Cited by 238Cellular transport and secretionUbiquitin and proteasome pathwaysAutophagy in Disease and Therapy

Endosomal and non-endosomal functions of ESCRT proteins

Slagsvold, Thomas, Pattni, Krupa, Malerød, Lene, Stenmark, Harald·2006·Trends in Cell Biology

Abstract

The three endosomal sorting complexes required for transport (ESCRTs) are integral to the degradation of endocytosed membrane proteins and multivesicular body (MVB) biogenesis. Here, we review evidence that ESCRTs have evolved as a specialized machinery for the degradative sorting of ubiquitinated membrane proteins and we highlight recent studies that have shed light on the mechanisms by which these complexes mediate protein sorting, MVB biogenesis, tumour suppression and viral budding. We also discuss evidence that some ESCRT subunits have evolved additional functions that are unrelated to membrane trafficking.

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Crossref · 10.1016/j.tcb.2006.04.004

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  • ILV formation requires two distinct processes: organization of the endosome membrane into tetraspanin-enriched microdomains (TEMs) and ESCRT complexes.

    “Work in yeast [28-31] and other tissue culture models [32-34] suggests that ILV formation requires two distinct processes. The first involves the organization of the endosome membrane into specialized units highly enriched for a class of membrane proteins called tetraspanins [35].”

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Authors
Slagsvold, T., Pattni, K., Malerød, L., & Stenmark, H.
Affiliations
University of Oslo (NO)
Corresponding author
Stenmark, Harald
Venue
Trends in Cell Biology
Publisher
Elsevier BV
Published
2006-06
Volume
16
Issue
6
Pages
317-326
ISSN
0962-8924 (ISSN-L)
OpenAlex
W2020212191
Cited by
238
References
92
Citations by year
2026: 6 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 6 · 2017: 6 · 2016: 3 · 2015: 4 · 2014: 9 · 2013: 5 · 2012: 18
FWCI
3.31
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
ESCRT proteins, multivesicular body biogenesis, ubiquitin-mediated proteolysis, membrane protein sorting, tumor suppression, viral budding
MeSH terms
Tsg101 Protein, Animals, DNA-Binding Proteins, Humans, Models, Biological, Protein Processing, Post-Translational, Endosomes, Transcription Factors, Virus Physiological Phenomena, Evolution, Molecular, Protein Transport, Transport Vesicles, Tumor Suppressor Proteins, Ubiquitin, Vesicular Transport Proteins, Multiprotein Complexes, Endosomal Sorting Complexes Required for Transport

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