The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Everolimus Plus Reduced‐Exposure CsA versus Mycophenolic Acid Plus Standard‐Exposure CsA in Renal‐Transplant Recipients
Open accessAbstract
Everolimus allows calcineurin-inhibitor reduction without loss of efficacy and may improve renal-transplant outcomes. In a 24-month, open-label study, 833 de novo renal-transplant recipients were randomized to everolimus 1.5 or 3.0 mg/day (target troughs 3-8 and 6-12 ng/mL, respectively) with reduced-exposure CsA, or mycophenolic acid (MPA) 1.44 g/day plus standard-exposure CsA. Patients received basiliximab +/- corticosteroids. The primary endpoint was composite efficacy failure (treated biopsy-proven acute rejection, graft loss, death or loss to follow-up) and the main safety endpoint was renal function (estimated glomerular filtration rate [eGFR], by Modification of Diet in Renal Disease [MDRD]) at Month 12 (last-observation-carried-forward analyses). Month 12 efficacy failure rates were noninferior in the everolimus 1.5 mg (25.3%) and 3.0 mg (21.9%) versus MPA (24.2%) groups. Mean eGFR at Month 12 was noninferior in the everolimus groups versus the MPA group (54.6 and 51.3 vs 52.2 mL/min/1.73 m(2) in the everolimus 1.5 mg, 3.0 mg and MPA groups, respectively; 95% confidence intervals for everolimus 1.5 mg and 3.0 mg vs MPA: -1.7, 6.4 and -5.0, 3.2, respectively). The overall incidence of adverse events was comparable between groups. The use of everolimus with progressive reduction in CsA exposure, up to 60% at 1 year, resulted in similar efficacy and renal function compared with standard-exposure CsA plus MPA.
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Cites
A sharper Bonferroni procedure for multiple tests of significance
HOCHBERG, Y. (1988) · Biometrika · doi:10.1093/biomet/75.4.800 · Cited by 4,829
Coresh, J., Astor, B. C., Greene, T., Eknoyan, G., & Levey, A. S. (2003) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2003.50007 · Cited by 2,768
Racusen, L. C., Colvin, R. B., Solez, K., Mihatsch, M. J., Halloran, P. F., Campbell, P. M., Cecka, M. J., Cosyns, J., Demetris, A. J., Fishbein, M. C., et al. (2003) · American Journal of Transplantation · doi:10.1034/j.1600-6143.2003.00072.x · Cited by 1,060
Post-transplant renal function in the first year predicts long-term kidney transplant survival
Hariharan, S., Mcbride, M. A., Cherikh, W. S., Tolleris, C. B., Bresnahan, B. A., & Johnson, C. P. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00424.x · Cited by 748
SDZ RAD, A NEW RAPAMYCIN DERIVATIVE: Pharmacological Properties In Vitro and In Vivo
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PREDICTING GLOMERULAR FILTRATION RATE AFTER KIDNEY TRANSPLANTATION
Nankivell, B. J., Gruenewald, S. M., Allen, R. D. M., & Chapman, J. R. (1995) · Transplantation · doi:10.1097/00007890-199506270-00007 · Cited by 292
Vitko, S., Tedesco, H., Eris, J., Pascual, J., Whelchel, J., Magee, J. C., Campbell, S., Civati, G., Bourbigot, B., Filho, G. A., et al. (2004) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2004.00389.x · Cited by 254
Valente, J. F., Hricik, D., Weigel, K., Seaman, D., Knauss, T., Siegel, C. T., Bodziak, K., & Schulak, J. A. (2003) · American Journal of Transplantation · doi:10.1034/j.1600-6143.2003.00185.x · Cited by 241
Lorber, M. I., Mulgaonkar, S., Butt, K. M. H., Elkhammas, E., Mendez, R., Rajagopalan, P. R., Kahan, B., Sollinger, H., Li, Y., Cretin, N., et al. (2005) · Transplantation · doi:10.1097/01.tp.0000164352.65613.24 · Cited by 231
Vítko, Š., Margreiter, R., Weimar, W., Dantal, J., Kuypers, D., Winkler, M., Øyen, O., Viljoen, H. G., Filiptsev, P., Sadek, S., et al. (2005) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2005.01063.x · Cited by 216
Cited by
Nelson, J., Alvey, N., Bowman, L., Schulte, J., Segovia, M. C., McDermott, J., Te, H. S., Kapila, N., Levine, D. J., Gottlieb, R. L., et al. (2022) · Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.2716 · Cited by 130
Metadata
- Authors
- Silva Jr., H. T., Cibrik, D., Johnston, T., Lackova, E., Mange, K., Panis, C., Walker, R., Wang, Z., Zibari, G., & Kim, Y. S.
- Venue
- American Journal of Transplantation
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 10
- Issue
- 6
- Pages
- 1401-1413
- ISSN
- 1600-6135 (ISSN-L)
- OpenAlex
- W1600996638
- Cited by
- 269
- References
- 15
- FWCI
- 16.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Everolimus Plus Reduced‐Exposure CsA versus Mycophenolic Acid Plus Standard‐Exposure CsA in Renal‐Transplant Recipients. https://app.cochat.ai/papers/10.1111/j.1600-6143.2010.03129.x
- The paper
- Silva Jr., H. T., Cibrik, D., Johnston, T., Lackova, E., Mange, K., Panis, C., Walker, R., Wang, Z., Zibari, G., & Kim, Y. S. (2010). Everolimus Plus Reduced‐Exposure CsA versus Mycophenolic Acid Plus Standard‐Exposure CsA in Renal‐Transplant Recipients. American Journal of Transplantation. https://doi.org/10.1111/j.1600-6143.2010.03129.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
