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The development of the subplate and thalamocortical connections in the human foetal brain
Abstract
The aim of this review is to present clinically relevant data on prenatal development of thalamocortical connections in the human brain. The analysis is based on extensive Zagreb Neuroembryological Collection, including more than 500 prenatal human brains stained with various classical neurohistological, as well as modern histochemical and immunohistochemical methods. The connection of thalamocortical axons during the ‘waiting’ period with transient cortical subplate zone and subsequent synaptic engagement in the cortical plate is the main connectivity event in the late foetus and preterm infant. This connectivity is the structural substrate for the endogeneous subplate and sensory‐driven circuitry generating transient electrical phenomena and may represent a transient network in the developmental history of consciousness. Conclusion: Findings presented in this review should be considered in the management of pain in preterm infants, in searching for the vulnerability of the subplate zone in diagnostic procedures using the in vivo MRI and in revealing the developmental origin of cognitive and mental disorders.
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“SP, which contains the earliest-generated neurons, showed enrichment for mature neuronal markers and synaptic transmission, reflecting early thalamic afferent input by midgestation35.”
From Transcriptional landscape of the prenatal human brain (2014) · cites this paper as [35]
In the citing paper
“The SP is a largely transient zone beneath the CP that plays an important role in establishment of thalamocortical connectivity (see35 for review).”
From Transcriptional landscape of the prenatal human brain (2014) · cites this paper as [35]
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Metadata
- Authors
- Kostović, I., & Judaš, M.
- Affiliations
- University of Zagreb (HR)
- ORCID
- Kostović, Ivica
- Venue
- Acta Paediatrica
- Publisher
- Wiley
- Published
- 2010-07
- Volume
- 99
- Issue
- 8
- Pages
- 1119-1127
- ISSN
- 0365-1436 (ISSN-L)
- 0803-5253
- 1651-2227
- OpenAlex
- W1755908671
- Cited by
- 462
- References
- 75
- Citations by year
- 2026: 22 · 2025: 26 · 2024: 28 · 2023: 24 · 2022: 26 · 2021: 19 · 2020: 68 · 2019: 30 · 2018: 24 · 2017: 25 · 2016: 31 · 2015: 33 · 2014: 36 · 2013: 29 · 2012: 15
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Paediatrica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- subplate, thalamocortical connections, fetal brain development, cortical plate, preterm infants, pain management, consciousness development
- MeSH terms
- Afferent Pathways, Axons, Cerebral Cortex, Humans, Infant, Newborn, Infant, Premature, Neural Pathways, Staining and Labeling, Thalamus, Fetal Development
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