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Toxicology of chlorinated dibenzo-p-dioxins.
Open accessAbstract
Severe toxicological responses have been associated with certain chlorodibenzodioxins. One of these responses is chloracne, a folliculosis first associated with skin contamination by chlorohydrocarbons in 1899 (1)). Serious outbreaks of chloracne-like lesions associated with runaway reactions in the production of 2,4,5-trichlorophenol occurred in Germany in the early 1950's (2). 2,4,5Trichlorophenol itself does not cause acne (3), but the contaminants which may be formed in the uncontrolled production of 2,4,5-trichlorophenol are extremely potent acnegens (2). 2,3,7,8-Tetrachlorodibenzo-pdioxin and triand tetrachlorodibenzofuran were isolated from the contaminants formed in 2,4,5-trichlorophenol production and were demonstrated to be strongly positive acnegens when applied to rabbit ears (3). By using the rabbit ear test, the acnegenic potency of 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) was confirmed in 1962 (4). In addition, 2,3,7,8-TCDD is extremely toxic in the chick embryo assay (5) and is highly embryotoxic in rats (6). Another chlorodibenzodioxin, hexachlorodibenzo-pdioxin (HCDD), is known to be positive for the chick edema factor, a condition characterized by hydropericardium, ascites, and anasarca (5, 7).
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Cited by
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Hahn, M. E. (2002) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00070-4 · Cited by 642
Pohjanvirta, R., Wong, J. M. Y., Li, W., Harper, P. A., Tuomisto, J., & Okey, A. B. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.1.86 · Cited by 184
Iron Deficiency Prevents Liver Toxicity of 2,3,7,8-Tetrachlorodibenzo- p -Dioxin
Sweeny, G. D., Jones, K. G., Cole, F. M., Basford, D., & Krestynski, F. (1979) · Science · doi:10.1126/science.432648 · Cited by 112
2,3,7,8-Tetrachlorodibenzo-p-dioxin: Acute oral toxicity in hamsters
Henck, J. M., New, M. A., Kociba, R. J., & Rao, K. S. (1981) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(81)90212-x · Cited by 105
Metadata
- Authors
- Schwetz, B. A., Norris, J. M., Sparschu, G. L., Rowe, U. K., Gehring, P. J., Emerson, J. L., & Gerbig, C. G.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 1973-09
- Volume
- 5
- Pages
- 87-99
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2008143869
- Cited by
- 492
- References
- 0
- FWCI
- 17.01
- Type
- journal article
- Language
- en
- Open access
- gold
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- Schwetz, B. A., Norris, J. M., Sparschu, G. L., Rowe, U. K., Gehring, P. J., Emerson, J. L., & Gerbig, C. G. (1973). Toxicology of chlorinated dibenzo-p-dioxins. Environmental Health Perspectives. https://doi.org/10.1289/ehp.730587
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