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Cola-induced hypokalaemia: pathophysiological mechanisms and clinical implications
Open accessAbstract
BACKGROUND/AIMS: The consumption of soft drinks has increased considerably during the last decades. Among them, the cola-based preparations are possibly the refreshments with the largest sales worldwide. In addition to the possible detrimental effects of moderate, chronic cola consumption, it has been proposed that the consumption of large amounts of cola-based soft drinks may result in severe hypokalaemia. METHODS: In this review, we discuss the clinical significance of these disturbances and summarise the pathophysiological mechanism that may underlie the development of this rare, but potentially severe, side effect. RESULTS/CONCLUSION: Several lines of evidence suggest that the chronic consumption of large amounts of cola soft drinks may adversely affect potassium homeostasis and result in potentially severe conditions such as hypokalaemic myopathy.
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Acute caffeine poisoning causes hypokalemia.
“Acute caffeine poisoning causes hypokalemia”
From Serum potassium level as a biomarker for acute caffeine poisoning (2020) · cites this paper as [11]
The Mechanisms of cola-induced hypokalaemia section says caffeine consumption may cause severe hypokalaemia and identifies caffeine intoxication as a suspected contributor in several cases. It does not establish that acute caffeine poisoning invariably causes hypokalaemia; the cases discussed largely involve prolonged cola consumption. (LLM, conf=0.83)
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Basrai, M., Schweinlin, A., Menzel, J., Mielke, H., Weikert, C., Dusemund, B., Putze, K., Watzl, B., Lampen, A., & Bischoff, S. C. (2019) · The Journal of Nutrition · doi:10.1093/jn/nxy303 · Cited by 71
Serum potassium level as a biomarker for acute caffeine poisoning
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Metadata
- Authors
- Tsimihodimos, V., Kakaidi, V., & Elisaf, M.
- Affiliations
- University of Ioannina (GR)
- Corresponding author
- Elisaf, M.
- Venue
- International Journal of Clinical Practice
- Publisher
- Hindawi Limited
- Published
- 2009-06
- Volume
- 63
- Issue
- 6
- Pages
- 900-902
- ISSN
- 1368-5031 (ISSN-L)
- 1742-1241
- OpenAlex
- W2046061016
- Cited by
- 40
- References
- 23
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 7 · 2014: 4 · 2013: 1 · 2012: 3
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Potassium and Related Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
- Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
- Keywords
- cola, hypokalemia, soft drinks, potassium homeostasis, pathophysiology
- MeSH terms
- Caffeine, Carbonated Beverages, Fructose, Glucose, Homeostasis, Humans, Hypokalemia, Phosphodiesterase Inhibitors, Potassium
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