The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
Tetraspanins as Regulators of Protein Trafficking
Abstract
Small transmembrane proteins of the tetraspanin superfamily are believed to function as the main structural blocks of specialized membrane microdomains (referred to as tetraspanin‐enriched microdomains, TERM or TEM). Through a multitude of homotypic and heterotypic interactions, tetraspanins regulate lateral clustering and, consequently, signalling involving adhesion and growth factor receptors as well as costimulatory proteins. The presence of major histocompatibility complex (MHC) I and MHCII molecules in TERM led to suggestion of tetraspanins’ involvement in antigen presentation. In addition, certain tetraspanins function as viral co‐receptors and may be important for viral egress from infected cells. It has recently become apparent that in addition to their purely structural function as organizers of TERM, tetraspanins also regulate various aspects of trafficking and biosynthetic processing of associated receptors. Here, we review recent studies, which specifically focus on this issue.
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Cites
Signals for Sorting of Transmembrane Proteins to Endosomes and Lysosomes
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Tetraspanin functions and associated microdomains
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“However, the PKCa-dependent internalization of b1 integrins seems to proceed through caveoli and/or Triton-X-100-resistant microdomains (55), which in most cells exclude tetraspanins (3).”
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Cited by
Trafficking and function of the tetraspanin CD63
Pols, M. S., & Klumperman, J. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.09.020 · Cited by 745
Perez-Hernandez, D., Gutiérrez-Vázquez, C., Jorge, I., López-Martín, S., Ursa, A., Sánchez-Madrid, F., Vázquez, J., & Yáñez-Mó, M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.445304 · Cited by 532
ALIX- and ESCRT-III–dependent sorting of tetraspanins to exosomes
Larios, J., Mercier, V., Roux, A., & Gruenberg, J. (2020) · Journal of Cell Biology · doi:10.1083/jcb.201904113 · Cited by 422
Shedding Light on Extracellular Vesicle Biogenesis and Bioengineering
Teng, F., & Fussenegger, M. (2021) · Advanced Science · doi:10.1002/advs.202003505 · Cited by 382
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Metadata
- Authors
- Berditchevski, F., & Odintsova, E.
- Venue
- Traffic
- Publisher
- Wiley
- Published
- 2006-11-20
- Volume
- 8
- Issue
- 2
- Pages
- 89-96
- ISSN
- 1398-9219 (ISSN-L)
- 1600-0854
- OpenAlex
- W2031392025
- Cited by
- 296
- References
- 112
- FWCI
- 10.36
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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