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Melatonin improves metabolic syndrome induced by high fructose intake in rats
Abstract
Abstract: In this study, we examined whether melatonin improves metabolic syndrome induced by high fructose intake in male Wistar rats. Feeding of a diet containing 60% fructose (HFD) for 4 or 6 wk caused increased serum insulin, triglyceride, total cholesterol, free fatty acids, uric acid, leptin, and lipid peroxide concentrations as well as hepatic triglyceride and cholesterol concentrations, and relative intra‐abdominal fat and liver weights. The 4‐ or 6‐wk HFD feeding reduced serum high‐density lipoprotein cholesterol and adiponectin concentrations. The 6‐wk HFD feeding increased serum tumor necrosis factor‐α concentration and hepatic lipid peroxide concentration and lowered hepatic reduced glutathione concentration. Daily intraperitoneal administration of melatonin (1 or 10 mg/kg body weight), starting at 4‐wk HFD feeding, attenuated these changes at 6‐wk HFD feeding more effectively at its higher dose than at its lower dose. In an oral glucose tolerance test, rats with 4‐ or 6‐wk HFD feeding showed higher serum insulin response curve and normal serum glucose response curve when compared with the corresponding animals that received the control diet. The 4‐ or 6‐wk HFD feeding caused insulin resistance, judging from the scores of HOMR‐IR and QUICKI, which are indices of insulin resistance. The daily administered melatonin (1 or 10 mg/kg body weight) ameliorated the higher serum insulin response curve in the oral glucose tolerance test and insulin resistance at 6‐wk HFD feeding more effectively at its higher dose than at its lower dose. These results indicate that melatonin improves metabolic syndrome induced by high fructose intake in rats.
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“Melatonin administration decreases the circulating leptin levels in most animal models, 29,30 however, the results are inconsistent in human studies. 19,31”
From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [29]
In the citing paper
“Different animal models and clinical studies approved the melatonin's effect on the treatment of circulating adiponectin. 19,29,30”
From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [29]
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Cites
1 retracted
El‐Bassossy, H. M., El‐Moselhy, M. A., & Mahmoud, M. F. (2011) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-011-0669-z · Cited by 41
RetractedMatthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
Ohkawa, H., Ohishi, N., & Yagi, K. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90738-3 · Cited by 29,746
Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent
Sedlak, J., & Lindsay, R. H. (1968) · Analytical Biochemistry · doi:10.1016/0003-2697(68)90092-4 · Cited by 8,092
Katz, A., Nambi, S. S., Mather, K., Baron, A. D., Follmann, D. A., Sullivan, G., & Quon, M. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6661 · Cited by 3,931
A simple fluorometric assay for lipoperoxide in blood plasma
Yagi, K. (1976) · Biochemical Medicine · doi:10.1016/0006-2944(76)90049-1 · Cited by 2,116
Metabolic syndrome: definitions and controversies
Kassi, E., Pervanidou, P., Kaltsas, G., & Chrousos, G. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-48 · Cited by 1,565
Melatonin as a natural ally against oxidative stress: a physicochemical examination
Galano, A., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00916.x · Cited by 1,167
A causal role for uric acid in fructose-induced metabolic syndrome
Nakagawa, T., Hu, H., Zharikov, S. I., Tuttle, K. R., Short, R., Glushakova, O. Y., Ouyang, X., Feig, D. I., Block, E. R., Herrera-Acosta, J., et al. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00140.2005 · Cited by 1,111
Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome
Maury, E., & Brichard, S. M. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.07.031 · Cited by 1,026
Oxidative stress and metabolic syndrome
Roberts, C. K., & Sindhu, K. K. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.02.026 · Cited by 883
A Review of the Multiple Actions of Melatonin on the Immune System
Carrillo‐Vico, A., Guerrero, J. M., Lardone, P. J., & Reiter, R. J. (2005) · Endocrine · doi:10.1385/endo:27:2:189 · Cited by 677
Melatonin: A Multitasking Molecule
Reiter, R. J., Tan, D. X., & Fuentes‐Broto, L. (2010) · Progress in brain research · doi:10.1016/s0079-6123(08)81008-4 · Cited by 642
Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-α
Ruan, H., & Lodish, H. F. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00052-2 · Cited by 541
Dekker, M. J., Su, Q., Baker, C., Rutledge, A. C., & Adeli, K. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00283.2010 · Cited by 432
Study of a new cholesterol reagent
Zlatkis, A., & Zak, B. (1969) · Analytical Biochemistry · doi:10.1016/0003-2697(69)90017-7 · Cited by 404
Tran, L. T., Yuen, V. G., & McNeill, J. H. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0184-4 · Cited by 374
Tan, D. ‐., Manchester, L. C., Fuentes‐Broto, L., Paredes, S. D., & Reiter, R. J. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00756.x · Cited by 353
Perez-Pozo, S. E., Schold, J. D., Nakagawa, T., Sánchez‐Lozada, L. G., Johnson, R. J., & Lillo, J. L. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.259 · Cited by 344
Melatonin: A Pleiotropic Molecule Regulating Inflammation
Radogna, F., Diederich, M., & Ghibelli, L. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.07.041 · Cited by 342
Teff, K. L., Grudziak, J., Townsend, R. R., Dunn, T. N., Grant, R. W., Adams, S. H., Keim, N. L., Cummings, B. P., Stanhope, K. L., & Havel, P. J. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2192 · Cited by 301
Koziróg, M., Poliwczak, A. R., Duchnowicz, P., Koter-Michalak, M., Sikora, J., & Broncel, M. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00835.x · Cited by 299
Melatonin Reduces Body Weight Gain in Sprague Dawley Rats with Diet-Induced Obesity
Prunet‐Marcassus, B., Desbazeille, M., Bros, A., Louche, K., Delagrange, P., Renard, P., Casteilla, L., & Pénicaud, L. (2003) · Endocrinology · doi:10.1210/en.2003-0693 · Cited by 281
Stanhope, K. L., & Havel, P. J. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.25825d · Cited by 238
Impairment of hepatic Stat-3 activation and reduction of PPARα activity in fructose-fed rats
Roglans, N., Vilà, L., Farré, M., Alegret, M., Sánchez, R. M., Vázquez‐Carrera, M., & Laguna, J. C. (2007) · Hepatology · doi:10.1002/hep.21499 · Cited by 226
The Determination of Triglycerides in Plasma and Tissues
Sardesai, V. M., & Manning, J. A. (1968) · Clinical Chemistry · doi:10.1093/clinchem/14.2.156 · Cited by 209
Dietary fructose and the metabolic syndrome
Miller, A., & Adeli, K. (2008) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3282f3f4c4 · Cited by 208
Melatonin as a potential antihypertensive treatment
Šimko, F., & Paulis, L. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00436.x · Cited by 207
Rats Fed Fructose-Enriched Diets Have Characteristics of Nonalcoholic Hepatic Steatosis
Kawasaki, T., Igarashi, K., Koeda, T., Sugimoto, K., Nakagawa, K., Hayashi, S., Yamaji, R., Inui, H., Fukusato, T., & Yamanouchi, T. (2009) · Journal of Nutrition · doi:10.3945/jn.109.105858 · Cited by 206
Functional Expression of MT2 (Mel1b) Melatonin Receptors in Human PAZ6 Adipocytes
Brydon, L., Petit, L., Delagrange, P., Strosberg, A. D., & Jockers, R. (2001) · Endocrinology · doi:10.1210/endo.142.10.8423 · Cited by 190
Silbernagel, G., Machann, J., Unmuth, S., Schick, F., Stefan, N., Häring, H. U., & Fritsche, A. (2011) · British Journal Of Nutrition · doi:10.1017/s000711451000574x · Cited by 173
Central Adiposity, Systemic Inflammation, and the Metabolic Syndrome
Elks, C. M., & Francis, J. (2010) · Current Hypertension Reports · doi:10.1007/s11906-010-0096-4 · Cited by 170
Melatonin ameliorates nonalcoholic fatty liver induced by high‐fat diet in rats
Pan, M., Song, Y., Xu, J., & Gan, H. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00346.x · Cited by 169
Beneficial effects of melatonin on obesity and lipid profile in young Zucker diabetic fatty rats
Agil, A., Navarro‐Alarcón, M., Ruiz, R., Abuhamdah, S. M. A., El‐Mir, M., & Vázquez, G. F. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00830.x · Cited by 168
Ríos-Lugo, M. J., Cano, P., Jiménez‐Ortega, V., Fernández‐Mateos, P., Scacchi, P. A., Cardinali, D. P., & Esquifino, A. I. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00798.x · Cited by 168
Reaction mechanism of melatonin oxidation by reactive oxygen species in vitro
Bonnefont‐Rousselot, D., Collin, F., Jore, D., & Gardès-Albert, M. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00847.x · Cited by 148
Role of melatonin in metabolic regulation
Korkmaz, A., Topal, T., Tan, D., & Reiter, R. J. (2009) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-009-9117-5 · Cited by 145
Melatonin enhances leptin expression by rat adipocytes in the presence of insulin
Alonso‐Vale, M. I. C., Andreotti, S., Peres, S. B., Anhê, G. F., Borges‐Silva, C. N., Cipolla‐Neto, J., & Lima, F. B. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00478.2004 · Cited by 135
Swarbrick, M. M., Stanhope, K. L., Elliott, S. S., Graham, J. L., Krauss, R. M., Christiansen, M. P., Griffen, S. C., Keim, N. L., & Havel, P. J. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508968252 · Cited by 132
Hu, Q., Wang, C., Li, J., Zhang, D., & Kong, L. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90767.2008 · Cited by 128
Stanhope, K. L., & Havel, P. J. (2009) · Journal of Nutrition · doi:10.3945/jn.109.106641 · Cited by 125
She, M., Deng, X., Guo, Z., Laudon, M., Hu, Z., Liao, D., Hu, X., Luo, Y., Shen, Q., & Su, Z. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.01.005 · Cited by 118
Sharabi, Y., Oron‐Herman, M., Kamari, Y., Avni, I., Peleg, E., Shabtay, Z., Grossman, E., & Shamiss, A. (2007) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2006.08.002 · Cited by 89
Fructose-rich diet-induced abdominal adipose tissue endocrine dysfunction in normal male rats
Alzamendi, A., Giovambattista, A., Raschia, M. A., Madrid, V., Gaillard, R. C., Rebolledo, O. R., Gagliardino, J. J., & Spinedi, E. (2009) · Endocrine · doi:10.1007/s12020-008-9143-1 · Cited by 88
Uric Acid as a Factor in the Metabolic Syndrome
Borges, R. L., Ribeiro, A. B., Zanella, M. T., & Batista, M. C. (2010) · Current Hypertension Reports · doi:10.1007/s11906-010-0098-2 · Cited by 87
The Effect of High-Fructose Corn Syrup Consumption on Triglycerides and Uric Acid
Angelopoulos, T. J., Lowndes, J., Zukley, L. M., Melanson, K. J., Nguyen, V., Huffman, A., & Rippe, J. M. (2009) · Journal of Nutrition · doi:10.3945/jn.108.098194 · Cited by 81
Effect of melatonin on the maintenance of cholesterol homeostasis in the rat
Chan, T. Y., & Tang, P. L. (1995) · Endocrine Research · doi:10.1080/07435809509030483 · Cited by 80
Melatonin–insulin interactions in patients with metabolic syndrome
Robeva, R. N., Кirilov, G., Tomova, A., & Kumanov, P. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00527.x · Cited by 76
Effects of pinealectomy and exogenous melatonin on serum leptin levels in male rat
Canpolat, S., Sandal, S., Yılmaz, B., Yaşar, A., Kutlu, S., Baydaş, G., & Keleştimur, H. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01230-4 · Cited by 75
Qin, B., Polansky, M. M., & Anderson, R. A. (2009) · Hormone and Metabolic Research · doi:10.1055/s-0029-1242746 · Cited by 67
Zaitone, S. A., Hassan, N., El-Orabi, N. F., & El‐Awady, E. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.04.049 · Cited by 64
Mullerwieland, D., Behnke, B., Koopmann, K., & Krone, W. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2198 · Cited by 64 · cited 1×
“Such an improving effect of melatonin on dyslipidemia and hepatic steatosis in rats with high fructose intake may be attributed to the following actions of the indoleamine: the catabolism to bile acid [54], inhibition of cholesterol synthesis and low-density lipoprotein receptor activity [55], and direct actions on th…”
BackgroundAdiponectin and Leptin in Relation to Insulin Sensitivity
Soodini, G. R., & Hamdy, O. (2004) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2004.2.114 · Cited by 48
Behr‐Roussel, D., Oudot, A., Caisey, S., Coz, O. L., Gorny, D., Bernabé, J., Wayman, C. P., Alexandre, L., & Giuliano, F. (2007) · European Urology · doi:10.1016/j.eururo.2007.11.018 · Cited by 47
Baydaş, G., Yılmaz, Ö., Çeli̇k, S., Yaşar, A., & Gürsu, M. F. (2002) · Archives of Medical Research · doi:10.1016/s0188-4409(02)00414-9 · Cited by 46
The Role of Melatonin in the Pathogenesis of Hypertension in Rats With Metabolic Syndrome
Leibowitz, A., Peleg, E., Sharabi, Y., Shabtay, Z., Shamiss, A., & Grossman, E. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2007.60 · Cited by 45
Metabolic Stress with a High Carbohydrate Diet Increases Adiponectin Levels
Kamari, Y., Grossman, E., Oron‐Herman, M., Peleg, E., Shabtay, Z., Shamiss, A., & Sharabi, Y. (2007) · Hormone and Metabolic Research · doi:10.1055/s-2007-976534 · Cited by 35
Nadler, J. L., & Scott, S. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1944 · Cited by 29
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Metadata
- Authors
- Kitagawa, A., Ohta, Y., & Ohashi, K.
- Affiliations
- Shigakkan University (JP)
- Fujita Health University (JP)
- Corresponding author
- Ohta, Yoshiji
- ORCID
- Kitagawa, Akira
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 2012-05
- Volume
- 52
- Issue
- 4
- Pages
- 403-413
- ISSN
- 0742-3098 (ISSN-L)
- 1600-079X
- OpenAlex
- W2101370818
- Cited by
- 116
- References
- 58
- Citations by year
- 2025: 2 · 2024: 7 · 2023: 5 · 2022: 4 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 9 · 2017: 18 · 2016: 6 · 2015: 6 · 2014: 18 · 2013: 11 · 2012: 5
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pineal Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- melatonin, metabolic syndrome, high-fructose diet, insulin resistance, glucose tolerance, lipid metabolism, adiponectin, leptin, TNF-α, oxidative stress, liver cholesterol, intra-abdominal fat
- MeSH terms
- Analysis of Variance, Animals, Antioxidants, Blood Glucose, Body Weight, Cholesterol, Diet, Fructose, Glucose Tolerance Test, Insulin, Insulin Resistance, Lipid Peroxides, Lipids, Liver, Male, Melatonin, Uric Acid, Rats, Wistar, Oxidative Stress, Metabolic Syndrome, Rats, Adipokines
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