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Cited by 376Cellular transport and secretionAutophagy in Disease and TherapyUbiquitin and proteasome pathways

A Protein's Final ESCRT

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Babst, Markus·2005·Traffic
DOI 10.1111/j.1600-0854.2004.00246.x
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Abstract

In eukaryotic cells, delivery of transmembrane proteins into the lumen of the lysosome for degradation is mediated by the multivesicular body pathway. The function of the ESCRT protein complexes is required for both the formation of multivesicular body lumenal vesicles and the sorting of endosomal cargo proteins into these vesicles. Recent studies have identified additional factors that seem to function as an upstream cargo retention system feeding into the ESCRT machinery, given new insights into the dynamic structure of multivesicular bodies, and identified a potential mechanism for multivesicular body vesicle formation.

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  • ILV formation requires two distinct processes: organization of the endosome membrane into tetraspanin-enriched microdomains (TEMs) and ESCRT complexes.

    “Work in yeast [28-31] and other tissue culture models [32-34] suggests that ILV formation requires two distinct processes. The first involves the organization of the endosome membrane into specialized units highly enriched for a class of membrane proteins called tetraspanins [35].”

    From Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013) · cites this paper as [31]

    The Abstract (page not supplied) states that ESCRT complexes are required for the formation of multivesicular-body lumenal vesicles. The paper does not identify tetraspanin-enriched microdomains as a second required process; its MVB Vesicle Formation and Dynamics section instead discusses a possible role for lipids in membrane invagination. (LLM, conf=0.88)

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Research works printed but not linked: 59

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Cited by

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Authors
Babst, M.
Affiliations
University of Utah (US)
Corresponding author
Babst, Markus
ORCID
Babst, Markus
Venue
Traffic
Publisher
Wiley
Published
2004-11-25
Volume
6
Issue
1
Pages
2-9
ISSN
  • 1398-9219 (ISSN-L)
  • 1600-0854
DOI
10.1111/j.1600-0854.2004.00246.x
OpenAlex
W2095798079
Cited by
376
References
0
Citations by year
2026: 5 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 10 · 2018: 10 · 2017: 6 · 2016: 4 · 2015: 9 · 2014: 12 · 2013: 8 · 2012: 29
FWCI
3.26
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Traffic (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords
ESCRT machinery, multivesicular bodies, lysosomal degradation, vesicle formation, endocytosis
MeSH terms
Animals, Eukaryotic Cells, Humans, Lysosomes, Models, Biological, Endosomes, Vacuoles, Protein Transport, Ubiquitin, Vesicular Transport Proteins

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