa
Mackenzie, I. C., Nuki, K., Löue, H., & SchiøTt, C. R. (1976) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1976.tb00065.x · Cited by 46
Self-citation
Cited by
Subgingival microflora and periodontal disease
Slots, J. (1979) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.1979.tb01935.x · Cited by 800
Nonsurgical and surgical treatment of periodontitis: how many options for one disease?
Graziani, F., Karapetsa, D., Alonso, B., & Herrera, D. (2017) · Periodontology 2000 · doi:10.1111/prd.12201 · Cited by 566
Nonsurgical periodontal therapy
Drisko, C. H. (2001) · Periodontology 2000 · doi:10.1034/j.1600-0757.2001.22250106.x · Cited by 356
Van Strydonck, D. A. C., Slot, D. E., Van der Velden, U., & Van der Weijden, F. (2012) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.2012.01883.x · Cited by 353
White, D. J. (1997) · European Journal of Oral Sciences · doi:10.1111/j.1600-0722.1997.tb00238.x · Cited by 325
Metadata
- Authors
- Löue, H., Rindom Schiöutt, C., Glavind, L., & Karring, T.
- Venue
- Journal of Periodontal Research
- Publisher
- Wiley
- Published
- 1976-06
- Volume
- 11
- Issue
- 3
- Pages
- 135-144
- ISSN
- 0022-3484 (ISSN-L)
- 1600-0765
- OpenAlex
- W2018347400
- Cited by
- 276
- References
- 11
- FWCI
- 17.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Two years oral use of chlorhexidine in man: I. General design and clinical effects. https://app.cochat.ai/papers/10.1111/j.1600-0765.1976.tb00061.x
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- Löue, H., Rindom Schiöutt, C., Glavind, L., & Karring, T. (1976). Two years oral use of chlorhexidine in man: I. General design and clinical effects. Journal of Periodontal Research. https://doi.org/10.1111/j.1600-0765.1976.tb00061.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
