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Epidemiology of necrotizing enterocolitis
Open accessAbstract
Necrotizing enterocolitis (NEC) is a worldwide problem that has emerged in the past 25 years as the most common gastrointestinal emergency in neonatal intensive care units (NICU). In the United States the incidence ranges from 1 to 7.7% of NICU admissions. Ninety percent of the patients are premature infants. Mucosal injury, bacterial colonization and formula feeding are the three major pathogenetic factors that have been documented in most infants who have developed NEC. However, NEC may develop only if a threshold of injury, imposed by the coincidence of at least two of three events (intestinal ischemia, pathogenic bacteria, and excess of protein substrate) is exceeded. Immunological immaturity of the gut in premature babies may represent the crucial risk factor.
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Cited by
Probiotics for prevention of necrotizing enterocolitis in preterm infants
AlFaleh, K., & Anabrees, J. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005496.pub4 · Cited by 956
Lin, H.-C., Su, B.-H., Chen, A.-C., Lin, T.-W., Tsai, C.-H., Yeh, T.-F., & Oh, W. (2005) · Pediatrics · doi:10.1542/peds.2004-1463 · Cited by 660
Falk, P. G., Hooper, L. V., Midtvedt, T., & Gordon, J. I. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.4.1157-1170.1998 · Cited by 657
Nanthakumar, N. N., Fusunyan, R. D., Sanderson, I., & Walker, W. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.11.6043 · Cited by 451
Treatment and prevention of necrotizing enterocolitis
Lee, J. S., & Polin, R. A. (2003) · Seminars in Neonatology · doi:10.1016/s1084-2756(03)00123-4 · Cited by 304
Metadata
- Authors
- Kosloske, A.
- Venue
- Acta Paediatrica
- Publisher
- Wiley
- Published
- 1994-04
- Volume
- 83
- Issue
- s396
- Pages
- 2-7
- ISSN
- 0365-1436 (ISSN-L)
- 0803-5253
- 1651-2227
- OpenAlex
- W2097900300
- Cited by
- 238
- References
- 0
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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