The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Sensory Cilia and Integration of Signal Transduction in Human Health and Disease
Open accessAbstract
The primary cilium is a hallmark of mammalian tissue cells. Recent research has shown that these organelles display unique sets of selected signal transduction modules including receptors, ion channels, effector proteins and transcription factors that relay chemical and physical stimuli from the extracellular environment in order to control basic cellular processes during embryonic and postnatal development, as well as in tissue homeostasis in adulthood. Consequently, defects in building of the cilium or in transport or function of ciliary signal proteins are associated with a series of pathologies, including developmental disorders and cancer. In this review, we highlight recent examples of the mechanisms by which signal components are selectively targeted and transported to the ciliary membrane and we present an overview of the signal transduction pathways associated with primary and motile cilia in vertebrate cells, including platelet‐derived growth factor receptor‐alpha (PDGFRα), hedgehog and Wnt signaling pathways. Finally, we discuss the functions of these cilia‐associated signal transduction pathways and their role in human health and development.
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Chapter Two Intraflagellar Transport (IFT)
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Self-citationThe Aurora kinase family in cell division and cancer
Vader, G., & Lens, S. M. A. (2008) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.07.003 · Cited by 417
Functional dissection of Rab GTPases involved in primary cilium formation
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Bergmann, C., Fliegauf, M., Brüchle, N. O., Frank, V., Olbrich, H., Kirschner, J., Schermer, B., Schmedding, I., Kispert, A., Kränzlin, B., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.02.017 · Cited by 324
Metadata
- Authors
- Christensen, S. T., Pedersen, L. B., Schneider, L., & Satir, P.
- Venue
- Traffic
- Publisher
- Wiley
- Published
- 2006-11-21
- Volume
- 8
- Issue
- 2
- Pages
- 97-109
- ISSN
- 1398-9219 (ISSN-L)
- 1600-0854
- OpenAlex
- W2047596417
- Cited by
- 258
- References
- 16
- FWCI
- 13.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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