Changes in neurocognitive functioning following lung transplantation
Open accessAbstract
Although neurocognitive impairment is relatively common among patients with advanced lung disease, little is known regarding changes in neurocognition following lung transplantation. We therefore administered 10 tests of neurocognitive functioning before and 6 months following lung transplantation and sought to identify predictors of change. Among the 49 study participants, native diseases included chronic obstructive pulmonary disease (n = 22), cystic fibrosis (n = 12), nonfibrotic diseases (n = 11) and other (n = 4). Although composite measures of executive function and verbal memory scores were generally within normal limits both before and after lung transplantation, verbal memory performance was slightly better posttransplant compared to baseline (p < 0.0001). Executive function scores improved in younger patients but worsened in older patients (p = 0.03). A minority subset of patients (29%) exhibited significant cognitive decline (i.e. >1 standard deviations on at least 20% of tests) from baseline to posttransplant. Patients who declined were older (p < 0.004) and tended to be less educated (p = 0.07). Lung transplantation, like cardiac revascularization procedures, appears to be associated with cognitive decline in a subset of older patients, which could impact daily functioning posttransplant.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Other forms of cognitive dysfunction among individuals with advanced pulmonary disease may be amplified by hypoxemia or polypharmacy, and may improve post-transplant in some cases.
“Other forms of cognitive dysfunction among individuals with advanced pulmonary disease may be amplified by hypoxemia or polypharmacy, and may improve post-transplant in some cases.(94–99)”
From Consensus document for the selection of lung transplant candidates: An update from the International Society for Heart and Lung Transplantation. (2021) · cites this paper as [99]
The introductory passage (page unavailable) identifies hypoxemia as a possible contributor to neurocognitive impairment in end-stage lung disease. The Conclusions (page unavailable) report that neurocognitive functioning improved in some cases after transplantation. The paper discusses medication side effects as a possible contributor to post-transplant decline, but does not identify polypharmacy as a contributor to cognitive dysfunction in advanced pulmonary disease. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(1970) · Cited by 24,983 · see citing works
STAI manual for the State-trait anxiety inventory
Cd, S. (1970) · Medical Entomology and Zoology · Cited by 2,433 · see citing works
Benton, A. (1994) · Annual Review of Psychology · doi:10.1146/annurev.psych.45.1.1 · Cited by 2,298 · see citing works
Reynolds, C. R., & Powel, J. (1988) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/3.4.397 · Cited by 2,115 · see citing works
Longitudinal Assessment of Neurocognitive Function after Coronary-Artery Bypass Surgery
Newman, M. F., Kirchner, J., Phillips‐Bute, B., Gaver, V., Grocott, H. P., Jones, R. H., Mark, D. B., Reves, J. G., & Blumenthal, J. A. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102083440601 · Cited by 1,959 · see citing works
Self-citationStroop Color and Word Test: Manual for Clinical and Experimental Uses.
Golden, C. J., Golden, C. J., & Golden, C. (1978) · NSUWorks (Nova Southeastern University) · Cited by 1,814 · see citing works
WAIS-R manual : Wechsler adult intelligence scale-revised
Wechsler, D. (1981) · Medical Entomology and Zoology · Cited by 1,575 · see citing works
International guidelines for the selection of lung transplant candidates
Maurer, J. R., Frost, A. E., Estenne, M., Higenbottam, T., & Glanville, A. R. (1998) · Transplantation · doi:10.1097/00007890-199810150-00033 · Cited by 562 · see citing works
Dodd, J. W., Getov, S. V., & Jones, P. W. (2010) · European Respiratory Journal · doi:10.1183/09031936.00125109 · Cited by 426 · see citing works
Defining neuropsychological dysfunction after coronary artery bypass grafting
Mahanna, E. P., Blumenthal, J. A., White, W. D., et al. (1996) · The Annals of Thoracic Surgery · doi:10.1016/0003-4975(95)01095-5 · Cited by 261 · see citing works
Self-citationShahid, A., Wilkinson, K., Marcu, S., & Shapiro, C. M. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9893-4_8 · Cited by 214 · see citing works
Maurer, J., Frost, A., Estenne, M., Higenbottam, T., & Glanville, A. R. (1998) · PubMed · Cited by 187 · see citing works
Drawing Impairment Predicts Mortality in Severe COPD
Incalzi, R. A., Corsonello, A., Pedone, C., Trojano, L., Domenico, A., Spada, A., Izzo, O., & Rengo, F. (2006) · CHEST Journal · doi:10.1378/chest.130.6.1687 · Cited by 138 · see citing works
Tacrolimus-Associated Posterior Reversible Encephalopathy Syndrome after Solid Organ Transplantation
Wu, Q., Marescaux, C., Wolff, V., Jeung, M., Kessler, R., Lauer, V., & Chen, Y. (2010) · European Neurology · doi:10.1159/000319032 · Cited by 132 · see citing works
General Overview of Lung Transplantation and Review of Organ Allocation
Orens, J. B., & Garrity, E. R. (2009) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200807-072go · Cited by 119 · see citing works
Drawing Impairment Predicts Mortality in Severe COPD.
Incalzi, R. A., Corsonello, A., Pedone, C., Trojano, L., Acanfora, D., Spada, A., Izzo, O., & Rengo, F. (2007) · Cardiopulmonary Physical Therapy Journal · doi:10.1097/01823246-200718010-00008 · Cited by 108 · see citing works
Psychological and cognitive status before and after heart transplantation
Deshields, T. L., McDonough, E., Mannen, R. K., & Miller, L. W. (1996) · General Hospital Psychiatry · doi:10.1016/s0163-8343(96)00078-3 · Cited by 87 · see citing works
Telephone-based coping skills training for patients awaiting lung transplantation
Blumenthal, J. A., Babyak, M. A., Carney, R. M., Keefe, F. J., Davis, R. D., LaCaille, R. A., Parekh, P. I., Freedland, K. E., Trulock, E., & Palmer, S. M. (2006) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.74.3.535 · Cited by 82 · see citing works
Continuous cognitive improvement 1 year following successful kidney transplant
Harciarek, M., Biedunkiewicz, B., Lichodziejewska–Niemierko, M., Dębska-Ślizień, A. M., & Rutkowski, B. (2011) · Kidney International · doi:10.1038/ki.2011.40 · Cited by 78 · see citing works
Gas exchange and exercise capacity affect neurocognitive performance in patients with lung disease
Parekh, P. I., Blumenthal, J. A., Babyak, M. A., LaCaille, R., Rowe, S., Dancel, L., Carney, R. M., Davis, R. D., & Palmer, S. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000160479.99765.18 · Cited by 38 · see citing works
Self-citationInternational guidelines for the selection of lung transplant candidates
Maurer, J., Frost, A., Estenne, M., et al. (1998) · Heart & Lung · doi:10.1016/s0147-9563(98)90033-4 · Cited by 12 · see citing works
Implications of impaired cognition for organ transplant candidacy
Arciniegas, D. B., & Filley, C. M. (1999) · Current Opinion in Organ Transplantation · doi:10.1097/00075200-199906000-00014 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Leard, L. E., Holm, A. M., Valapour, M., Glanville, A. R., Attawar, S., Aversa, M., Campos, S. V., Christon, L. M., Cypel, M., Dellgren, G., et al. (2021) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2021.07.005 · Cited by 821 · see citing works
Self-citationNeurocognitive changes after lung transplantation
Smith, P. J., Rivelli, S., Waters, A., Reynolds, J., Hoyle, A., Flowers, M., Davis, R. D., Palmer, S. M., Mathew, J., Durheim, M., et al. (2014) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201406-232oc · Cited by 60 · see citing works
Self-citation
- Authors
- Hoffman, B. M., Blumenthal, J. A., Carney, R. C., O’Hayer, C. V. F., Freedland, K., Smith, P. J., Babyak, M. A., Davis, R. D., Mathew, J. P., Martinu, T., & Palmer, S.
- Affiliations
- Duke University (US)
- Duke Medical Center (US)
- Washington University in St. Louis (US)
- Corresponding author
- Hoffman, B.M.
- ORCID
- Venue
- American Journal of Transplantation
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 12
- Issue
- 9
- Pages
- 2519-2525
- ISSN
- 1600-6135 (ISSN-L)
- PMC
- PMC3411880
- OpenAlex
- W1874988841
- Cited by
- 38
- References
- 22
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 1
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- American Journal of Transplantation (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Health and Human Services
- Health Resources and Services Administration
- National Heart, Lung, and Blood Institute (R01HL065503, HL 065503-06A1, HL65503-01)
- Topics
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- lung transplantation, neurocognitive function, cognitive decline, executive function, verbal memory, chronic obstructive pulmonary disease, cystic fibrosis, age as predictor, educational attainment, advanced lung disease
- MeSH terms
- Adult, Cognition, Female, Humans, Lung Diseases, Male, Lung Transplantation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
