Chromatin Tethering of Incoming Foamy Virus by the Structural Gag Protein
Open accessAbstract
Retroviruses hijack cellular machineries to productively infect their hosts. During the early stages of viral replication, proviral integration relies on specific interactions between components of the preintegration complex and host chromatin‐bound proteins. Here, analyzing the fate of incoming primate foamy virus, we identify a short domain within the C‐terminus of the structural Gag protein that efficiently binds host chromosomes, by interacting with H2A/H2B core histones. While viral particle production, virus entry and intracellular trafficking are not affected by mutation of this domain, chromosomal attachment of incoming subviral complexes is abolished, precluding proviral integration. We thus highlight a new function of the structural foamy Gag protein as the main tether between incoming subviral complexes and host chromatin prior to integration.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The PFV Gag chromatin binding sequence binds nucleosomes via an acidic patch predominantly composed of core histone H2A/H2B heterodimers.
“The PFV Gag CBS binds nucleosomes via an acidic patch predominantly composed of core histone H2A/H2B heterodimers91,92”
From Structure and function of retroviral integrase (2022) · cites this paper as [91]
The section “The CBS of PFV Gag interacts with core histones H2A/H2B” (p. 6) reports that the PFV Gag CBS associates with H2A and H2B and binds host chromosomes through them. The Discussion (p. 7) cautions that additional factors or other nucleosomal components may be involved. The paper does not identify an acidic patch as the binding site or establish direct binding to an H2A/H2B heterodimer. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
TRIM family proteins: retroviral restriction and antiviral defence
Nisole, S., Stoye, J. P., & Saïb, A. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1248 · Cited by 761 · see citing works
Self-citationHIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human Cells
Cherepanov, P., Maertens, G., Proost, P., Devreese, B., Van Beeumen, J., Engelborghs, Y., De Clercq, E., & Debyser, Z. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209278200 · Cited by 704 · see citing works
Efficient Persistence of Extrachromosomal KSHV DNA Mediated by Latency-Associated Nuclear Antigen
Ballestas, M. E., Chatis, P. A., & Kaye, K. M. (1999) · Science · doi:10.1126/science.284.5414.641 · Cited by 697 · see citing works
A role for LEDGF/p75 in targeting HIV DNA integration
Ciuffi, A., Llano, M., Poeschla, E., Hoffmann, C., Leipzig, J., Shinn, P., Ecker, J. R., & Bushman, F. (2005) · Nature Medicine · doi:10.1038/nm1329 · Cited by 658 · see citing works
The Nucleosomal Surface as a Docking Station for Kaposi's Sarcoma Herpesvirus LANA
Barbera, A. J., Chodaparambil, J. V., Kelley-Clarke, B., Joukov, V., Walter, J. C., Luger, K., & Kaye, K. M. (2006) · Science · doi:10.1126/science.1120541 · Cited by 505 · see citing works
LEDGF/p75 Is Essential for Nuclear and Chromosomal Targeting of HIV-1 Integrase in Human Cells
Maertens, G., Cherepanov, P., Pluymers, W., Busschots, K., De Clercq, E., Debyser, Z., & Engelborghs, Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303594200 · Cited by 493 · see citing works
Freed, E. (2002) · Journal of Virology · doi:10.1128/jvi.76.10.4679-4687.2002 · Cited by 444 · see citing works
You, J., Croyle, J. L., Nishimura, A., Ozato, K., & Howley, P. M. (2004) · Cell · doi:10.1016/s0092-8674(04)00402-7 · Cited by 402 · see citing works
Retroviral DNA integration: viral and cellular determinants of target-site selection
Lewinski, M. K., Yamashita, M., Emerman, M., Ciuffi, A., Marshall, H., Crawford, G., Collins, F., Shinn, P., Leipzig, J., Hannenhalli, S., et al. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020060 · Cited by 364 · see citing works
Braaten, D. C., Franke, E. K., & Luban, J. (1996) · Journal of Virology · doi:10.1128/jvi.70.6.3551-3560.1996 · Cited by 327 · see citing works
The road to chromatin — nuclear entry of retroviruses
Suzuki, Y., & Craigie, R. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1579 · Cited by 287 · see citing works
The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication
Engelman, A., & Cherepanov, P. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000046 · Cited by 231 · see citing works
The control of viral infection by tripartite motif proteins and cyclophilin A
Towers, G. J. (2007) · Retrovirology · doi:10.1186/1742-4690-4-40 · Cited by 211 · see citing works
Derse, D., Crise, B., Li, Y., Princler, G., Lum, N., Stewart, C., McGrath, C. F., Hughes, S., Munroe, D., & Wu, X. (2007) · Journal of Virology · doi:10.1128/jvi.02752-06 · Cited by 179 · see citing works
Cherepanov, P. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkl885 · Cited by 173 · see citing works
Beyond Tsg101: the role of Alix in 'ESCRTing' HIV-1
Fujii, K., Hurley, J. H., & Freed, E. O. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1790 · Cited by 170 · see citing works
Foamy Virus Capsids Require the Cognate Envelope Protein for Particle Export
Pietschmann, T., Heinkelein, M., Heldmann, M., Zentgraf, H., Rethwilm, A., & Lindemann, D. (1999) · Journal of Virology · doi:10.1128/jvi.73.4.2613-2621.1999 · Cited by 153 · see citing works
Nuclear localization of foamy virus Gag precursor protein
Schliephake, A., & Rethwilm, A. (1994) · Journal of Virology · doi:10.1128/jvi.68.8.4946-4954.1994 · Cited by 147 · see citing works
Petit, C., Giron, M.-L., Tobaly-Tapiero, J., Bittoun, P., Réal, É., Jacob, Y., Tordo, N., de Thé, H., & Saı̈b, A. (2003) · Journal of Cell Science · doi:10.1242/jcs.00613 · Cited by 112 · see citing works
Self-citationM‐PMV Capsid Transport Is Mediated by Env/Gag Interactions at the Pericentriolar Recycling Endosome
Sfakianos, J. N., & Hunter, E. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.00126.x · Cited by 111 · see citing works
Sfakianos, J. N., LaCasse, R. A., & Hunter, E. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.00125.x · Cited by 110 · see citing works
Nuclear targeting of incoming human foamy virus Gag proteins involves a centriolar step
Saı̈b, A., Puvion-dutilleul, F., Schmid, M., Peries, J., & de Thé, H. (1997) · Journal of Virology · doi:10.1128/jvi.71.2.1155-1161.1997 · Cited by 108 · see citing works
Self-citationYu, S. F., Edelmann, K., Strong, R. K., Moebes, A., Rethwilm, A., & Linial, M. L. (1996) · Journal of Virology · doi:10.1128/jvi.70.12.8255-8262.1996 · Cited by 107 · see citing works
Improved Primate Foamy Virus Vectors and Packaging Constructs
Heinkelein, M., Dressler, M., Jármy, G., Rammling, M., Imrich, H., Thurow, J., Lindemann, D., & Rethwilm, A. (2002) · Journal of Virology · doi:10.1128/jvi.76.8.3774-3783.2002 · Cited by 105 · see citing works
Barbera, A. J., Ballestas, M. E., & Kaye, K. M. (2003) · Journal of Virology · doi:10.1128/jvi.78.1.294-301.2004 · Cited by 101 · see citing works
Two retrotransposons maintain telomeres in Drosophila
Pardue, M. L., Rashkova, S., Casacuberta, E., DeBaryshe, P. G., George, J. A., & Traverse, K. L. (2005) · Chromosome Research · doi:10.1007/s10577-005-0993-6 · Cited by 91 · see citing works
Retroviral proteins that interact with the host cell cytoskeleton
Naghavi, M. H., & Goff, S. P. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.07.003 · Cited by 83 · see citing works
HIV infection of non-dividing cells: a divisive problem
Fassati, A. (2006) · Retrovirology · doi:10.1186/1742-4690-3-74 · Cited by 80 · see citing works
Ubiquitin-dependent virus particle budding without viral protein ubiquitination
Zhadina, M., McClure, M. O., Johnson, M. C., & Bieniasz, P. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708002104 · Cited by 76 · see citing works
Delelis, O., Lehmann‐Che, J., & Saı̈b, A. (2004) · Current Opinion in Microbiology · doi:10.1016/j.mib.2004.06.009 · Cited by 73 · see citing works
Self-citationSpecific Interaction of a Novel Foamy Virus Env Leader Protein with the N-Terminal Gag Domain
Wilk, T., Geiselhart, V., Frech, M., Fuller, S., Flügel, R., & Löchelt, M. (2001) · Journal of Virology · doi:10.1128/jvi.75.17.7995-8007.2001 · Cited by 72 · see citing works
Accumulation and Intranuclear Distribution of Unintegrated Human Immunodeficiency Virus Type 1 DNA
Bell, P., Montaner, L. J., & Maul, G. G. (2001) · Journal of Virology · doi:10.1128/jvi.75.16.7683-7691.2001 · Cited by 63 · see citing works
Yu, S. F., Eastman, S. W., & Linial, M. L. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00448.x · Cited by 59 · see citing works
Wong, L.-Y., Matchett, G. A., & Wilson, A. C. (2004) · Journal of Virology · doi:10.1128/jvi.78.18.10074-10085.2004 · Cited by 57 · see citing works
Butterfield-Gerson, K. L., Scheifele, L. Z., Ryan, E. P., Hopper, A. K., & Parent, L. J. (2006) · Journal of Virology · doi:10.1128/jvi.80.4.1798-1806.2006 · Cited by 57 · see citing works
Stange, A., Mannigel, I., Peters, K., Heinkelein, M., Stanke, N., Cartellieri, M., Göttlinger, H., Rethwilm, A., Zentgraf, H., & Lindemann, D. (2005) · Journal of Virology · doi:10.1128/jvi.79.9.5466-5476.2005 · Cited by 55 · see citing works
Primate foamy virus Pol proteins are imported into the nucleus
Imrich, H., Heinkelein, M., Herchenröder, O., & Rethwilm, A. (2000) · Journal of General Virology · doi:10.1099/0022-1317-81-12-2941 · Cited by 52 · see citing works
Intracellular Targeting of Gag Proteins of theDrosophilaTelomeric Retrotransposons
Rashkova, S., Athanasiadis, A., & Pardue, M. L. (2003) · Journal of Virology · doi:10.1128/jvi.77.11.6376-6384.2003 · Cited by 48 · see citing works
Biphasic DNA Synthesis in Spumaviruses
Delelis, O., Saı̈b, A., & Sonigo, P. (2003) · Journal of Virology · doi:10.1128/jvi.77.14.8141-8146.2003 · Cited by 48 · see citing works
Self-citationCentrosomal Latency of Incoming Foamy Viruses in Resting Cells
Lehmann‐Che, J., Renault, N., Giron, M.-L., Roingeard, P., Clave, E., Tobaly-Tapiero, J., Bittoun, P., Toubert, A., de Thé, H., & Saı̈b, A. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030074 · Cited by 45 · see citing works
Self-citationMultiple Integrations of Human Foamy Virus in Persistently Infected Human Erythroleukemia Cells
Meiering, C. D., Comstock, K. E., & Linial, M. L. (2000) · Journal of Virology · doi:10.1128/jvi.74.4.1718-1726.2000 · Cited by 44 · see citing works
Role of the C Terminus of Foamy Virus Gag in RNA Packaging and Pol Expression
Stenbak, C. R., & Linial, M. L. (2004) · Journal of Virology · doi:10.1128/jvi.78.17.9423-9430.2004 · Cited by 43 · see citing works
Identification of Domains in Gag Important for Prototypic Foamy Virus Egress
Patton, G., Morris, S. A., Chung, W., Bieniasz, P. D., & McClure, M. O. (2005) · Journal of Virology · doi:10.1128/jvi.79.10.6392-6399.2005 · Cited by 42 · see citing works
Genetic requirements for the episomal maintenance of oncogenic herpesvirus genomes
Collins, C. M., & Medveczky, P. G. (2002) · Advances in cancer research · doi:10.1016/s0065-230x(02)84005-2 · Cited by 41 · see citing works
Yuan, B., Fassati, A., Yueh, A., & Goff, S. P. (2002) · Journal of Virology · doi:10.1128/jvi.76.21.10801-10810.2002 · Cited by 40 · see citing works
Human Foamy Virus Capsid Formation Requires an Interaction Domain in the N Terminus of Gag
Tobaly-Tapiero, J., Bittoun, P., Giron, M.-L., Neves, M., Koken, M. H. M., Saı̈b, A., & de Thé, H. (2001) · Journal of Virology · doi:10.1128/jvi.75.9.4367-4375.2001 · Cited by 39 · see citing works
Self-citationExpression and maturation of human foamy virus Gag precursor polypeptides
Giron, M.-L., Colas, S., Wybier, J., Rozain, F., & Emanoil‐Ravier, R. (1997) · Journal of Virology · doi:10.1128/jvi.71.2.1635-1639.1997 · Cited by 37 · see citing works
Self-citationProtease-Dependent Uncoating of a Complex Retrovirus
Lehmann‐Che, J., Giron, M.-L., Delelis, O., Löchelt, M., Bittoun, P., Tobaly-Tapiero, J., de Thé, H., & Saı̈b, A. (2005) · Journal of Virology · doi:10.1128/jvi.79.14.9244-9253.2005 · Cited by 37 · see citing works
Self-citationLife, R. B., Lee, E.-G., Eastman, S. W., & Linial, M. L. (2008) · Journal of Virology · doi:10.1128/jvi.00503-08 · Cited by 34 · see citing works
N-Terminal Gag Domain Required for Foamy Virus Particle Assembly and Export
Cartellieri, M., Herchenröder, O., Rudolph, W. W., Heinkelein, M., Lindemann, D., Zentgraf, H., & Rethwilm, A. (2005) · Journal of Virology · doi:10.1128/jvi.79.19.12464-12476.2005 · Cited by 21 · see citing works
Jin, S., Chen, C.-P., & Montelaro, R. (2005) · Journal of Virology · doi:10.1128/jvi.79.14.8793-8801.2005 · Cited by 16 · see citing works
Quantification of HFV-Integrated DNA in Human Cells by Alu-LTR Real-Time PCR
Delelis, O., Brussel, A., & Sonigo, P. (2005) · Humana Press eBooks · doi:10.1385/1-59259-907-9:155 · Cited by 11 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [24]24. Life RB, Lee EG, Eastman SW, Linial ML. Mutations in the aminoterminus of foamy virus Gag disrupt morphology and infectivity, but not targeting of assembly. J Virol 2008;82:6109-6119.
Cited by
Sorted by citations
Integration site selection by retroviruses and transposable elements in eukaryotes
Sultana, T., Zamborlini, A., Cristofari, G., & Lesage, P. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.7 · Cited by 275 · see citing works
Functional and structural characterization of the integrase from the prototype foamy virus
Valkov, E., Gupta, S. S., Hare, S., Helander, A., Roversi, P., McClure, M., & Cherepanov, P. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn938 · Cited by 130 · see citing works
Structure and function of retroviral integrase
Maertens, G. N., Engelman, A. N., & Cherepanov, P. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00586-9 · Cited by 124 · see citing works
Foamy Virus Biology and Its Application for Vector Development
Lindemann, D., & Rethwilm, A. (2011) · Viruses · doi:10.3390/v3050561 · Cited by 97 · see citing works
Interactions between Retroviruses and the Host Cell Genome
Poletti, V., & Mavilio, F. (2017) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2017.10.001 · Cited by 81 · see citing works
Retroviral integration site selection
Desfarges, S., & Ciuffi, A. (2010) · Viruses · doi:10.3390/v2010111 · Cited by 78 · see citing works
Garbitt, R. A., Kenney, S. P., & Parent, L. J. (2009) · Journal of Virology · doi:10.1128/jvi.00101-09 · Cited by 68 · see citing works
LEDGF/p75 Proteins with Alternative Chromatin Tethers Are Functional HIV-1 Cofactors
Meehan, A. M., Saenz, D. T., Morrison, J. H., Garcia-Rivera, J. A., Peretz, M., Llano, M., & Poeschla, E. M. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000522 · Cited by 67 · see citing works
Stirnnagel, K., Lüftenegger, D., Stange, A., Swiersy, A., Müllers, E., Reh, J., Stanke, N., Große, A., Chiantia, S., Keller, H., et al. (2010) · Retrovirology · doi:10.1186/1742-4690-7-45 · Cited by 64 · see citing works
Molecular biology of foamy viruses
Rethwilm, A. (2010) · Medical Microbiology and Immunology · doi:10.1007/s00430-010-0158-x · Cited by 64 · see citing works
Viral Integration and Consequences on Host Gene Expression
Desfarges, S., & Ciuffi, A. (2012) · Springer eBooks · doi:10.1007/978-94-007-4899-6_7 · Cited by 62 · see citing works
Müllers, E., Uhlig, T., Stirnnagel, K., Fiebig, U., Zentgraf, H., & Lindemann, D. (2010) · Journal of Virology · doi:10.1128/jvi.01731-10 · Cited by 58 · see citing works
Prototype Foamy Virus Gag Nuclear Localization: a Novel Pathway among Retroviruses
Müllers, E., Stirnnagel, K., Kaulfuss, S., & Lindemann, D. (2011) · Journal of Virology · doi:10.1128/jvi.00663-11 · Cited by 54 · see citing works
HIV trafficking in host cells: motors wanted!
Gaudin, R., de Alencar, B. C., Arhel, N. J., & Benaroch, P. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.09.004 · Cited by 52 · see citing works
Structural basis for spumavirus GAG tethering to chromatin
Lesbats, P., Serrao, E., Maskell, D. P., Pye, V. E., O’Reilly, N., Lindemann, D., Engelman, A. N., & Cherepanov, P. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1621159114 · Cited by 51 · see citing works
Intracellular partitioning of cell organelles and extraneous nanoparticles during mitosis
Symens, N., Soenen, S. J., Rejman, J., Braeckmans, K., Smedt, S. C. D., & Remaut, K. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.11.012 · Cited by 51 · see citing works
Virophages and retrotransposons colonize the genomes of a heterotrophic flagellate
Hackl, T., Duponchel, S., Barenhoff, K., Weinmann, A., & Fischer, M. (2021) · eLife · doi:10.7554/elife.72674 · Cited by 51 · see citing works
Schneider, W. M., Brzezinski, J. D., Aiyer, S., Malani, N., Gyuricza, M., Bushman, F. D., & Roth, M. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221736110 · Cited by 49 · see citing works
The Foamy Virus Gag Proteins: What Makes Them Different?
Müllers, E. (2013) · Viruses · doi:10.3390/v5041023 · Cited by 46 · see citing works
Mücke, K., Paulus, C., Bernhardt, K., Gerrer, K., Schön, K., Fink, A., Sauer, E., Nitzsche, A., Harwardt, T., Kieninger, B., et al. (2013) · Journal of Virology · doi:10.1128/jvi.02606-13 · Cited by 43 · see citing works
Nuclear Trafficking of Retroviral RNAs and Gag Proteins during Late Steps of Replication
Stake, M. S., Bann, D. V., Maldonado, R. J. K., & Parent, L. J. (2013) · Viruses · doi:10.3390/v5112767 · Cited by 36 · see citing works
Maldonado, R. J. K., & Parent, L. J. (2016) · Viruses · doi:10.3390/v8090257 · Cited by 36 · see citing works
Strategies for Targeting Retroviral Integration for Safer Gene Therapy: Advances and Challenges
Yoder, K. E., Rabe, A. J., Fishel, R. A., & Larue, R. C. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.662331 · Cited by 34 · see citing works
Wight, D. J., Boucherit, V., Nader, M., Allen, D. J., Taylor, I. A., & Bishop, K. N. (2012) · Retrovirology · doi:10.1186/1742-4690-9-83 · Cited by 32 · see citing works
Foamy-like endogenous retroviruses are extensive and abundant in teleosts
Ruboyianes, R. S., & Worobey, M. (2016) · Virus Evolution · doi:10.1093/ve/vew032 · Cited by 31 · see citing works
Visualizing Association of the Retroviral Gag Protein with Unspliced Viral RNA in the Nucleus
Maldonado, R. J. K., Rice, B. L., Chen, E. C., Tuffy, K. M., Chiari, E. F., Fahrbach, K. M., Hope, T. J., & Parent, L. J. (2020) · mBio · doi:10.1128/mbio.00524-20 · Cited by 29 · see citing works
Wanaguru, M., Barry, D. J., Benton, D. J., O’Reilly, N. J., & Bishop, K. N. (2018) · PLOS Pathogens · doi:10.1371/journal.ppat.1007117 · Cited by 27 · see citing works
Feline Immunodeficiency Virus Gag Is a Nuclear Shuttling Protein
Kemler, I., Saenz, D. T., & Poeschla, E. M. (2012) · Journal of Virology · doi:10.1128/jvi.00692-12 · Cited by 27 · see citing works
HIV-1 Gag Forms Ribonucleoprotein Complexes with Unspliced Viral RNA at Transcription Sites
Tuffy, K. M., Maldonado, R. J. K., Chang, J. T., Rosenfeld, P., Cochrane, A., & Parent, L. J. (2020) · Viruses · doi:10.3390/v12111281 · Cited by 27 · see citing works
Hamann, M. V., Müllers, E., Reh, J., Stanke, N., Effantin, G., Weissenhorn, W., & Lindemann, D. (2014) · Retrovirology · doi:10.1186/s12977-014-0087-7 · Cited by 25 · see citing works
Renault, N., Tobaly-Tapiero, J., Paris, J., Giron, M.-L., Coiffic, A., Roingeard, P., & Saı̈b, A. (2011) · Retrovirology · doi:10.1186/1742-4690-8-6 · Cited by 24 · see citing works
Self-citationViral Genome Tethering to Host Cell Chromatin: Cause and Consequences
Aydin, I., & Schelhaas, M. (2016) · Traffic · doi:10.1111/tra.12378 · Cited by 24 · see citing works
Vranckx, L. S., Demeulemeester, J., Debyser, Z., & Gijsbers, R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164167 · Cited by 24 · see citing works
Stirnnagel, K., Schupp, D., Dupont, A., Kudryavtsev, V., Reh, J., Müllers, E., Lamb, D. C., & Lindemann, D. (2012) · Retrovirology · doi:10.1186/1742-4690-9-71 · Cited by 23 · see citing works
Chromatin tethering and retroviral integration: Recent discoveries and parallels with DNA viruses
Meehan, A. M., & Poeschla, E. M. (2009) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2009.10.001 · Cited by 23 · see citing works
HIVToolbox, an Integrated Web Application for Investigating HIV
Sargeant, D. P., Deverasetty, S., Luo, Y., Baleta, A. V., Zobrist, S., Rathnayake, V. R., Russo, J. C., Vyas, J., Muesing, M. A., & Schiller, M. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020122 · Cited by 21 · see citing works
Lo, Y.-T., Tian, T., Nadeau, P. E., Park, J., & Mergia, A. (2009) · Journal of Virology · doi:10.1128/jvi.02435-09 · Cited by 20 · see citing works
Early Reverse Transcription Is Essential for Productive Foamy Virus Infection
Zamborlini, A., Renault, N., Saı̈b, A., & Delelis, O. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011023 · Cited by 19 · see citing works
Self-citationEarly Events in Foamy Virus—Host Interaction and Intracellular Trafficking
Berka, U., Hamann, M. V., & Lindemann, D. (2013) · Viruses · doi:10.3390/v5041055 · Cited by 19 · see citing works
Retroviral integrase: Structure, mechanism, and inhibition
Passos, D. O., Li, M., Craigie, R., & Lyumkis, D. (2021) · The Enzymes · doi:10.1016/bs.enz.2021.06.007 · Cited by 18 · see citing works
Structure of a Spumaretrovirus Gag Central Domain Reveals an Ancient Retroviral Capsid
Ball, N. J., Nicastro, G., Dutta, M., Pollard, D. J., Goldstone, D. C., Sanz-Ramos, M., Ramos, A., Müllers, E., Stirnnagel, K., Stanke, N., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005981 · Cited by 18 · see citing works
The First Co-Opted Endogenous Foamy Viruses and the Evolutionary History of Reptilian Foamy Viruses
Aiewsakun, P., Peter Simmonds, K., & Katzourakis, A. (2019) · Viruses · doi:10.3390/v11070641 · Cited by 18 · see citing works
Retargeted Foamy Virus Vectors Integrate Less Frequently Near Proto-oncogenes
Hocum, J. D., Linde, I., Rae, D. T., Collins, C. P., Matern, L. K., & Trobridge, G. D. (2016) · Scientific Reports · doi:10.1038/srep36610 · Cited by 17 · see citing works
Centrophilic Retrotransposons of Plant Genomes
Bousios, A., Kakutani, T., & Henderson, I. R. (2025) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-083123-082220 · Cited by 16 · see citing works
Stefanov, Y. E., Salenko, V. B., & Glukhov, I. (2012) · Mobile Genetic Elements · doi:10.4161/mge.19234 · Cited by 16 · see citing works
Basic Residues in the Foamy Virus Gag Protein
Matthes, D., Wiktorowicz, T., Zahn, J., Bodem, J., Stanke, N., Lindemann, D., & Rethwilm, A. (2011) · Journal of Virology · doi:10.1128/jvi.01906-10 · Cited by 15 · see citing works
Foamy Virus Protein—Nucleic Acid Interactions during Particle Morphogenesis
Hamann, M. V., & Lindemann, D. (2016) · Viruses · doi:10.3390/v8090243 · Cited by 15 · see citing works
Foamy Viruses, Bet, and APOBEC3 Restriction
Vasudevan, A. A. J., Becker, D., Luedde, T., Gohlke, H., & Münk, C. (2021) · Viruses · doi:10.3390/v13030504 · Cited by 14 · see citing works
Chromosomal tethering and proviral integration.
Delelis, O., Zamborlini, A., Thierry, S., & Saı̈b, A. (2010) · Biochimica et Biophysica Acta · doi:10.1016/j.bbagrm.2009.08.005 · Cited by 14 · see citing works
Self-citationEvidence for Tethering of Human Cytomegalovirus Genomes to Host Chromosomes
Mauch-Mücke, K., Schön, K., Paulus, C., & Nevels, M. M. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.577428 · Cited by 13 · see citing works
Evidence for the in vivo safety of insulated foamy viral vectors
Browning, D. L., Everson, E. M., Leap, D. J., Hocum, J. D., Wang, H., Stamatoyannopoulos, G., & Trobridge, G. D. (2016) · Gene Therapy · doi:10.1038/gt.2016.88 · Cited by 13 · see citing works
Virus–Host Interactions in Retrovirus Integration
Engelman, A. N., & Maertens, G. N. (2018) · Retrovirus-Cell Interactions · doi:10.1016/b978-0-12-811185-7.00004-2 · Cited by 12 · see citing works
Paris, J., Tobaly-Tapiero, J., Giron, M.-L., Burlaud‐Gaillard, J., Buseyne, F., Roingeard, P., Lesage, P., Zamborlini, A., & Saı̈b, A. (2018) · Retrovirology · doi:10.1186/s12977-018-0428-z · Cited by 12 · see citing works
Self-citationInterplay between the alpharetroviral Gag protein and SR proteins SF2 and SC35 in the nucleus
Rice, B. L., Maldonado, R. J. K., Stake, M. S., Lochmann, T. L., & Parent, L. J. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00925 · Cited by 11 · see citing works
Zurnic, I., Hütter, S., Rzeha, U., Stanke, N., Reh, J., Müllers, E., Hamann, M. V., Kern, T., Gerresheim, G. K., Lindel, F., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005860 · Cited by 11 · see citing works
Targeting the Nucleosome Acidic Patch by Viral Proteins: Two Birds with One Stone?
Lagadec, F., Parissi, V., & Lesbats, P. (2022) · mBio · doi:10.1128/mbio.01733-21 · Cited by 9 · see citing works
Wei, G., Kehl, T., Bao, Q., Benner, A., Lei-Rossmann, J., & Löchelt, M. (2018) · Virology · doi:10.1016/j.virol.2018.08.007 · Cited by 9 · see citing works
The Unique, the Known, and the Unknown of Spumaretrovirus Assembly
Lindemann, D., Hütter, S., Wei, G., & Löchelt, M. (2021) · Viruses · doi:10.3390/v13010105 · Cited by 9 · see citing works
Repression of the Chromatin-Tethering Domain of Murine Leukemia Virus p12
Brzezinski, J. D., Modi, A., Liu, M., & Roth, M. J. (2016) · Journal of Virology · doi:10.1128/jvi.01084-16 · Cited by 8 · see citing works
Brief Histories of Retroviral Integration Research and Associated International Conferences
Grandgenett, D. P., & Engelman, A. (2024) · Viruses · doi:10.3390/v16040604 · Cited by 7 · see citing works
Hossain, A., Ali, M. K., & Shin, C. (2014) · Molecules and Cells · doi:10.14348/molcells.2014.2331 · Cited by 6 · see citing works
Comparative analysis of retroviral Gag-host cell interactions: focus on the nuclear interactome
Lambert, G. S., Rice, B. L., Maldonado, R. J. K., Chang, J., & Parent, L. J. (2024) · Retrovirology · doi:10.1186/s12977-024-00645-y · Cited by 5 · see citing works
Dustin, T., & Grant, D. (2013) · InTech eBooks · doi:10.5772/52530 · Cited by 4 · see citing works
Structural and Functional Insights into Foamy Viral Integrase
Hossain, M. A., Ali, M. K., & Shin, C. (2013) · Viruses · doi:10.3390/v5071850 · Cited by 4 · see citing works
The role of chromatin in retroviral preintegration complex function
Sapp, N., Prakash, P., Chakraborty, R., Balasubramaniam, M., & Dash, C. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110440 · Cited by 3 · see citing works
Viral peptide conjugates for metal-warhead delivery to chromatin
Batchelor, L. K., Falco, L. D., Dyson, P. J., & Davey, C. A. (2024) · RSC Advances · doi:10.1039/d4ra01617c · Cited by 3 · see citing works
Foamy Virus Integrase in Development of Viral Vector for Gene Therapy
Kim, J., Lee, G., & Shin, C. (2020) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2003.03046 · Cited by 3 · see citing works
Murine leukemia virus p12 functions include hitchhiking into the nucleus
Rein, A. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307399110 · Cited by 3 · see citing works
Chen, E. C., & Parent, L. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811185-7.00008-x · Cited by 2 · see citing works
Investigating the Intercellular Spreading Properties of the Foamy Virus Gag Protein
Tobaly-Tapiero, J., Zamborlini, A., Bittoun, P., & Saı̈b, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031108 · Cited by 1 · see citing works
Self-citationLagadec, F., Singh, P. K., Calmels, C., Lapaillerie, D., Lindemann, D., Parissi, V., Cherepanov, P., Engelman, A., & Lesbats, P. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf449 · Cited by 1 · see citing works
[Nuclear export of retroviral messenger RNA].
Renault, N., Coiffic, A., & Saı̈b, A. (2008) · PubMed · doi:10.1684/12-6.2021.12570 · Cited by 1 · see citing works
Self-citationFoamy-like Endogenous Retroviruses Are Abundant and Extensive In Teleosts
Ruboyianes, R. S. (2015) · UA Campus Repository (The University of Arizona)
Foamy virus vector integration and application in gene therapy
Sweeney, N. P. (2015) · Spiral (Imperial College London) · doi:10.25560/50704
- Authors
- Tobaly‐Tapiero, J., Bittoun, P., Lehmann‐Che, J., Delelis, O., Giron, M., De Thé, H., & Saïb, A.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- École Normale Supérieure Paris-Saclay (FR)
- Venue
- Traffic
- Publisher
- Wiley
- Published
- 2008-09-15
- Volume
- 9
- Issue
- 10
- Pages
- 1717-1727
- ISSN
- 1398-9219 (ISSN-L)
- 1600-0854
- OpenAlex
- W2011996850
- Cited by
- 74
- References
- 52
- Citations by year
- 2025: 3 · 2024: 3 · 2022: 1 · 2021: 6 · 2020: 4 · 2019: 1 · 2018: 5 · 2017: 3 · 2016: 10 · 2015: 3 · 2014: 2 · 2013: 9 · 2012: 6
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Traffic (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- Gag protein, chromatin tethering, preintegration complex, proviral integration, retroviral replication
- MeSH terms
- Animals, Binding Sites, Cell Line, Chlorocebus aethiops, Chromatin, DNA, Viral, Electrophoresis, Polyacrylamide Gel, Cricetinae, Histones, Microscopy, Fluorescence, Mutation, Protein Binding, Recombinant Fusion Proteins, Transfection, Virus Replication, Gene Products, gag, Spumavirus, Virus Integration, Green Fluorescent Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review