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THE AETIOLOGY OF OBESITY IN CHILDREN A Study of 101 Twin Pairs
Abstract
Abstract. The aetiology of obesity in children is studied here with the aid of a material consisting of 40 monozygotic and 61 dizygotic twins. The importance of heredity, early nutrition, and environment during preschool age is analysed. Genetic factors, studied by comparison of intra‐pair differences in monozygotic and dizygotic twins, apparently play a decisive role in the origin of obesity. Analysis of the relation between birth weight and later development of subcutaneous fat in different types of twins does not show that intra‐uterine nutrition is of aetiological importance. The comparison at age seven of groups of ordinary siblings and twins of different types does not support the idea that the pre‐school environment is of importance in aetiology. Such influence seems to act mainly as a modifying factor.
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A dominant role of genetic factors in obesity pathogenesis has been demonstrated in studies comparing concordance of body weight among fraternal versus identical twins and in studies of adults adopted as infants compared with their biological and adoptive parents.
“A dominant role of genetic factors in obesity pathogenesis has also been demonstrated in studies comparing the concordance of body weight among fraternal versus identical twins91, for example, as well as studies of adults adopted as infants compared with their biological and adoptive parents77,92.”
From Joint international consensus statement for ending stigma of obesity (2020) · cites this paper as [91]
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Obesity: global epidemiology and pathogenesis
Blüher, M. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0176-8 · Cited by 5,126
Genetic and Environmental Factors in Relative Body Weight and Human Adiposity
Maes, H. H. M., Neale, M. C., & Eaves, L. J. (1997) · Behavior Genetics · doi:10.1023/a:1025635913927 · Cited by 1,515
An Adoption Study of Human Obesity
Stunkard, A. J., Sørensen, T. I. A., Hanis, C., Teasdale, T. W., Chakraborty, R., Schull, W. J., & Schulsinger, F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198601233140401 · Cited by 1,318
Joint international consensus statement for ending stigma of obesity
Rubino, F., Puhl, R. M., Cummings, D. E., Eckel, R. H., Ryan, D. H., Mechanick, J. I., Nadglowski, J., Ramos Salas, X., Schauer, P. R., Twenefour, D., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0803-x · Cited by 1,152
“A dominant role of genetic factors in obesity pathogenesis has also been demonstrated in studies comparing the concordance of body weight among fraternal versus identical twins 91 , for example, as well as studies of adults adopted as infants compared with their biological and adoptive parents 77, 92 .”
Bray, M. S., & Young, M. E. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2006.00277.x · Cited by 213
Metadata
- Authors
- BÖRJESON, M.
- Corresponding author
- BÖRJESON, M.
- Venue
- Acta Paediatrica
- Publisher
- Wiley
- Published
- 1976-05
- Volume
- 65
- Issue
- 3
- Pages
- 279-287
- ISSN
- 0365-1436 (ISSN-L)
- 0803-5253
- 1651-2227
- OpenAlex
- W2043434181
- Cited by
- 144
- References
- 0
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 6 · 2013: 1
- FWCI
- 15.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Paediatrica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- childhood obesity, etiology, monozygotic twins, dizygotic twins, heredity (biology), genetic factors, birth weight, intrauterine nutrition, preschool environment, subcutaneous adipose tissue, modifying factors
- MeSH terms
- Birth Weight, Child, Diseases in Twins, Female, Humans, Male, Maternal-Fetal Exchange, Obesity, Pregnancy, Skinfold Thickness
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