ALIX- and ESCRT-III–dependent sorting of tetraspanins to exosomes

Shedding light on the cell biology of extracellular vesicles

van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369 · see citing works

Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766 · see citing works

Membrane vesicles as conveyors of immune responses

Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,869 · see citing works

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,639 · see citing works

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

Tkach, M., & Théry, C. (2016) · Cell · doi:10.1016/j.cell.2016.01.043 · Cited by 3,444 · see citing works

Exosomes – vesicular carriers for intercellular communication

Simons, M., & Raposo, G. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.03.007 · Cited by 2,351 · see citing works

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

Baietti, M. F., Zhang, Z., Mortier, E., Melchior, A., Degeest, G., Geeraerts, A., Ivarsson, Y., Depoortere, F., Coomans, C., Vermeiren, E., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2502 · Cited by 1,899 · see citing works

Biogenesis and secretion of exosomes

Kowal, J., Tkach, M., & Théry, C. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.05.004 · Cited by 1,781 · see citing works

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

Colombo, M., Moita, C. F., van Niel, G., Kowal, J., Vigneron, J., Benaroch, P., Manel, N., Moita, L. F., Théry, C., & Raposo, G. (2013) · Journal of Cell Science · doi:10.1242/jcs.128868 · Cited by 1,472 · see citing works

Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I

Katzmann, D. J., Babst, M., & Emr, S. D. (2001) · Cell · doi:10.1016/s0092-8674(01)00434-2 · Cited by 1,430 · see citing works

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

Raiborg, C., & Stenmark, H. (2009) · Nature · doi:10.1038/nature07961 · Cited by 1,408 · see citing works

Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding

Garrus, J. E., von Schwedler, U. K., Pornillos, O. W., Morham, S. G., Zavitz, K. H., Wang, H. E., Wettstein, D. A., Stray, K. M., Côté, M., Rich, R. L., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00506-2 · Cited by 1,369 · see citing works

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

Kalra, H., Simpson, R. J., Ji, H., Aikawa, E., Altevogt, P., Askenase, P., Bond, V. C., Borràs, F. E., Breakefield, X., Budnik, V., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001450 · Cited by 1,367 · see citing works

Nuclear envelope rupture and repair during cancer cell migration

Denais, C. M., Gilbert, R. M., Isermann, P., McGregor, A. L., te Lindert, M., Weigelin, B., Davidson, P. M., Friedl, P., Wolf, K., & Lammerding, J. (2016) · Science · doi:10.1126/science.aad7297 · Cited by 1,318 · see citing works

Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software

Kamentsky, L. D., Jones, T. R., Fraser, A. N., Bray, M., Logan, D. J., Madden, K. L., Ljosa, V., Rueden, C., Eliceiri, K. W., & Carpenter, A. E. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr095 · Cited by 1,002 · see citing works

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

van Niel, G., Charrin, S., Simoes, S., Romao, M., Rochin, L., Säftig, P., Marks, M. S., Rubinstein, E., & Raposo, G. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.08.019 · Cited by 955 · see citing works

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

Raab, M., Gentili, M., Belly, H. D., Thiam, H. R., Vargas, P., Jiménez, A. J., Lautenschläger, F., Voituriez, R., Lennon‐Duménil, A., Manel, N., et al. (2016) · Science · doi:10.1126/science.aad7611 · Cited by 946 · see citing works

Escrt-III

Babst, M., Katzmann, D. J., Estepa, E. J., Meerloo, T., & Emr, S. D. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00220-4 · Cited by 875 · see citing works

Breaking the chains: deubiquitylating enzyme specificity begets function

Clague, M. J., Urbé, S., & Komander, D. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0099-1 · Cited by 839 · see citing works

AIP1/ALIX Is a Binding Partner for HIV-1 p6 and EIAV p9 Functioning in Virus Budding

Strack, B., Calistri, A., Craig, S., Popova, E., & Göttlinger, H. G. (2003) · Cell · doi:10.1016/s0092-8674(03)00653-6 · Cited by 825 · see citing works

A lipid associated with the antiphospholipid syndrome regulates endosome structure and function

Kobayashi, T., Stang, E., Fang, K. S., de Moerloose, P., Parton, R. G., & Gruenberg, J. (1998) · Nature · doi:10.1038/32440 · Cited by 787 · see citing works

Ubiquitination of a Yeast Plasma Membrane Receptor Signals Its Ligand-Stimulated Endocytosis

Hicke, L., & Riezman, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80982-4 · Cited by 783 · see citing works

Parallels Between Cytokinesis and Retroviral Budding: A Role for the ESCRT Machinery

Carlton, J. G., & Martin-Serrano, J. (2007) · Science · doi:10.1126/science.1143422 · Cited by 764 · see citing works

The emerging shape of the ESCRT machinery

Williams, R. L., & Urbé, S. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2162 · Cited by 747 · see citing works

Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis

Morita, E., Sandrin, V., Chung, H., Morham, S. G., Gygi, S. P., Rodesch, C. K., & Sundquist, W. I. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601850 · Cited by 724 · see citing works

HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress

Martin-Serrano, J., Zang, T., & Bieniasz, P. D. (2001) · Nature Medicine · doi:10.1038/nm1201-1313 · Cited by 710 · see citing works

Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization

Matsuo, H., Chevallier, J., Mayran, N., Le Blanc, I., Ferguson, C., Fauré, J., Blanc, N. S., Matile, S., Dubochet, J., Sadoul, R., et al. (2004) · Science · doi:10.1126/science.1092425 · Cited by 705 · see citing works

ESCRT Machinery Is Required for Plasma Membrane Repair

Jiménez, A. J., Maiuri, P., Lafaurie-Janvore, J., Divoux, S., Piel, M., & Perez, F. (2014) · Science · doi:10.1126/science.1247136 · Cited by 670 · see citing works

Endosome-Associated Complex, ESCRT-II, Recruits Transport Machinery for Protein Sorting at the Multivesicular Body

Babst, M., Katzmann, D. J., Snyder, W. B., Wendland, B., & Emr, S. D. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00219-8 · Cited by 662 · see citing works

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

Peters, P. J., Neefjes, J., Oorschot, V. M. J., Ploegh, H. L., & Geuze, H. J. (1991) · Nature · doi:10.1038/349669a0 · Cited by 658 · see citing works

Membrane scission by the ESCRT-III complex

Wollert, T., Wunder, C., Lippincott‐Schwartz, J., & Hurley, J. H. (2009) · Nature · doi:10.1038/nature07836 · Cited by 634 · see citing works

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

Filimonenko, M., Stuffers, S., Raiborg, C., Yamamoto, A., Malerød, L., Fisher, E. M. C., Isaacs, A., Brech, A., Stenmark, H., & Simonsen, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200702115 · Cited by 626 · see citing works

BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals

Poser, I., Sarov, M., Hutchins, J. R. A., Hèriché, J.-K., Toyoda, Y., Pozniakovsky, A., Weigl, D., Nitzsche, A., Hegemann, B., Bird, A. W., et al. (2008) · Nature Methods · doi:10.1038/nmeth.1199 · Cited by 597 · see citing works

Endosome maturation, transport and functions

Scott, C. C., Vacca, F., & Gruenberg, J. E. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.03.034 · Cited by 581 · see citing works

Rab‐interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes

Cantalupo, G., Alifano, P., Roberti, V., Bruni, C. B., & Bucci, C. (2001) · The EMBO Journal · doi:10.1093/emboj/20.4.683 · Cited by 542 · see citing works

Triggered recruitment of ESCRT machinery promotes endolysosomal repair

Skowyra, M. L., Schlesinger, P. H., Naismith, T. V., & Hanson, P. I. (2018) · Science · doi:10.1126/science.aar5078 · Cited by 537 · see citing works

The Intracellular Interactome of Tetraspanin-enriched Microdomains Reveals Their Function as Sorting Machineries toward Exosomes

Pérez-Hernández, D., Gutiérrez‐Vázquez, C., Jorge, I., López‐Martín, S., Ursa, Á., Sánchez‐Madrid, F., Vázquez, J., & Yáñez‐Mó, M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.445304 · Cited by 534 · see citing works

CD81 (TAPA-1): A MOLECULE INVOLVED IN SIGNAL TRANSDUCTION AND CELL ADHESION IN THE IMMUNE SYSTEM

Levy, S., Todd, S. C., & Maecker, H. T. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.89 · Cited by 514 · see citing works

Cortical Constriction During Abscission Involves Helices of ESCRT-III–Dependent Filaments

Guizetti, J., Schermelleh, L., Mäntler, J., Maar, S., Poser, I., Leonhardt, H., Müller-Reichert, T., & Gerlich, D. (2011) · Science · doi:10.1126/science.1201847 · Cited by 496 · see citing works

ESCRT-III Dysfunction Causes Autophagosome Accumulation and Neurodegeneration

Lee, J., Beigneux, A. P., Ahmad, S. T., Young, S. G., & Gao, F. (2007) · Current Biology · doi:10.1016/j.cub.2007.07.029 · Cited by 490 · see citing works

Interfering with Apoptosis: Ca 2+ -Binding Protein ALG-2 and Alzheimer's Disease Gene ALG-3

Vito, P., Lacaná, E., & D'adamio, L. (1996) · Science · doi:10.1126/science.271.5248.521 · Cited by 468 · see citing works

Vps27 recruits ESCRT machinery to endosomes during MVB sorting

Katzmann, D. J., Stefan, C. J., Babst, M., & Emr, S. D. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302136 · Cited by 455 · see citing works

ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival

Radulovic, M., Bongiovanni, A., Schink, K., Nähse, V., Wenzel, E. M., Lafont, F., & Stenmark, H. (2018) · bioRxiv · doi:10.15252/embj.201899753 · Cited by 423 · see citing works

Separation and Characterization of Late Endosomal Membrane Domains

Kobayashi, T., Beuchat, M.-H., Chevallier, J., Makino, A., Mayran, N., Escola, J.-M., Lebrand, C., Cosson, P., Kobayashi, T., & Gruenberg, J. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202838200 · Cited by 409 · see citing works

Dynamics of endosomal sorting complex required for transport (ESCRT) machinery during cytokinesis and its role in abscission

Elia, N., Sougrat, R., Spurlin, T. A., Hurley, J. H., & Lippincott‐Schwartz, J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102714108 · Cited by 389 · see citing works

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

Vietri, M., Schink, K. O., Campsteijn, C., Wegner, C. S., Schultz, S. W., Christ, L., Thoresen, S. B., Brech, A., Raiborg, C., & Stenmark, H. (2015) · Nature · doi:10.1038/nature14408 · Cited by 378 · see citing works

Mechanisms of pathogen entry through the endosomal compartments

Gruenberg, J., & van der Goot, F. G. (2006) · Nature reviews. Molecular cell biology · doi:10.1038/nrm1959 · Cited by 360 · see citing works

Mechanism of Ca2+-triggered ESCRT assembly and regulation of cell membrane repair

Scheffer, L., Sreetama, S. C., Sharma, N., Medikayala, S., Brown, K. J., Defour, A., & Jaiswal, J. K. (2014) · Nature Communications · doi:10.1038/ncomms6646 · Cited by 358 · see citing works

ESCRT-III controls nuclear envelope reformation

Olmos, Y., Hodgson, L. R., Mantell, J., Verkade, P., & Carlton, J. G. (2015) · Nature · doi:10.1038/nature14503 · Cited by 355 · see citing works

Helical Structures of ESCRT-III Are Disassembled by VPS4

Lata, S., Schoehn, G., Jain, A., Vieira-Pires, R. S., Piehler, J., Göttlinger, H. G., & Weissenhorn, W. (2008) · Science · doi:10.1126/science.1161070 · Cited by 352 · see citing works

Late endosome motility depends on lipids via the small GTPase Rab7

Lebrand, C., Felberbaum‐Corti, M., Goodson, H. V., Cosson, P., Cavalli, V., Mayran, N., Fauré, J., & Gruenberg, J. E. (2002) · The EMBO Journal · doi:10.1093/emboj/21.6.1289 · Cited by 338 · see citing works

Ordered Assembly of the ESCRT-III Complex on Endosomes Is Required to Sequester Cargo during MVB Formation

Teis, D., Saksena, S., & Emr, S. D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.08.013 · Cited by 338 · see citing works

Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation

Chiaruttini, N., Redondo‐Morata, L., Colom, A., Humbert, F., Lenz, M., Simon Scheuring, A., & Roux, A. (2015) · Cell · doi:10.1016/j.cell.2015.10.017 · Cited by 331 · see citing works

Pmel17 initiates premelanosome morphogenesis within multivesicular bodies

Berson, J. F., Harper, D. C., Tenza, D., Raposo, G., & Marks, M. S. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.11.3451 · Cited by 326 · see citing works

ALIX and the multivesicular endosome: ALIX in Wonderland

Bissig, C., & Gruenberg, J. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.10.009 · Cited by 323 · see citing works

The ABC‐transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants.

Kölling, R., & Hollenberg, C. P. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06627.x · Cited by 320 · see citing works

Structural and Biochemical Studies of ALIX/AIP1 and Its Role in Retrovirus Budding

Fisher, R. D., Chung, H.-Y., Zhai, Q., Robinson, H., Sundquist, W. I., & Hill, C. P. (2007) · Cell · doi:10.1016/j.cell.2007.01.035 · Cited by 315 · see citing works

Tetraspanins as Regulators of Protein Trafficking

Berditchevski, F., & Odintsova, E. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00515.x · Cited by 296 · see citing works

Functional Reconstitution of ESCRT-III Assembly and Disassembly

Saksena, S., Wahlman, J., Teis, D., Johnson, A. E., & Emr, S. D. (2009) · Cell · doi:10.1016/j.cell.2008.11.013 · Cited by 296 · see citing works

A Lumenal Domain-Dependent Pathway for Sorting to Intralumenal Vesicles of Multivesicular Endosomes Involved in Organelle Morphogenesis

Theos, A. C., Truschel, S. T., Tenza, D., Hurbain, I., Harper, D. C., Berson, J. F., Thomas, P. C., Raposo, G., & Marks, M. S. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.01.012 · Cited by 289 · see citing works

Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells

Kleijmeer, M. J., Ramm, G., Schuurhuis, D. H., Griffith, J. M., Rescigno, M., Ricciardi‐Castagnoli, P., Rudensky, A. Y., OSSENDORP, F. A., Melief, C. J. M., Stoorvogel, W., et al. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200103071 · Cited by 288 · see citing works

Characterization of novel complexes on the cell surface between integrins and proteins with 4 transmembrane domains (TM4 proteins).

Berditchevski, F., Zutter, M. M., & Hemler, M. E. (1996) · Molecular Biology of the Cell · doi:10.1091/mbc.7.2.193 · Cited by 274 · see citing works

Lysosome-related organelles: unusual compartments become mainstream

Marks, M. S., Heijnen, H. F. G., & Raposo, G. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.04.008 · Cited by 266 · see citing works

Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein–ubiquitin conjugates

Bishop, N. E., Horman, A., & Woodman, P. G. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200112080 · Cited by 266 · see citing works

Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis

Mierzwa, B. E., Chiaruttini, N., Redondo‐Morata, L., von Filseck, J. M., König, J., Larios, J., Poser, I., Müller‐Reichert, T., Simon Scheuring, A., Roux, A., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3559 · Cited by 252 · see citing works

Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein

Missotten, M., Nichols, A., Rieger, K., & Sadoul, R. (1999) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400456 · Cited by 239 · see citing works

Cloning of AIP1, a Novel Protein That Associates with the Apoptosis-linked Gene ALG-2 in a Ca2+-dependent Reaction

Vito, P., Pellegrini, L., Guiet, C., & D'adamio, L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.3.1533 · Cited by 235 · see citing works

Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release

Carlton, J. G., Agromayor, M., & Martin‐Serrano, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802008105 · Cited by 233 · see citing works

ALIX-CHMP4 interactions in the human ESCRT pathway

McCullough, J., Fisher, R. D., Whitby, F. G., Sundquist, W. I., & Hill, C. P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801567105 · Cited by 233 · see citing works

Hrs‐ and CD63 ‐Dependent Competing Mechanisms Make Different Sized Endosomal Intraluminal Vesicles

Edgar, J. R., Eden, E. R., & Futter, C. E. (2013) · Traffic · doi:10.1111/tra.12139 · Cited by 224 · see citing works

Hijacking Multivesicular Bodies Enables Long-Term and Exosome-Mediated Long-Distance Action of Anthrax Toxin

Abrami, L., Brandi, L., Moayeri, M., Brown, M. J., Krantz, B. A., Leppla, S. H., & van der Goot, F. G. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.019 · Cited by 216 · see citing works

The ALG-2-interacting Protein Alix Associates with CHMP4b, a Human Homologue of Yeast Snf7 That Is Involved in Multivesicular Body Sorting

Katoh, K., Shibata, H., Suzuki, H., Nara, A., Ishidoh, K., Kominami, E., Yoshimori, T., & Maki, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301604200 · Cited by 213 · see citing works

Ubiquitin-Dependent Sorting in EndocytosisPreprint

Piper, R. C., Đikić, I., & Lukács, G. L. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016808 · Cited by 209 · see citing works

Exosomes in developmental signalling

McGough, I. J., & Vincent, J. (2016) · Development · doi:10.1242/dev.126516 · Cited by 207 · see citing works

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

Gu, M., LaJoie, D., Chen, O. S., von Appen, A., Ladinsky, M. S., Redd, M. J., Nikolova, L. S., Björkman, P. J., Sundquist, W. I., Ullman, K. S., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613916114 · Cited by 196 · see citing works

Degradation of Endocytosed Epidermal Growth Factor and Virally Ubiquitinated Major Histocompatibility Complex Class I Is Independent of Mammalian ESCRTII

Bowers, K., Piper, S. C., Edeling, M. A., Gray, S. R., Owen, D. J., Lehner, P. J., & Luzio, J. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508632200 · Cited by 187 · see citing works

Exosomes contain ubiquitinated proteins

Buschow, S. I., Liefhebber, J. M. P., Wubbolts, R., & Stoorvogel, W. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.08.005 · Cited by 185 · see citing works

Coordinated binding of Vps4 to ESCRT-III drives membrane neck constriction during MVB vesicle formation

Adell, M. A. Y., Vogel, G. F., Pakdel, M., Müller, M., Lindner, H. H., Hess, M. W., & Teis, D. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201310114 · Cited by 182 · see citing works

How Ubiquitin Functions with ESCRTs

Shields, S. B., & Piper, R. C. (2011) · Traffic · doi:10.1111/j.1600-0854.2011.01242.x · Cited by 175 · see citing works

Structural Basis for Endosomal Targeting by the Bro1 Domain

Kim, J., Sitaraman, S., Hierro, A., Beach, B. M., Odorizzi, G., & Hurley, J. H. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.04.001 · Cited by 174 · see citing works

ALIX binds a YPX3L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting

Dores, M. R., Chen, B., Lin, H., Soh, U. J. K., Paing, M. M., Montagne, W. A., Meerloo, T., & Trejo, J. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201110031 · Cited by 163 · see citing works

ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission

Christ, L., Wenzel, E. M., Liestøl, K., Raiborg, C., Campsteijn, C., & Stenmark, H. (2016) · Journal of Cell Biology · doi:10.1083/jcb.201507009 · Cited by 163 · see citing works

ESCRT‐II coordinates the assembly of ESCRT‐III filaments for cargo sorting and multivesicular body vesicle formation

Teis, D., Saksena, S., Judson, B. L., & Emr, S. D. (2010) · The EMBO Journal · doi:10.1038/emboj.2009.408 · Cited by 162 · see citing works

Electron tomography of early melanosomes: Implications for melanogenesis and the generation of fibrillar amyloid sheets

Hurbain, I., Geerts, W. J. C., Boudier, T., Marco, S., Verkleij, A. J., Marks, M. S., & Raposo, G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803488105 · Cited by 160 · see citing works

Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments

Tang, S., Henne, W. M., Borbat, P. P., Buchkovich, N. J., Freed, J. H., Mao, Y., Fromme, J. C., & Emr, S. D. (2015) · eLife · doi:10.7554/elife.12548 · Cited by 156 · see citing works

The Bro1-related protein HD-PTP/PTPN23 is required for endosomal cargo sorting and multivesicular body morphogenesis

Doyotte, A., Mironov, A., McKenzie, E., & Woodman, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707601105 · Cited by 154 · see citing works

Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding

Adell, M. A. Y., Migliano, S. M., Upadhyayula, S., Bykov, Y. S., Sprenger, S., Pakdel, M., Vogel, G. F., Jih, G. T., Skillern, W., Behrouzi, R., et al. (2017) · eLife · doi:10.7554/elife.31652 · Cited by 154 · see citing works

Lysosome-related organelles as functional adaptations of the endolysosomal system

Delevoye, C., Marks, M. S., & Raposo, G. (2019) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2019.05.003 · Cited by 147 · see citing works

Potent Rescue of Human Immunodeficiency Virus Type 1 Late Domain Mutants by ALIX/AIP1 Depends on Its CHMP4 Binding Site

Usami, Y., Popov, S., & Göttlinger, H. G. (2007) · Journal of Virology · doi:10.1128/jvi.00314-07 · Cited by 143 · see citing works

Apolipoprotein E Regulates Amyloid Formation within Endosomes of Pigment Cells

van Niel, G., Bergam, P., Cicco, A. D., Hurbain, I., Cicero, A. L., Dingli, F., Palmulli, R., Fort, C., Potier, M., Schurgers, L. J., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.057 · Cited by 143 · see citing works

A Crescent-Shaped ALIX Dimer Targets ESCRT-III CHMP4 Filaments

Vieira-Pires, R. S., Hartlieb, B., Signor, L., Schoehn, G., Lata, S., Roessle, M. W., Moriscot, C., Popov, S., Hinz, A., Jamin, M., et al. (2009) · Structure · doi:10.1016/j.str.2009.04.007 · Cited by 138 · see citing works

Identification and characterization of EGF receptor in individual exosomes by fluorescence‐activated vesicle sorting

Higginbotham, J. N., Zhang, Q., Jeppesen, D. K., Scott, A. M., Manning, H. C., Ochieng, J., Franklin, J. L., & Coffey, R. J. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.29254 · Cited by 133 · see citing works

Membrane Binding by CHMP7 Coordinates ESCRT-III-Dependent Nuclear Envelope Reformation

Olmos, Y., Perdrix-Rosell, A., & Carlton, J. G. (2016) · Current Biology · doi:10.1016/j.cub.2016.07.039 · Cited by 132 · see citing works

The ESCRT and autophagy machineries cooperate to repair ESX-1-dependent damage at the Mycobacterium-containing vacuole but have opposite impact on containing the infection

López-Jiménez, A. T., Cardenal‐Muñoz, E., Leuba, F., Gerstenmaier, L., Barisch, C., Hagedorn, M., King, J., & Soldati, T. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007501 · Cited by 132 · see citing works

Structural analysis and modeling reveals new mechanisms governing ESCRT-III spiral filament assembly

Shen, Q.-T., Schuh, A. L., Zheng, Y., Quinney, K., Wang, L., Hanna, M., Mitchell, J. C., Otegui, M. S., Ahlquist, P., Cui, Q., et al. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201403108 · Cited by 129 · see citing works

Post-translational add-ons mark the path in exosomal protein sorting

Moreno-Gonzalo, O., Fernández‐Delgado, I., & Sánchez‐Madrid, F. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2690-y · Cited by 128 · see citing works

Viral Infection Controlled by a Calcium-Dependent Lipid-Binding Module in ALIX

Bissig, C., Lenoir, M., Velluz, M., Kufareva, I., Abagyan, R. A., Overduin, M., & Gruenberg, J. E. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.04.003 · Cited by 126 · see citing works

Molecular interactions shaping the tetraspanin web

van Deventer, S. J., Dunlock, V.-M. E., & van Spriel, A. B. (2017) · Biochemical Society Transactions · doi:10.1042/bst20160284 · Cited by 126 · see citing works

Recruitment of UBPY and ESCRT Exchange Drive HD-PTP-Dependent Sorting of EGFR to the MVB

Ali, N., Zhang, L., Taylor, S., Mironov, A., Urbé, S., & Woodman, P. G. (2013) · Current Biology · doi:10.1016/j.cub.2013.02.033 · Cited by 121 · see citing works

Alix/AIP1 Antagonizes Epidermal Growth Factor Receptor Downregulation by the Cbl-SETA/CIN85 Complex

Schmidt, M. H. H., Hoeller, D., Yu, J., Furnari, F. B., Cavenee, W. K., Đikić, I., & Bögler, O. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.8981-8993.2004 · Cited by 121 · see citing works

Spatial Separation of HLA-DM/HLA-DR Interactions within MIIC and Phagosome-Induced Immune Escape

Zwart, W. T., Griekspoor, A., Kuijl, C. P., Marsman, M., van Rheenen, J., Janssen, H., Calafat, J., van Ham, S. M., Janssen, L., van Lith, M., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.01.006 · Cited by 117 · see citing works

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

Guix, F. X., Sannerud, R., Berditchevski, F., Arranz, A. M., Horré, K., Snellinx, A., Thathiah, A., Saido, T. C., Saito, T., Rajesh, S., et al. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0165-0 · Cited by 98 · see citing works

The Yeast Alix Homolog Bro1 Functions as a Ubiquitin Receptor for Protein Sorting into Multivesicular Endosomes

Pashkova, N., Gakhar, L., Winistorfer, S. C., Sunshine, A. B., Rich, M. S., Dunham, M. J., Yu, L. P., & Piper, R. C. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.04.007 · Cited by 94 · see citing works

Alix, a Protein Regulating Endosomal Trafficking, Is Involved in Neuronal Death

Trioulier, Y., Torch, S., Blot, B., Cristina, N., Chatellard, C., Verna, J., & Sadoul, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309243200 · Cited by 94 · see citing works

ALIX Is a Lys63-Specific Polyubiquitin Binding Protein that Functions in Retrovirus Budding

Dowlatshahi, D. P., Sandrin, V., Vivona, S., Shaler, T. A., Kaiser, S. E., Melandri, F. D., Sundquist, W. I., & Kopito, R. R. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.10.023 · Cited by 86 · see citing works

ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis

Tang, S., Buchkovich, N. J., Henne, W. M., Banjade, S., Kim, Y. J., & Emr, S. D. (2016) · eLife · doi:10.7554/elife.15507 · Cited by 84 · see citing works

Tetraspanin CD9 stabilizes gp130 by preventing its ubiquitin-dependent lysosomal degradation to promote STAT3 activation in glioma stem cells

Shi, Y., Zhou, W., Cheng, L., Chen, C., Huang, Z., Fang, X., Wu, Q., He, Z., Xu, S., Lathia, J. D., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.110 · Cited by 82 · see citing works

Endosomal vesicles as vehicles for viral genomes

Nour, A. M., & Modis, Y. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.03.006 · Cited by 70 · see citing works

Structure‐based in silico identification of ubiquitin‐binding domains provides insights into the ALIX‐V:ubiquitin complex and retrovirus budding

Keren‐Kaplan, T., Attali, I., Estrin, M., Kuo, L. S., Farkash, E., Jerabek‐Willemsen, M., Wertheimer, N. B., Artzi, S., Peri, A., Freed, E. O., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.4 · Cited by 67 · see citing works

Metastasis Suppressor Tetraspanin CD82/KAI1 Regulates Ubiquitylation of Epidermal Growth Factor Receptor

Odintsova, E., van Niel, G., Conjeaud, H., Raposo, G., Iwamoto, R., Mekada, E., & Berditchevski, F. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.439380 · Cited by 66 · see citing works

Functional Replacement of a Retroviral Late Domain by Ubiquitin Fusion

Joshi, A., Munshi, U. M., Ablan, S. D., Nagashima, K., & Freed, E. O. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00817.x · Cited by 66 · see citing works

Evidence that the endosomal sorting complex required for transport-II (ESCRT-II) is required for efficient human immunodeficiency virus-1 (HIV-1) production

Meng, B., Ip, N. C. Y., Prestwood, L. J., Abbink, T. E. M., & Lever, A. M. L. (2015) · Retrovirology · doi:10.1186/s12977-015-0197-x · Cited by 65 · see citing works

The ESCRT‐I Subunit TSG101 Controls Endosome‐to‐Cytosol Release of Viral RNA

Luyet, P., Falguières, T., Pons, V., Pattnaik, A. K., & Gruenberg, J. E. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00820.x · Cited by 63 · see citing works

HD-PTP and Alix share some membrane-traffic related proteins that interact with their Bro1 domains or proline-rich regions

Ichioka, F., Takaya, E., SUZUKI, H., Kajigaya, S., Buchman, V. L., Shibata, H., & Maki, M. (2006) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.11.008 · Cited by 61 · see citing works

ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y1 Purinergic Receptor via a YPX3L Motif

Dores, M. R., Grimsey, N. J., Mendez, F., & Trejo, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157587 · Cited by 58 · see citing works

ATG12–ATG3 connects basal autophagy and late endosome function

Murrow, L. M., & Debnath, J. (2015) · Autophagy · doi:10.1080/15548627.2015.1040976 · Cited by 55 · see citing works

Activation of the Retroviral Budding Factor ALIX

Zhai, Q., Landesman, M. B., Chung, H.-Y., Dierkers, A., Jeffries, C. M., Trewhella, J., Hill, C. P., & Sundquist, W. I. (2011) · Journal of Virology · doi:10.1128/jvi.02653-10 · Cited by 52 · see citing works

Dynamic and elastic shape transitions in curved ESCRT-III filaments

Chiaruttini, N., & Roux, A. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.07.002 · Cited by 51 · see citing works

Brox, a novel farnesylated Bro1 domain-containing protein that associates with charged multivesicular body protein 4 (CHMP4)

Ichioka, F., Kobayashi, R., Katoh, K., Shibata, H., & Maki, M. (2008) · The FEBS Journal · doi:10.1111/j.1742-4658.2007.06230.x · Cited by 41 · see citing works

Hp95 promotes anoikis and inhibits tumorigenicity of HeLa cells

Wu, Y., Pan, S., Luo, W., Lin, S.-H., & Kuang, J. (2002) · Oncogene · doi:10.1038/sj.onc.1205849 · Cited by 41 · see citing works

Decoding the intrinsic mechanism that prohibits ALIX interaction with ESCRT and viral proteins

Zhou, X., Si, J., Corvera, J., Gallick, G. E., & Kuang, J. (2010) · Biochemical Journal · doi:10.1042/bj20100862 · Cited by 38 · see citing works

Tetraspanin 6 (TSPAN6) Negatively Regulates Retinoic Acid-inducible Gene I-like Receptor-mediated Immune Signaling in a Ubiquitination-dependent Manner

Wang, Y., Tong, X., Omoregie, E. S., Liu, W., Meng, S., & Ye, X. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.390401 · Cited by 35 · see citing works

The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin αvβ3

Yu, F., Lee, C.-Y., Changou, C. A., Cedano-Prieto, D. M., Takada, Y. K., & Takada, Y. (2016) · Biochemical Journal · doi:10.1042/bcj20160998 · Cited by 32 · see citing works

Role of SNX16 in the Dynamics of Tubulo-Cisternal Membrane Domains of Late Endosomes

Brankatschk, B., Pons, V., Parton, R. G., & Gruenberg, J. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021771 · Cited by 30 · see citing works

The CHMP4b- and Src-docking sites in the Bro1 domain are autoinhibited in the native state of Alix

Zhou, X., Pan, S., Sun, L., Corvera, J., Lee, Y.-C., Lin, S.-H., & Kuang, J. (2008) · Biochemical Journal · doi:10.1042/bj20081388 · Cited by 28 · see citing works

The HIV-1 p6/EIAV p9 docking site in Alix is autoinhibited as revealed by a conformation-sensitive anti-Alix monoclonal antibody

Zhou, X., Pan, S., Sun, L., Corvera, J., Lin, S.-H., & Kuang, J. (2008) · Biochemical Journal · doi:10.1042/bj20080642 · Cited by 24 · see citing works

Tetraspan cargo adaptors usher GPI-anchored proteins into multivesicular bodies

MacDonald, C., Stamnes, M. A., Katzmann, D. J., & Piper, R. C. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1100773 · Cited by 15 · see citing works

In Vitro Polymerization of F-actin on Early Endosomes

Muriel, O., Scott, C. C., Larios, J., et al. (2017) · Journal of Visualized Experiments · doi:10.3791/55829 · Cited by 3 · see citing works

Current Knowledge on Exosome Biogenesis, Cargo-Sorting Mechanism and Therapeutic Implications

Xie, S., Zhang, Q., & Jiang, L. (2022) · Membranes · doi:10.3390/membranes12050498 · Cited by 262 · see citing works

The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System

Li, T., Li, X., Han, G., Liang, M., Yang, Z., Zhang, C., Huang, S., Tai, S., & Yu, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010021 · Cited by 110 · see citing works

Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes

Bache, K. G., Brech, A., Mehlum, A., & Stenmark, H. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302131 · Cited by 470 · see citing works

The ESCRT‐I Subunit TSG101 Controls Endosome‐to‐Cytosol Release of Viral RNA

Luyet, P., Falguières, T., Pons, V., Pattnaik, A. K., & Gruenberg, J. E. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00820.x · Cited by 63 · see citing works

The ESCRT-III Subunit hVps24 Is Required for Degradation but Not Silencing of the Epidermal Growth Factor Receptor

Bache, K. G., Stuffers, S., Malerød, L., Slagsvold, T., Raiborg, C., Lechardeur, D., Wälchli, S., Lukács, G. L., Brech, A., & Stenmark, H. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-10-0915 · Cited by 166 · see citing works

Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent endosomal traffic regulates the localization of active Src at focal adhesions

Tu, C., Ortega-Cava, C. F., Winograd, P., Stanton, M. J., Reddi, A. L., Dodge, I. L., Arya, R., Dimri, M., Clubb, R. J., Naramura, M., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009471107 · Cited by 71 · see citing works

Genetic analysis of ESCRT function in Drosophila: a tumour model for human Tsg101

Herz, H., & Bergmann, A. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370204 · Cited by 16 · see citing works