Effect of amine fluoride-stannous fluoride preparations on oral yeasts in the elderly: a randomised placebo-controlled trial
Abstract
OBJECTIVES: Oral yeast infections are an emerging problem among medically compromised and frail elderly. Antifungal drug resistance is also increasing because of an increase in non-albicans Candida strains in these populations. We therefore set out to study, in the randomised-controlled trial setting if the use of a topical amine fluoride-stannous fluoride combination (AmF-SnF2) could control oral Candida growth in the elderly. The hypothesis was based on earlier findings showing that in vitro this combination had antifungal efficacy. METHODS: A total of 194 nursing home residents were randomised to receive either the test mouth rinse and toothpaste or a placebo twice daily for 8 months. Of these, 136 completed the trial. Saliva samples were taken using the oral rinse method, cultivated and the strain level identified with routine microbial methods. Compliance and use of preparations was assessed by a nurse. RESULTS: Significantly at the end of the trial, less mucosal lesions were observed in the test group in comparison to controls. Total bacterial count decreased in both the groups during the trial. Candida albicans was the most prevalent strain detected both at baseline and 8 months later. Only a few subjects carried non-albicans strains. The AmF-SnF2 did not significantly affect mean oral Candida counts, but median Candida counts were reduced in the AmF-SnF2 group while an increase was seen in the placebo group. However, the differences observed were not statistically significant. Compliance among the regular elderly users slightly increased during the trial for both the groups. CONCLUSION: The number of subjects with high Candida counts decreased in the AmF-SnF2 group. Hence, the fluoride combination might be useful as a support therapy for oral candidiasis. Prevalence of non-albicans Candida strains was low in this population.
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L. rhamnosus mediates physiological effects in the mouth and has good adherence to saliva-coated surfaces.
“Functionally, L. rhamnosus mediates physiological effects in the mouth and has good adherence to saliva-coated surfaces[408,417].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [417]
Cites
Candida glabrata , an Emerging Oral Opportunistic Pathogen
Li, L., Redding, S. W., & Dongari‐Bagtzoglou, A. I. (2007) · Journal of Dental Research · doi:10.1177/154405910708600304 · Cited by 238 · see citing works
Evolution of Drug Resistance in Experimental Populations of <i>Candida albicans</i>
Cowen, L. E., Sanglard, D., Calabrese, D., Sirjusingh, C., Anderson, J. B., & Kohn, L. M. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.6.1515-1522.2000 · Cited by 207 · see citing works
Natural Defenses against Candida Colonization Breakdown in the Oral Cavities of the Elderly
Lockhart, S. R., Joly, S., Vargas, K. G., Swails-Wenger, J. A., Enger, L., & Soll, D. R. (1999) · Journal of Dental Research · doi:10.1177/00220345990780040601 · Cited by 189 · see citing works
Pelletier, R., Peter, J., Antin, C., Gonzalez, C. E., Wood, L. V., & Walsh, T. J. (2000) · Journal of Clinical Microbiology · doi:10.1128/jcm.38.4.1563-1568.2000 · Cited by 90 · see citing works
Redding, S. W., Kirkpatrick, W. R., Saville, S., Coco, B. J., White, W., Fothergill, A., Rinaldi, M., Eng, T., Patterson, T. F., & Lopez-Ribot, J. (2003) · Journal of Clinical Microbiology · doi:10.1128/jcm.41.2.619-622.2003 · Cited by 85 · see citing works
Cartledge, J. D., Midgley, J., & Gazzard, B. (1997) · AIDS · doi:10.1097/00002030-199715000-00008 · Cited by 67 · see citing works
Meurman, J. H., & Rantonen, P. J. F. (1994) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.1994.tb01185.x · Cited by 61 · see citing works
Self-citationOral Infections in Home-living Elderly Patients Admitted to an Acute Geriatric Ward
Meurman, J. H., Pajukoski, H., Snellman, S., Zeiler, S., & Sulkava, R. O. (1997) · Journal of Dental Research · doi:10.1177/00220345970760060601 · Cited by 50 · see citing works
Self-citationFluconazole-resistant Candida species in the oral flora of fluconazole-exposed HIV-positive patients
Hunter, K. D., Gibson, J. A. G., Lockhart, P. B., et al. (1998) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/s1079-2104(98)90291-8 · Cited by 45 · see citing works
Oral yeasts and coliforms in HIV‐infected individuals in Hong Kong
Tsang, C. S. P., & Samaranayake, L. P. (2000) · Mycoses · doi:10.1046/j.1439-0507.2000.00584.x · Cited by 35 · see citing works
Self-citationAzole resistance among oral Candida species isolates from AIDS patients under ketoconazole exposure
Milan, E. P., Burattini, M. N., Kallas, E. G., Fischmann, O., Costa, P. R. D. O., & Colombo, A. L. (1998) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(98)00107-2 · Cited by 32 · see citing works
Meurman, J. H., Jousimies-Somer, H. R., Suomala, P., et al. (1989) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.1989.tb00109.x · Cited by 31 · see citing works
Self-citationToxicological Analysis of Chlorhexidine in Human Serum using HPLC on a Polymer-Coated ODS Column
Kudo, K., Ikeda, N., Kiyoshima, A., et al. (2002) · Journal of Analytical Toxicology · doi:10.1093/jat/26.2.119 · Cited by 31 · see citing works
Trends in Antifungal Susceptibility among Candida sp. Urinary Isolates from 1994 and 1998
Baran, J., Klauber, E., Barczak, J., RIEDERER, K. M., & Khatib, R. (2000) · Journal of Clinical Microbiology · doi:10.1128/jcm.38.2.870-871.2000 · Cited by 22 · see citing works
Meurman, J. H., Kari, K., Äikäs, A., et al. (2001) · Special Care in Dentistry · doi:10.1111/j.1754-4505.2001.tb00221.x · Cited by 20 · see citing works
Self-citationHoegl, L., Thoma‐Greber, E., Röcken, M., & Körting, H. C. (1998) · Mycoses · doi:10.1111/j.1439-0507.1998.tb00347.x · Cited by 18 · see citing works
Anaphylactic reactions due to chlorhexidine allergy.
As, L., & Cc, H. (2001) · PubMed · Cited by 17 · see citing works
In vitro antifungal effect of amine fluoride‐stannous fluoride combination on oral Candida species
Meurman, J. H., Kari, K., Waltimo, T. M. T., Kotiranta, A. K., Inkeri, J., & Samaranayake, L. P. (2005) · Oral Diseases · doi:10.1111/j.1601-0825.2005.01156.x · Cited by 12 · see citing works
Self-citationLopez-Ribot, J. L., McAtee, R. K., Kirkpatrick, W. R., Valle, R. L., & Patterson, T. F. (1999) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.6.5.665-670.1999 · Cited by 11 · see citing works
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Koch, C. D., Gladwin, M. T., Freeman, B. A., Lundberg, J. O., Weitzberg, E., & Morris, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.015 · Cited by 186 · see citing works
- Authors
- Meurman, J. H., Pärnänen, P., Kari, K., & Samaranayake, L.
- Affiliations
- University of Helsinki (FI)
- University of Hong Kong (HK)
- Venue
- Gerodontology
- Publisher
- Wiley
- Published
- 2009-08-11
- Volume
- 26
- Issue
- 3
- Pages
- 202-209
- ISSN
- 0734-0664 (ISSN-L)
- 1741-2358
- OpenAlex
- W2052315497
- Cited by
- 13
- References
- 19
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gerodontology (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- amine fluoride, stannous fluoride, oral candidiasis, oral yeasts, Candida albicans, non-albicans Candida, nursing home residents, older adults, toothpaste, antifungal resistance, oral lesions
- MeSH terms
- Aged, Aged, 80 and over, Amines, Antifungal Agents, Candida, Candidiasis, Oral, Drug Combinations, Female, Fluorides, Topical, Humans, Male, Mouth, Mouthwashes, Nursing Homes, Oral Hygiene, Tin Fluorides, Toothpastes, Dental Care for Aged, Treatment Outcome
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