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Cited by 428

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

NK Cell Transcripts and NK Cells in Kidney Biopsies from Patients with Donor-Specific Antibodies: Evidence for NK Cell Involvement in Antibody-Mediated Rejection

Open access
Hidalgo, L.G, Sis, B., Sellares, J., Campbell, P.M, Mengel, M., Einecke, G., Chang, J., Halloran, P.F·2010·American Journal of Transplantation
DOI 10.1111/j.1600-6143.2010.03201.x
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Abstract

To explore the mechanisms of antibody-mediated rejection (ABMR) in kidney transplants, we studied the transcripts expressed in clinically indicated biopsies from patients with donor-specific antibody (DSA). Comparison of biopsies from DSA-positive versus DSA-negative patients revealed 132 differentially expressed transcripts: all were associated with class II DSA but none with class I DSA. Many transcripts were expressed in DSA-positive ABMR but were also expressed in T-cell-mediated rejection (TCMR), reflecting shared molecular features. Removal of shared transcripts created 23 DSA selective transcripts (DSASTs). Some DSASTs (6/23) showed selective high expression in NK cells, whereas others (8/23) were expressed in endothelium or in endothelium plus other cell types (7/23). Of 145 biopsies ranked by DSAST expression, the 25 with highest DSAST expression primarily consisted of ABMR (22/25, 88%), either C4d-positive or C4d-negative. By immunostaining, CD56+ and CD68+ cells in peritubular capillaries, but not CD3+ cells, were increased in ABMR compared to TCMR, compatible with a role for NK cells, as well as macrophages, as effectors in endothelial injury during ABMR. Thus, the strategy of using DSASTs in the biopsy to identify mechanism-related transcripts in biopsies from patients with clinical phenotypes indicates the selective involvement of NK cells in ABMR.

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Metadata

Authors
Hidalgo, L. G., Sis, B., Sellares, J., Campbell, P. M., Mengel, M., Einecke, G., Chang, J., & Halloran, P. F.
Venue
American Journal of Transplantation
Publisher
Elsevier BV
Published
2010-08
Volume
10
Issue
8
Pages
1812-1822
ISSN
1600-6135 (ISSN-L)
DOI
10.1111/j.1600-6143.2010.03201.x
OpenAlex
W1496154285
Cited by
428
References
32
FWCI
14.72
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: NK Cell Transcripts and NK Cells in Kidney Biopsies from Patients with Donor-Specific Antibodies: Evidence for NK Cell Involvement in Antibody-Mediated Rejection. https://app.cochat.ai/papers/10.1111/j.1600-6143.2010.03201.x
The paper
Hidalgo, L. G., Sis, B., Sellares, J., Campbell, P. M., Mengel, M., Einecke, G., Chang, J., & Halloran, P. F. (2010). NK Cell Transcripts and NK Cells in Kidney Biopsies from Patients with Donor-Specific Antibodies: Evidence for NK Cell Involvement in Antibody-Mediated Rejection. American Journal of Transplantation. https://doi.org/10.1111/j.1600-6143.2010.03201.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.