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Cited by 116Circadian rhythm and melatoninDiet, Metabolism, and DiseaseAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Melatonin improves metabolic syndrome induced by high fructose intake in rats

Kitagawa, Akira, Ohta, Yoshiji, Ohashi, Koji·2012·Journal of Pineal Research
DOI 10.1111/j.1600-079x.2011.00955.x
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Abstract

Abstract: In this study, we examined whether melatonin improves metabolic syndrome induced by high fructose intake in male Wistar rats. Feeding of a diet containing 60% fructose (HFD) for 4 or 6 wk caused increased serum insulin, triglyceride, total cholesterol, free fatty acids, uric acid, leptin, and lipid peroxide concentrations as well as hepatic triglyceride and cholesterol concentrations, and relative intra‐abdominal fat and liver weights. The 4‐ or 6‐wk HFD feeding reduced serum high‐density lipoprotein cholesterol and adiponectin concentrations. The 6‐wk HFD feeding increased serum tumor necrosis factor‐α concentration and hepatic lipid peroxide concentration and lowered hepatic reduced glutathione concentration. Daily intraperitoneal administration of melatonin (1 or 10 mg/kg body weight), starting at 4‐wk HFD feeding, attenuated these changes at 6‐wk HFD feeding more effectively at its higher dose than at its lower dose. In an oral glucose tolerance test, rats with 4‐ or 6‐wk HFD feeding showed higher serum insulin response curve and normal serum glucose response curve when compared with the corresponding animals that received the control diet. The 4‐ or 6‐wk HFD feeding caused insulin resistance, judging from the scores of HOMR‐IR and QUICKI, which are indices of insulin resistance. The daily administered melatonin (1 or 10 mg/kg body weight) ameliorated the higher serum insulin response curve in the oral glucose tolerance test and insulin resistance at 6‐wk HFD feeding more effectively at its higher dose than at its lower dose. These results indicate that melatonin improves metabolic syndrome induced by high fructose intake in rats.

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Crossref · 10.1111/j.1600-079x.2011.00955.x

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Metadata

Authors
Kitagawa, A., Ohta, Y., & Ohashi, K.
Affiliations
  • Shigakkan University (JP)
  • Fujita Health University (JP)
Corresponding author
Ohta, Yoshiji
ORCID
Kitagawa, Akira
Venue
Journal of Pineal Research
Publisher
Wiley
Published
2012-05
Volume
52
Issue
4
Pages
403-413
ISSN
  • 0742-3098 (ISSN-L)
  • 1600-079X
DOI
10.1111/j.1600-079x.2011.00955.x
OpenAlex
W2101370818
Cited by
116
References
58
Citations by year
2025: 2 · 2024: 7 · 2023: 5 · 2022: 4 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 9 · 2017: 18 · 2016: 6 · 2015: 6 · 2014: 18 · 2013: 11 · 2012: 5
FWCI
5.02
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 358 d)
Locations
  • Journal of Pineal Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
melatonin, metabolic syndrome, high-fructose diet, insulin resistance, glucose tolerance, lipid metabolism, adiponectin, leptin, TNF-α, oxidative stress, liver cholesterol, intra-abdominal fat
MeSH terms
Analysis of Variance, Animals, Antioxidants, Blood Glucose, Body Weight, Cholesterol, Diet, Fructose, Glucose Tolerance Test, Insulin, Insulin Resistance, Lipid Peroxides, Lipids, Liver, Male, Melatonin, Uric Acid, Rats, Wistar, Oxidative Stress, Metabolic Syndrome, Rats, Adipokines

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