Circadian rhythms in the development of obesity: potential role for the circadian clock within the adipocyte

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326 · see citing works

Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001

Mokdad, A. H., Ford, E. S., Bowman, B. A., Dietz, W. H., Vinicor, F., Bales, V. S., & Marks, J. S. (2003) · JAMA · doi:10.1001/jama.289.1.76 · Cited by 5,866 · see citing works

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1155 · Cited by 3,725 · see citing works

Impact of sleep debt on metabolic and endocrine function

Spiegel, K., Leproult, R., & Van Cauter, E. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01376-8 · Cited by 3,668 · see citing works

Congenital leptin deficiency is associated with severe early-onset obesity in humans

Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936 · see citing works

Molecular Bases for Circadian Clocks

Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900 · see citing works

Obesity and Metabolic Syndrome in Circadian <i>Clock</i> Mutant Mice

Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485 · see citing works

Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus

Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes &amp; Development · doi:10.1101/gad.183500 · Cited by 2,394 · see citing works

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

Clément, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J.-M., et al. (1998) · Nature · doi:10.1038/32911 · Cited by 2,346 · see citing works

The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator

Preitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198 · see citing works

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001 · see citing works

Role of the CLOCK Protein in the Mammalian Circadian Mechanism

Gekakis, N., Staknis, D., Nguyen, H. B., Davis, F. C., Wilsbacher, L. D., King, D. P., Takahashi, J. S., & Weitz, C. J. (1998) · Science · doi:10.1126/science.280.5369.1564 · Cited by 1,997 · see citing works

Resetting central and peripheral circadian oscillators in transgenic rats

Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R.-I., Ueda, M., Block, G. D., Sakaki, Y., Menaker, M., & Tei, H. (2000) · Science · doi:10.1126/science.288.5466.682 · Cited by 1,907 · see citing works

Resetting of circadian time in peripheral tissues by glucocorticoid signaling

Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U. (2000) · Science · doi:10.1126/science.289.5488.2344 · Cited by 1,859 · see citing works

Entrainment of the circadian clock in the liver by feeding

Stokkan, K.-A., Yamazaki, S., Tei, H., Sakaki, Y., & Menaker, M. (2001) · Science · doi:10.1126/science.291.5503.490 · Cited by 1,800 · see citing works

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

Krude, H., Biebermann, H., Luck, W., Horn, R., Brabant, G. E., & Grüters, A. (1998) · Nature Genetics · doi:10.1038/509 · Cited by 1,719 · see citing works

Genetic and Environmental Factors in Relative Body Weight and Human Adiposity

Maes, H. H. M., Neale, M. C., & Eaves, L. J. (1997) · Behavior Genetics · doi:10.1023/a:1025635913927 · Cited by 1,515 · see citing works

An h <i>Per2</i> Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome

Toh, K. L., Jones, C. R., He, Y., Eide, E. J., Hinz, W. A., Virshup, D. M., Ptáček, L. J., & Fu, Y.-H. (2001) · Science · doi:10.1126/science.1057499 · Cited by 1,460 · see citing works

Leptin enters the brain by a saturable system independent of insulin

Banks, W. A., Kastin, A. J., Huang, W., Jaspan, J. B., & Maness, L. M. (1996) · Peptides · doi:10.1016/0196-9781(96)00025-3 · Cited by 1,222 · see citing works

A frameshift mutation in MC4R associated with dominantly inherited human obesity

Yeo, G. S. H., Farooqi, I. S., Aminian, S., Halsall, D. J., Stanhope, R. G., & O'Rahilly, S. (1998) · Nature Genetics · doi:10.1038/2404 · Cited by 1,159 · see citing works

A leptin missense mutation associated with hypogonadism and morbid obesity

Strobel, A., Issad, T., Camoin, L., Ozata, M., & Strosberg, A. D. (1998) · Nature Genetics · doi:10.1038/ng0398-213 · Cited by 1,158 · see citing works

A frameshift mutation in human MC4R is associated with a dominant form of obesity

Vaisse, C., Clément, K., Guy-grand, B., & Froguel, P. (1998) · Nature Genetics · doi:10.1038/2407 · Cited by 1,091 · see citing works

Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors

Rutter, J., Reick, M., Wu, L. C., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1060698 · Cited by 1,059 · see citing works

The Public Health Impact of Obesity

Visscher, T. L. S., & Seidell, J. C. (2001) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.22.1.355 · Cited by 1,025 · see citing works

Elevation of Plasma Cytokines in Disorders of Excessive Daytime Sleepiness: Role of Sleep Disturbance and Obesity

Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Kales, A., Tyson, K., & Chrousos, G. P. (1997) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem.82.5.3950 · Cited by 974 · see citing works

Is there an association between shift work and having a metabolic syndrome? Results from a population based study of 27 485 people

Karlsson, B., Knutsson, A., & Lindahl, B. (2001) · Occupational and Environmental Medicine · doi:10.1136/oem.58.11.747 · Cited by 924 · see citing works

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

Vaisse, C., Clement, K., Durand, E., Hercberg, S., Guy-Grand, B., & Froguel, P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9238 · Cited by 897 · see citing works

Light-Induced Resetting of a Mammalian Circadian Clock Is Associated with Rapid Induction of the Transcript

Shigeyoshi, Y., Taguchi, K., Yamamoto, S., Takekida, S., Yan, L., Tei, H., Moriya, T., Shibata, S., Loros, J. J., Dunlap, J. C., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80494-8 · Cited by 891 · see citing works

A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock

Jin, X., Shearman, L. P., Weaver, D. R., Zylka, M. J., Vries, G. J. D., & Reppert, S. M. (1999) · Cell · doi:10.1016/s0092-8674(00)80959-9 · Cited by 891 · see citing works

The Role of C/EBP Genes in Adipocyte Differentiation*

Darlington, G., Ross, S. E., & Macdougald, O. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.46.30057 · Cited by 807 · see citing works

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

Farooqi, I. S., Yeo, G. S. H., Keogh, J. M., Aminian, S., Jebb, S. A., Butler, G. E., Cheetham, T. D., & O’Rahilly, S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9397 · Cited by 801 · see citing works

The basic-helix–loop–helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors

Hogenesch, J. B., Gu, Y.-Z., Jain, S. R., & Bradfield, C. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.10.5474 · Cited by 781 · see citing works

A Length Polymorphism in the Circadian Clock Gene Per3 is Linked to Delayed Sleep Phase Syndrome and Extreme Diurnal Preference

Archer, S. N., Robilliard, D. L., Skene, D. J., Smits, M. G., Williams, A., Arendt, J., & von Schantz, M. (2003) · SLEEP · doi:10.1093/sleep/26.4.413 · Cited by 734 · see citing works

A CLOCK Polymorphism Associated with Human Diurnal Preference

Katzenberg, D. R., Young, T. B., Finn, L. A., Lin, L., King, D. P., Takahashi, J. S., & Mignot, E. J.-M. (1998) · SLEEP · doi:10.1093/sleep/21.6.569 · Cited by 587 · see citing works

The Molecular Clock Mediates Leptin-Regulated Bone Formation

Fu, L., Patel, M. S., Bradley, A., Wagner, E. F., & Karsenty, G. (2005) · Cell · doi:10.1016/j.cell.2005.06.028 · Cited by 575 · see citing works

NPAS2: an analog of clock operative in the mammalian forebrain

Reick, M., Garcia, J. A., Dudley, C., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1060699 · Cited by 572 · see citing works

Association of intrinsic circadian period with morningness–eveningness, usual wake time, and circadian phase.

Duffy, J. F., Rimmer, D. W., & Czeisler, C. A. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.4.895 · Cited by 571 · see citing works

Light-Dependent Sequestration of TIMELESS by CRYPTOCHROME

Ceriani, M. F., Darlington, T. K., Staknis, D., Más, P., Petti, A. A., Weitz, C. J., & Kay, S. A. (1999) · Science · doi:10.1126/science.285.5427.553 · Cited by 565 · see citing works

Increased obese mRNA expression in omental fat cells from massively obese humans

Hamilton, B. S., Paglia, D., Kwan, A. Y. M., & Deitel, M. (1995) · Nature Medicine · doi:10.1038/nm0995-953 · Cited by 526 · see citing works

A Role for the Segment Polarity Gene shaggy/GSK-3 in the Drosophila Circadian Clock

Martinek, S., Inonog, S., Manoukian, A. S., & Young, M. W. (2001) · Cell · doi:10.1016/s0092-8674(01)00383-x · Cited by 513 · see citing works

Characterization of Peripheral Circadian Clocks in Adipose Tissues

Zvonic, S., Ptitsyn, A. A., Conrad, S. A., Scott, L. K., Floyd, Z. E., Kilroy, G. E., Wu, X., Goh, B. C. K., Mynatt, R. L., & Gimble, J. M. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-0873 · Cited by 495 · see citing works

Several Mutations in the Melanocortin-4 Receptor Gene Including a Nonsense and a Frameshift Mutation Associated with Dominantly Inherited Obesity in Humans

Hinney, A., Schmidt, A., Nottebom, K., Heibült, O., Becker, I., Ziegler, A., Gerber, G., Sina, M., Görg, T., Mayer, H. G., et al. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.4.5728 · Cited by 462 · see citing works

Regulation of CLOCK and MOP4 by Nuclear Hormone Receptors in the Vasculature

McNamara, P., Seo, S., Rudic, R. D., Sehgal, A., Chakravarti, D., & FitzGerald, G. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00401-9 · Cited by 441 · see citing works

CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBPPreprint

Ripperger, J. A., Shearman, L. P., Reppert, S. M., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.14.6.679 · Cited by 429 · see citing works

Overweight and obese patients in a primary care population report less sleep than patients with a normal body mass index

Vorona, R. D., Winn, M. P., Babineau, T. W., Eng, B. P., Feldman, H. R., & Ware, J. C. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.1.25 · Cited by 405 · see citing works

Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanismPreprint

Mitsui, S., Yamaguchi, S., Matsuo, T., Ishida, Y., & Okamura, H. (2001) · Genes & Development · doi:10.1101/gad.873501 · Cited by 403 · see citing works

Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity

Yıldız, B. O., Suchard, M. A., Wong, M., McCann, S. M., & Licinio, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403465101 · Cited by 385 · see citing works

A Role for Glycogen Synthase Kinase-3β in the Mammalian Circadian Clock

Iitaka, C., Miyazaki, K., Akaike, T., & Ishida, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503526200 · Cited by 373 · see citing works

Diurnal and Ultradian Dynamics of Serum Adiponectin in Healthy Men: Comparison with Leptin, Circulating Soluble Leptin Receptor, and Cortisol Patterns

Gavrila, A., Peng, C., Chan, J. L., Mietus, J. E., Goldberger, A. L., & Mantzoros, C. S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021721 · Cited by 360 · see citing works

Effect of shift work on body mass index: results of a study performed in 319 glucose-tolerant men working in a Southern Italian industry

Di Lorenzo, L., De Pergola, G., Zocchetti, C., L'Abbate, N., Basso, A., Pannacciulli, N., Cignarelli, M., Giorgino, R., & Soleo, L. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802419 · Cited by 346 · see citing works

Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference

Johansson, C., Willeit, M., Smedh, C., Ekholm, J., Paunio, T., Kieseppä, T., Lichtermann, D., Praschak-Rieder, N., Neumeister, A., Nilsson, L.-G., et al. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300121 · Cited by 341 · see citing works

Obesity Without Sleep Apnea Is Associated With Daytime Sleepiness

Vgontzas, A. N., Bixler, E. O., Tan, T. L., Kantner, D., Martin, L. F., & Kales, A. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.12.1333 · Cited by 329 · see citing works

Influence of <i>CLOCK</i> gene polymorphism on circadian mood fluctuation and illness recurrence in bipolar depression

Benedetti, F., Serretti, A., Colombo, C., Barbini, B., Lorenzi, C., Campori, E., & Smeraldi, E. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20038 · Cited by 324 · see citing works

Metabolic disturbances in male workers with rotating three-shift work. Results of the WOLF study

Karlsson, B. H., Knutsson, A., Lindahl, B., & Alfredsson, L. S. (2003) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-003-0440-y · Cited by 316 · see citing works

Rhythmic Messenger Ribonucleic Acid Expression of Clock Genes and Adipocytokines in Mouse Visceral Adipose Tissue

Ando, H., Yanagihara, H., Hayashi, Y., Obi, Y., Tsuruoka, S., Takamura, T., Kaneko, S., & Fujimura, A. (2005) · Endocrinology · doi:10.1210/en.2005-0771 · Cited by 312 · see citing works

Transcriptional oscillation of canonical clock genes in mouse peripheral tissues

Yamamoto, T., Nakahata, Y., Soma, H., Akashi, M., Mamine, T., & Takumi, T. (2004) · BMC Molecular Biology · doi:10.1186/1471-2199-5-18 · Cited by 308 · see citing works

The Suprachiasmatic Nucleus Generates the Diurnal Changes in Plasma Leptin Levels

Kalsbeek, A., Fliers, E., Romijn, J. A., la Fleur, S. E., Wortel, J., Bakker, O., Endert, E., & Buijs, R. M. (2001) · Endocrinology · doi:10.1210/endo.142.6.8197 · Cited by 305 · see citing works

Expression and Localization of the Leptin Receptor in Endocrine and Neuroendocrine Tissues of the Rat

Zamorano, P. L., Mahesh, V. B., Sevilla, L. M. D., Chorich, L. P., Bhat, G. K., & Brann, D. W. (2008) · Neuroendocrinology · doi:10.1159/000127276 · Cited by 303 · see citing works

Circadian rhythms in a nutshell

Edery, I. (2000) · Physiological Genomics · doi:10.1152/physiolgenomics.2000.3.2.59 · Cited by 284 · see citing works

GENETIC ANALYSIS OF MORNINGNESS AND EVENINGNESS

Vink, J. M., Vink, J. M., Groot, A. S., KERKHOF, G. A., & Boomsma, D. I. (2001) · Chronobiology International · doi:10.1081/cbi-100107516 · Cited by 272 · see citing works

Sleep Loss Reduces Diurnal Rhythm Amplitude of Leptin in Healthy Men

Mullington, J. M., Chan, J. L., Van Dongen, H. P. A., Szuba, M. P., Samaras, J., Price, N. J., Meier‐Ewert, H. K., Dinges, D. F., & Mantzoros, C. S. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01069.x · Cited by 261 · see citing works

Differential control of peripheral circadian rhythms by suprachiasmatic-dependent neural signals

Guo, H., Brewer, J. M., Champhekar, A. S., Harris, R. B. S., & Bittman, E. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409734102 · Cited by 258 · see citing works

Clock Genes in the Heart

Young, M. E., Razeghi, P., & Taegtmeyer, H. (2001) · Circulation Research · doi:10.1161/hh1101.091190 · Cited by 251 · see citing works

The Orphan Nuclear Receptor Rev-Erbα Is a Peroxisome Proliferator-activated Receptor (PPAR) γ Target Gene and Promotes PPARγ-induced Adipocyte Differentiation

Fontaine, C., Dubois, G., Duguay, Y., Helledie, T., Vu‐Dac, N., Gervois, P. P., Soncin, F., Mandrup, S., Fruchart, J., Fruchart‐Najib, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304664200 · Cited by 248 · see citing works

The 3111T/C polymorphism of hClock is associated with evening preference and delayed sleep timing in a Japanese population sample

Mishima, K., Tozawa, T., Satoh, K., Saito, H., & Mishima, Y. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30110 · Cited by 240 · see citing works

Independent circadian and sleep/wake regulation of adipokines and glucose in humans

Shea, S. A., Hilton, M. F., Orlova, C., Ayers, R. T., & Mantzoros, C. S. (2005) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2004-2232 · Cited by 240 · see citing works

Impaired Processing of Prohormones Associated with Abnormalities of Glucose Homeostasis and Adrenal Function

O'Rahilly, S., Gray, H., Humphreys, P. J., Krook, A., Polonsky, K. S., White, A., Gibson, S., Taylor, K., & Carr, C. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511233332104 · Cited by 237 · see citing works

Multilevel regulation of the circadian clock

Cermakian, N., & Sassone‐Corsi, P. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036078 · Cited by 226 · see citing works

Duration of shiftwork related to body mass index and waist to hip ratio

van Amelsvoort, L., Schouten, E., & Kok, F. J. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0801028 · Cited by 221 · see citing works

The intrinsic circadian clock within the cardiomyocyte

Durgan, D. J., Hotze, M. A., Tomlin, T. M., Egbejimi, O., Graveleau, C., Abel, E. D., Shaw, C. A., Bray, M. S., Hardin, P. E., & Young, M. E. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00406.2005 · Cited by 206 · see citing works

The 3111 Clock gene polymorphism is not associated with sleep and circadian rhythmicity in phenotypically characterized human subjects

Robilliard, D. L., Archer, S. N., Arendt, J., Lockley, S. W., Hack, L. M., English, J., Léger, D., Smits, M. G., Williams, A., Skene, D. J., et al. (2002) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2002.00320.x · Cited by 203 · see citing works

The suprachiasmatic nucleus controls the daily variation of plasma glucose via the autonomic output to the liver: are the clock genes involved?

Cailotto, C., La Fleur, S. E., Van Heijningen, C., Wortel, J., Kalsbeek, A., Feenstra, M., Pévet, P., & Buijs, R. M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04439.x · Cited by 191 · see citing works

Shift work and age as interactive predictors of body mass index among offshore workers

Parkes, K. R. (2002) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.648 · Cited by 182 · see citing works

Rhythmic, reciprocal ghrelin and leptin signaling: new insight in the development of obesity

Kalra, S. P., Bagnasco, M., Otukonyong, E. E., Dube, M. G., & Kalra, P. S. (2003) · Regulatory Peptides · doi:10.1016/s0167-0115(02)00305-1 · Cited by 177 · see citing works

The genetic and environmental sources of body mass index variability: the Muscatine Ponderosity Family Study.

Moll, P. P., Burns, T. L., & Lauer, R. M. (1991) · PubMed · Cited by 176 · see citing works

Circadian and Glucocorticoid Regulation of Rev-erbα Expression in Liver 1

Pineda‐Torra, I., Tsibulsky, V. P., Delaunay, F., Saladin, R., Laudet, V., Fruchart, J., Kosykh, V., & Staels, B. (2000) · Endocrinology · doi:10.1210/endo.141.10.7708 · Cited by 169 · see citing works

The Circadian Clock within the Cardiomyocyte Is Essential for Responsiveness of the Heart to Fatty Acids

Durgan, D. J., Trexler, N., Egbejimi, O., McElfresh, T. A., Suk, H. Y., Petterson, L. E., Shaw, C. A., Hardin, P. E., Bray, M. S., Chandler, M. P., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601704200 · Cited by 164 · see citing works

The Physiology and Pharmacology of Melatonin in Humans

Geoffriau, M., Brun, J., Chazot, G., & Claustrat, B. (1998) · Hormone Research in Paediatrics · doi:10.1159/000023160 · Cited by 163 · see citing works

A single nucleotide polymorphism in glycogen synthase kinase 3-β promoter gene influences onset of illness in patients affected by bipolar disorder

Benedetti, F., Bernasconi, A., Lorenzi, C., Pontiggia, A., Serretti, A., Colombo, C., & Smeraldi, E. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.10.021 · Cited by 162 · see citing works

The two PAR leucine zipper proteins, TEF and DBP, display similar circadian and tissue‐specific expression, but have different target promoter preferences.

Fonjallaz, P., Ossipow, V., Wanner, G., & Schibler, U. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00365.x · Cited by 151 · see citing works

vvd Is Required for Light Adaptation of Conidiation-Specific Genes of Neurospora crassa, but Not Circadian Conidiation

Bailey-Shrode, L. A., Lewis, Z., White, L. D., Bell‐Pedersen, D., & Ebbole, D. J. (2001) · Fungal Genetics and Biology · doi:10.1006/fgbi.2001.1264 · Cited by 149 · see citing works

THE AETIOLOGY OF OBESITY IN CHILDREN A Study of 101 Twin Pairs

BÖRJESON, M. (1976) · Acta Paediatrica · doi:10.1111/j.1651-2227.1976.tb04887.x · Cited by 142 · see citing works

Transcriptional activation of adipogenesis

Wu, Z., Puigserver, P., & Spiegelman, B. M. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00037-x · Cited by 138 · see citing works

Heritability of Morningness‐Eveningness and Self‐Report Sleep Measures in a Family‐Based Sample of 521 Hutterites

Klei, L., Reitz, P., Miller, M., Wood, J. A., Maendel, S., Gross, D., Waldner, T., Eaton, J. W., Monk, T. H., & Nimgaonkar, V. L. (2005) · Chronobiology International · doi:10.1080/07420520500397959 · Cited by 136 · see citing works

A Missense Variation in Human Casein Kinase I Epsilon Gene that Induces Functional Alteration and Shows an Inverse Association with Circadian Rhythm Sleep Disorders

Takano, A., Uchiyama, M., Kajimura, N., Mishima, K., Inoue, Y., Kamei, Y., Kitajima, T., Shibui, K., Katoh, M., Watanabe, T., et al. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300503 · Cited by 132 · see citing works

Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin

Elmquist, J. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801918 · Cited by 128 · see citing works

Effects of photoperiod and feeding level on perirenal adipose tissue metabolic activity and leptin synthesis in the ovariectomized ewe

Bocquier, F., Bonnet, M., Faulconnier, Y., et al. (1998) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:19980501 · Cited by 116 · see citing works

Diurnal variations in the responsiveness of cardiac and skeletal muscle to fatty acids

Stavinoha, M. A., RaySpellicy, J. W., Hart-Sailors, M. L., Mersmann, H. J., Bray, M. S., & Young, M. E. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00189.2004 · Cited by 109 · see citing works

Temporal Patterns of Circulating Leptin Levels in Lean and Obese Adolescents: Relationships to Insulin, Growth Hormone, and Free Fatty Acids Rhythmicity

Heptulla, R. A., Smitten, A. L., Teague, B., Tamborlane, W. V., Ma, Y.-Z., & Caprio, S. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.1.7136 · Cited by 106 · see citing works

The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences.

Falvey, E., Fleury-Olela, F., & Schibler, U. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00105.x · Cited by 105 · see citing works

Circadian regulation of gene expression in animals

Ripperger, J. A., & Schibler, U. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00220-9 · Cited by 103 · see citing works

Major gene with sex‐specific effects influences fat mass in Mexican Americans

Comuzzie, A. G., Blangero, J., Mahaney, M. C., et al. (1995) · Genetic Epidemiology · doi:10.1002/gepi.1370120505 · Cited by 99 · see citing works

Shift work as an oxidative stressor

شریفیان, س. ا., Farahani, S. S., Pasalar, P., Gharavi, M., & Aminian, O. (2005) · Journal of Circadian Rhythms · doi:10.1186/1740-3391-3-15 · Cited by 98 · see citing works

Segregation analysis of fat mass and other body composition measures derived from underwater weighing.

Rice, T., Borecki, I. B., Bouchard, C., & Rao, D. C. (1993) · Europe PMC (PubMed Central) · Cited by 94 · see citing works

Genetic Analysis of Anthropometric Measures in 11-Year-Old Twins: The Medical College of Virginia Twin Study

Bodurtha, J. N., Mosteller, M., Hewitt, J. K., et al. (1990) · Pediatric Research · doi:10.1203/00006450-199007000-00001 · Cited by 81 · see citing works

Correlative Association between N-Methyl-d-Aspartate Receptor-Mediated Expression of Period Genes in the Suprachiasmatic Nucleus and Phase Shifts in Behavior with Photic Entrainment of Clock in Hamsters

Moriya, T., Horikawa, K., Akiyama, M., & Shibata, S. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.6.1554 · Cited by 81 · see citing works

Major gene for abdominal visceral fat area in the Québec Family Study.

Bouchard, C., Rice, T., Lemieux, S., Després, J., Përusse, L., & Rao, D. C. (1996) · PubMed · Cited by 69 · see citing works

Photoperiodic programming of body weight through the neuroendocrine hypothalamus

Morgan, P. J., Ross, A., Mercer, J., & Barrett, P. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1770027 · Cited by 66 · see citing works

Effect of feeding on peripheral circadian rhythms and behaviour in mammals

Kobayashi, H., Oishi, K., Hanai, S., & Ishida, N. (2004) · Genes to Cells · doi:10.1111/j.1365-2443.2004.00769.x · Cited by 62 · see citing works

A circadian rhythm in lipid mobilization which is altered in IDDM

Toft, E., Bolinder, J., Ungerstedt, U., & Arner, P. (1997) · Diabetologia · doi:10.1007/s001250050789 · Cited by 61 · see citing works

cDNA Cloning of a Novel bHLH-PAS Transcription Factor Superfamily Gene, BMAL2: Its mRNA Expression, Subcellular Distribution, and Chromosomal Localization

Ikeda, M., Yu, W., Hirai, M., Ebisawa, T., Honma, S., Yoshimura, K., Honma, K.-I., & Nomura, M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3248 · Cited by 61 · see citing works

Does the ventromedial hypothalamic nucleus contain a self-sustained circadian oscillator associated with periodic feedings?

Inouye, S. T. (1983) · Brain Research · doi:10.1016/0006-8993(83)90162-2 · Cited by 60 · see citing works

Effect of shift work on body mass index: results of a study performed in 319 glucose-tolerant men working in a Southern Italian industry. Int J Obes Relat Metab Disord

Lorenzo, L. D., De Pergola, G., Zocchetti, C., L'ABBATE, N., Basso, A., Pannacciulli, N., Cignarelli, M., GIORGINO, R., & Soleo, L. (2003) · CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) · Cited by 55 · see citing works

Maturation of TonEBP expression in developing rat kidney

Han, K., Woo, S. K., Kim, W.-Y., Park, S.-H., Cha, J., Kim, J., & Kwon, H. M. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00047.2004 · Cited by 54 · see citing works

Effects of photoperiod and feeding level on adipose tissue and muscle lipoprotein lipase activity and mRNA level in dry non-pregnant sheep

Faulconnier, Y., Bonnet, M., Bocquier, F., et al. (2001) · British Journal Of Nutrition · doi:10.1079/bjn2000275 · Cited by 47 · see citing works

Commingling analysis of generalized body mass and composition measures: the Québec Family Study.

Borecki, I. B., Rice, T., Bouchard, C., et al. (1991) · PubMed · Cited by 42 · see citing works

The cyanobacterial circadian system: a clock apart

Golden, S. S., Johnson, C. H., & Kondo, T. (1998) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(98)80113-6 · Cited by 38 · see citing works

Diurnal changes in lipolytic activity of isolated fat cells and their increased responsiveness to epinephrine and theophylline with meal feeding in rats.

Suzuki, M., Shimomura, Y., & SATOH, Y. (1983) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.29.399 · Cited by 30 · see citing works

Circadian and Glucocorticoid Regulation of Rev-erb Expression in Liver

Torra, I. P. (2000) · Endocrinology · doi:10.1210/en.141.10.3799 · Cited by 27 · see citing works

Circadian phase difference of leptin in android versus gynoid obesity

Perfetto, F., Tarquini, R., Cornélissen, G., Mello, G., Tempestini, A., Gaudiano, P., Mancuso, F., & Franz Halberg, A. (2004) · Peptides · doi:10.1016/j.peptides.2004.06.005 · Cited by 20 · see citing works

Longitudinally Sampled Human Plasma Leptin and Cortisol Concentrations Are Inversely Correlated

Licinio, J. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4668-3 · Cited by 20 · see citing works

Genetic dissection of drug effects in clinical practice: CLOCK gene and clozapine-induced diurnal sleepiness

Lattuada, E., Cavallaro, R., Benedetti, F., Cocchi, F., Lorenzi, C., & Smeraldi, E. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.05.084 · Cited by 16 · see citing works

Circadian regulation of a transcription factor, ApC/EBP, in the eye of Aplysia californica

Hattar, S. S., Lyons, L. C., Dryer, L., & Eskin, A. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01249.x · Cited by 16 · see citing works

Liver and peripheral tissue glycogen metabolism in obese mice: effect of a mixed meal

Chen, C., Williams, P. F., & Caterson, I. D. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.5.e743 · Cited by 12 · see citing works

Differential Effects of Multiple Short Day Lengths on Body Weights of Gonadectomized Siberian Hamsters

Gorman, M. R. (2003) · Physiological and Biochemical Zoology · doi:10.1086/374284 · Cited by 11 · see citing works

Linkage of serum leptin levels in families with sleep apnea

Larkin, E. K., Elston, R. C., Patel, S. R., et al. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802872 · Cited by 9 · see citing works

Female with autistic disorder and monosomy X (Turner syndrome): Parent-of-origin effect of the X chromosome

Donnelly, S. L., Wolpert, C. M., Menold, M. M., Bass, M. P., Gilbert, J. R., Cuccaro, M. L., Delong, G. R., & Pericak-Vance, M. A. (2000) · American Journal of Medical Genetics · doi:10.1002/1096-8628(20000612)96:3

Light at night increases body mass by shifting the time of food intake

Fonken, L. K., Workman, J. L., Walton, J. C., Weil, Z. M., Morris, J. S., Haim, A., & Nelson, R. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008734107 · Cited by 796 · see citing works

Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease

Smith, R. L., Soeters, M. R., Wüst, R. C. I., & Houtkooper, R. H. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00211 · Cited by 787 · see citing works

Metabolism and Circadian Rhythms—Implications for Obesity

Froy, O. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0014 · Cited by 505 · see citing works

Obesity and shift work: chronobiological aspects

Antunes, L. C., Levandovski, R., Dantas, G., Caumo, W., & Hidalgo, M. P. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000016 · Cited by 493 · see citing works

The association between sleep duration and weight gain in adults: A 6-year prospective study from the Quebec Family Study

Chaput, J.-P., Després, J.-P., Bouchard, C., & Tremblay, A. (2008) · Sleep · doi:10.1093/sleep/31.4.517 · Cited by 390 · see citing works

The Circadian Syndrome: is the Metabolic Syndrome and much more!

Zimmet, P., Alberti, K. G. M. M., Stern, N., Bilu, C., El‐Osta, A., Einat, H., & Kronfeld‐Schor, N. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12924 · Cited by 387 · see citing works

Sleep and circadian rhythms: key components in the regulation of energy metabolism

Laposky, A. D., Bass, J., Kohsaka, A., & Turek, F. W. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.06.079 · Cited by 351 · see citing works

The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective

Cussotto, S., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.04.002 · Cited by 326 · see citing works

Circadian regulation of lipid mobilization in white adipose tissues

Shostak, A., Meyer-Kovac, J., & Oster, H. (2013) · Diabetes · doi:10.2337/db12-1449 · Cited by 243 · see citing works

High-fat feeding alters the clock synchronization to light

Mendoza, J., Pévet, P., & Challet, E. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.159566 · Cited by 213 · see citing works

The midpoint of sleep is associated with dietary intake and dietary behavior among young Japanese women

Sato-Mito, N., Sasaki, S., Murakami, K., Okubo, H., Takahashi, Y., Shibata, S., Yamada, K., & Sato, K. (2011) · Sleep Medicine · doi:10.1016/j.sleep.2010.09.012 · Cited by 191 · see citing works

Potential role for peripheral circadian clock dyssynchrony in the pathogenesis of cardiovascular dysfunction

Young, M. E., & Bray, M. S. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.12.010 · Cited by 129 · see citing works

Dietary intake is associated with human chronotype as assessed by both morningness-eveningness score and preferred midpoint of sleep in young Japanese women

Sato-Mito, N., Shibata, S., Sasaki, S., & Sato, K. (2011) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2011.560563 · Cited by 117 · see citing works

Dietary fat and sleep duration in Chinese men and women

Shi, Z., McEvoy, M., Luu, J., & Attia, J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.191 · Cited by 108 · see citing works

Long work hours and adiposity among police officers in a US northeast city

Gu, J. K., Charles, L. E., Burchfiel, C. M., Fekedulegn, D., Sarkisian, K., Andrew, M. E., Ma, C., & Violanti, J. M. (2012) · Journal of Occupational &amp; Environmental Medicine · doi:10.1097/jom.0b013e31825f2bea · Cited by 75 · see citing works

Neuromedin S and U

Novak, C. M. (2009) · Endocrinology · doi:10.1210/en.2009-0448 · Cited by 12 · see citing works

The Intricate Relationship between Circadian Rhythms and Gastrointestinal Peptides in Obesity

Ribeiro, F. M., Arnaldo, L., P. Milhomem, L., S. Aguiar, S., & Franco, O. L. (2025) · Peptides · doi:10.1016/j.peptides.2025.171356 · Cited by 9 · see citing works

Melatonin Alleviates the Impairment of Muscle Bioenergetics and Protein Quality Control Systems in Leptin-Deficiency-Induced Obesity

Potes, Y., Díaz-Luis, A., Bermejo-Millo, J. C., Pérez-Martínez, Z., de Luxán-Delgado, B., Rubio-González, A., Menéndez-Valle, I., Gutiérrez-Rodríguez, J., Solano, J. J., Caballero, B., et al. (2023) · Antioxidants · doi:10.3390/antiox12111962 · Cited by 8 · see citing works

[Adipose tissue. Pathophysiology, distribution, sex differences and the role in inflammation and cancerogenesis].

Siemińśka, L. (2008) · PubMed · Cited by 29 · see citing works

Comparison of Pre-Adipocyte Yield, Growth and Differentiation Characteristics from Excised versus Aspirated Adipose Tissue

Torio‐Padron, N., Huotari, A. M., Eisenhardt, S. U., et al. (2010) · Cells Tissues Organs · doi:10.1159/000276594 · Cited by 25 · see citing works

Expression of the adrenomedullin gene in adipose tissue

Nambu, T., Arai, H., Komatsu, Y., Yasoda, A., Moriyama, K., Kanamoto, N., Itoh, H., & Nakao, K. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2005.07.006 · Cited by 45 · see citing works

Interactions between the circadian clock and metabolism: there are good times and bad times

Shi, M., & Zheng, X. (2012) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gms110 · Cited by 22 · see citing works

Influence of adipocyte size and adipose depot on the in vitro lipolytic activity and insulin sensitivity of adipose tissue in dairy cows at the end of the dry period

Koster, J. D., Broeck, W. V. D., Hulpio, L., Claeys, E., Eetvelde, M. V., Hermans, K., Hostens, M., Fievez, V., & OPSOMER, G. (2015) · Journal of Dairy Science · doi:10.3168/jds.2015-10440 · Cited by 42 · see citing works