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Porcine ear skin: an in vitro model for human skin
Abstract
Background/purpose: Porcine ear skin is used in studies of percutaneous penetration as a substitute for human skin. The structure of this tissue, including hair follicles, was studied qualitatively and quantitatively in comparison with human skin. Methods: Sections of shock‐frozen biopsies, biopsies embedded in paraffin and cyanoacrylate skin surface biopsies were investigated using microscopy. The thickness of the different skin layers and the follicular characteristics were determined. Results: The thickness of the stratum corneum was 17–28 μm, whereas the viable epidermis was 60–85 μm thick. On 1 cm 2, 11–25 hairs were detected, showing a diameter of 58–97 μm and a maximal extension depth of 0.96–1.38 mm into the skin. The orifices of the porcine infundibula showed a diameter of approximately 200 μm. Conclusions: The results obtained are similar to those of human skin, indicating the suitability of this porcine tissue as a model for human skin.
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Cited by
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El Maghraby, G. M., Barry, B. W., & Williams, A. C. (2008) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2008.05.002 · Cited by 623
Kim, E. A., Park, J. S., Kim, M. S., Jeong, M. Y., Park, H. J., Choi, J. H., Seo, J. H., Choi, Y. S., & Kang, M. J. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s335039 · Cited by 32
Langasco, R., Tanrıverdi, S. T., Özer, Ö., Roldo, M., Cossu, M., Rassu, G., Giunchedi, P., & Gavini, E. (2018) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2017.1395458 · Cited by 25
Metadata
- Authors
- Jacobi, U., Kaiser, M., Toll, R., Mangelsdorf, S., Audring, H., Otberg, N., Sterry, W., & Lademann, J.
- Venue
- Skin Research and Technology
- Publisher
- Wiley
- Published
- 2006-12-14
- Volume
- 13
- Issue
- 1
- Pages
- 19-24
- ISSN
- 0909-752X (ISSN-L)
- 1600-0846
- OpenAlex
- W2152312983
- Cited by
- 536
- References
- 0
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jacobi, U., Kaiser, M., Toll, R., Mangelsdorf, S., Audring, H., Otberg, N., Sterry, W., & Lademann, J. (2007). Porcine ear skin: an in vitro model for human skin. Skin Research and Technology. https://doi.org/10.1111/j.1600-0846.2006.00179.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
