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Cited by 660Infant Nutrition and HealthProbiotics and Fermented FoodsNeonatal and Maternal Infections

Oral Probiotics Reduce the Incidence and Severity of Necrotizing Enterocolitis in Very Low Birth Weight Infants

Lin, Hung-Chih, Su, Bai-Horng, Chen, An-Chyi, Lin, Tsung-Wen, Tsai, Chang-Hai, Yeh, Tsu-Fuh, Oh, William·2005·Pediatrics
DOI 10.1542/peds.2004-1463
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Abstract

Objective. We evaluated the efficacy of probiotics in reducing the incidence and severity of necrotizing enterocolitis (NEC) in very low birth weight (VLBW) infants. Patients and Methods. A prospective, masked, randomized control trial was conducted to evaluate the beneficial effects of probiotics in reducing the incidence and severity of NEC among VLBW (<1500 g) infants. VLBW infants who started to fed enterally and survived beyond the seventh day after birth were eligible for the trial. They were randomized into 2 groups after parental informed consents were obtained. The infants in the study group were fed with Infloran (Lactobacillus acidophilus and Bifidobacterium infantis) with breast milk twice daily until discharged. Infants in the control group were fed with breast milk alone. The clinicians caring for the infants were blinded to the group assignment. The primary outcome was death or NEC (≥ stage 2). Results. Three hundred sixty-seven infants were enrolled: 180 in the study group and 187 in the control group. The demographic and clinical variables were similar in both groups. The incidence of death or NEC (≥ stage 2) was significantly lower in the study group (9 of 180 vs 24 of 187). The incidence of NEC (≥ stage 2) was also significantly lower in the study when compared with the control group (2 of 180 vs 10 of 187). There were 6 cases of severe NEC (Bell stage 3) in the control group and none in the study group. None of the positive blood culture grew Lactobacillus or Bifidobacterium species. Conclusion. Infloran as probiotics fed enterally with breast milk reduces the incidence and severity of NEC in VLBW infants.

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  • Different bifidobacteria species, mostly combined with St. thermophilus and/or Lb. acidophilus, have been shown to be effective in the prevention of necrotizing enterocolitis in children.

    “as well as in the prevention of necrotizing enterocolitis in children [138,145,146]”

    From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [145]

  • A commercial product containing B. infantis reduces the incidence and severity of necrotizing enterocolitis in very-low-birth-weight infants and preterm infants.

    “A commercial product containing a strain of B. infantis was able to reduce the incidence and severity of NEC in very-low-birth-weight infants (146) and in very-low-birth-weight preterm infants (147).”

    From Bifidobacteria and Their Health-Promoting Effects (2017) · cites this paper as [146]

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Authors
Lin, H.-C., Su, B.-H., Chen, A.-C., Lin, T.-W., Tsai, C.-H., Yeh, T.-F., & Oh, W.
Affiliations
  • China Medical University (TW)
  • Brown University (US)
ORCID
Chen, An-Chyi
Venue
Pediatrics
Publisher
American Academy of Pediatrics (AAP)
Published
2005-01-01
Volume
115
Issue
1
Pages
1-4
ISSN
  • 0031-4005 (ISSN-L)
  • 1098-4275
DOI
10.1542/peds.2004-1463
OpenAlex
W2098557460
Cited by
660
References
37
Citations by year
2026: 6 · 2025: 6 · 2024: 11 · 2023: 19 · 2022: 10 · 2021: 16 · 2020: 10 · 2019: 22 · 2018: 18 · 2017: 27 · 2016: 39 · 2015: 43 · 2014: 40 · 2013: 48 · 2012: 39
FWCI
52.69
Type
journal article
Language
en
Open access
closed
Locations
  • PEDIATRICS (publishedVersion)
  • PubMed (publishedVersion)
Funders
China Medical University Hospital
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
Keywords
necrotizing enterocolitis, probiotics, very low birth weight infants, Lactobacillus acidophilus, Bifidobacterium infantis, breastfeeding, enteral nutrition, NEC prevention, neonatal mortality
MeSH terms
Bifidobacterium, Female, Humans, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Lactobacillus acidophilus, Male, Milk, Human, Prospective Studies, Severity of Illness Index, Incidence, Logistic Models, Single-Blind Method, Sepsis, Infant, Very Low Birth Weight, Dietary Supplements, Probiotics, Enterocolitis, Necrotizing

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