The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Han/Wistar Rats are Exceptionally Resistant to TCDD. I
Abstract
Abstract:Adult male Han/Wistar rats were administered 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) intraperitoneally at doses ranging from 125 to 1400 μg/kg and monitored for 39 to 48 days. Two rats succumbed in the course of the experiment: one in the group receiving 625 and one dosed 1000 μg/kg. Body weights of the animals decreased by 20 to 30% during the first 10 to 14 days and became stable thereafter. Feed consumption decreased to 1/3‐1/2 of control levels by Day 4 (calculated per metabolic body mass) and returned gradually to starting values by about 4 weeks after dosing. Water intake displayed a triphasic pattern: at first it was slightly increased (Days 1 to 3), then reduced (on Days 4 to 12) and finally increased again throughout the remainder of the test period. The absolute and/or relative weights of thymus, testicles, ventral prostate and interscapular brown fat were significantly decreased at termination. These results indicate that the LD50‐value for TCDD in the male, adult Han/Wistar rat is substantially above 1400 μg/kg, and that suppression of appetite is the principal phenomenon responsible for TCDD‐induced body weight reduction.
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“Like mice, naturally occurring polymorphisms at the rat Ahr locus have provided models that have shed light on AHR signal transduction (Pohjanvirta et al., 1987; Pohjanvirta et al., 1999).”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Pohjanvirta et al., 1987
Citations
Cites
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The comparative toxicity of chlorinated dibenzo-p-dioxins in mice and guinea pigs
McConnell, E. E., Moore, J. A., Haseman, J. K., & Harris, M. W. (1978) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(78)90195-3 · Cited by 381
Dietary Obesity in Rats: Body Weight and Body Fat Accretion in Seven Strains of Rats
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Gasiewicz, T. A., Geiger, L. E., Rucci, G., et al. (1983) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)08040-7 · Cited by 185
Characterization of the wasting syndrome in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin
Seefeld, M. D., Corbett, S. W., Keesey, R. E., & Peterson, R. E. (1984) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(84)90337-5 · Cited by 167
Androgenic deficiency in male rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin
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Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Golden Syrian hamster
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TOXICOPATHOLOGY CHARACTERISTICS OF THE HALOGENATED AROMATICS
McConnell, E. E., & Moore, J. A. (1979) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1979.tb13140.x · Cited by 120
Dose-related effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL6J and DBA2J mice
Chapman, D. E., & Schiller, C. M. (1985) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(85)90314-x · Cited by 115
2,3,7,8-Tetrachlorodibenzo-p-dioxin: Acute oral toxicity in hamsters
Henck, J. M., New, M. A., Kociba, R. J., & Rao, K. S. (1981) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(81)90212-x · Cited by 105
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Acute myelotoxic responses in mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
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Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin upon Hemostasis and Hematologic Function in the Rat
Weissberg, J. B., & Zinkl, J. G. (1973) · Environmental Health Perspectives · doi:10.1289/ehp.7305119 · Cited by 38
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Self-citationMetabolic studies with TCDD (dioxin) treated rats
Courtney, K. D., Putnam, J., & Andrews, J. E. (1978) · Archives of Environmental Contamination and Toxicology · doi:10.1007/bf02332066 · Cited by 25
Separation of wasting syndrome and lethality caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin
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Self-citation
Research works printed but not linked: 2
- 10.1111/j.1749-6632.1979.tb56597.x · DOI
- Seefeld M. D.&R. E.Peterson:The starvation‐like syndrome and 2 3 7 8‐tetrachlorodibenzo‐p‐dioxin: new ideas on the mode of action at the whole animal level.Proc. Conf. Environ. Toxicol. (13th) California Univ. Dayton OH.1983.
Cited by
Pohjanvirta, R., Juvonen, R., Kärenlampi, S., Raunio, H., & Tuomisto, J. (1988) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(88)90235-9 · Cited by 85
Self-citationRodent Genetic Models of Ah Receptor Signaling
Wilson, R. H., & Bradfield, C. A. (2021) · Drug Metabolism Reviews · doi:10.1080/03602532.2021.1955916 · Cited by 16
“Like mice, naturally occurring polymorphisms at the rat Ahr locus have provided models that have shed light on AHR signal transduction (Pohjanvirta et al. 1987, 1999).”
Background
Metadata
- Authors
- Pohjanvirta, R., Tuomisto, J., Vartiainen, T., & Rozman, K.
- Venue
- Pharmacology & Toxicology
- Publisher
- Wiley
- Published
- 1987-02
- Volume
- 60
- Issue
- 2
- Pages
- 145-150
- ISSN
- 0901-9928
- Cited by
- 64
- References
- 19
- Language
- en
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