Cited by 701Cancer-related Molecular PathwaysHeat shock proteins researchUbiquitin and proteasome pathways

The complexity of p53 stabilization and activation

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Lavin, M F, Gueven, N·2006·Cell Death & Differentiation

Abstract

A number of proteins are activated by stress stimuli but none so spectacularly or with the degree of complexity as the tumour suppressor p53 (human p53 gene or protein). Once stabilized, p53 is responsible for the transcriptional activation of a series of proteins involved in cell cycle control, apoptosis and senescence. This protein is present at low levels in resting cells but after exposure to DNA-damaging agents and other stress stimuli it is stabilized and activated by a series of post-translational modifications that free it from MDM2 (mouse double minute 2 but used interchangeably to denote human also), a ubiquination ligase that ubiquitinates it prior to proteasome degradation. The stability of p53 is also influenced by a series of other interacting proteins. In this review, we discuss the post-translational modifications to p53 in response to different stresses and the consequences of these changes.

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Crossref · 10.1038/sj.cdd.4401925

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102 of 102 references verified0 citation errors · 0 not checkable

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  • p53 activity as an upstream transcription factor of p21 is directly regulated by stress-sensing signalling pathways.

    “Additionally, p53 activity as an upstream transcription factor of p21 is directly regulated by stress-sensing signalling pathways [22].”

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Authors
Lavin, M. F., & Gueven, N.
Affiliations
  • The University of Queensland (AU)
  • QIMR Berghofer Medical Research Institute (AU)
Corresponding author
Lavin, M F
Venue
Cell Death & Differentiation
Published
2006-04-07
Volume
13
Issue
6
Pages
941-950
ISSN
  • 1350-9047 (ISSN-L)
  • 1476-5403
OpenAlex
W1993170641
Cited by
701
References
102
Citations by year
2026: 13 · 2025: 27 · 2024: 26 · 2023: 23 · 2022: 28 · 2021: 30 · 2020: 27 · 2019: 18 · 2018: 25 · 2017: 22 · 2016: 29 · 2015: 27 · 2014: 39 · 2013: 40 · 2012: 45
FWCI
6.05
Type
journal article
Language
en
Open access
Locations
  • Cell Death and Differentiation (publishedVersion)
  • PubMed (publishedVersion)
  • eCite Digital Repository (University of Tasmania) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
Funders
  • National Health and Medical Research Council
  • National Medical Research Council
Topics
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords
p53, MDM2, post-translational modification, protein stabilization, ubiquitination, proteasomal degradation, DNA damage response, stress response, transcriptional activation, apoptosis, cell cycle regulation, senescence, tumour suppressor
MeSH terms
Acetylation, Animals, Cell Cycle, DNA, DNA Damage, Humans, Mutagens, Phosphorylation, Poly(ADP-ribose) Polymerases, Protein Kinases, Protein Processing, Post-Translational, Tumor Suppressor Protein p53, Apoptosis, Ubiquitin, Proto-Oncogene Proteins c-mdm2

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