The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
d‐Amino acids in the brain:d‐serine in neurotransmission and neurodegeneration
Open accessAbstract
The mammalian brain contains unusually high levels of d‐serine, a d‐amino acid previously thought to be restricted to some bacteria and insects. In the last few years, studies from several groups have demonstrated that d‐serine is a physiological co‐agonist of the N‐methyl d‐aspartate (NMDA) type of glutamate receptor – a key excitatory neurotransmitter receptor in the brain.d‐Serine binds with high affinity to a co‐agonist site at the NMDA receptors and, along with glutamate, mediates several important physiological and pathological processes, including NMDA receptor transmission, synaptic plasticity and neurotoxicity. In recent years, biosynthetic, degradative and release pathways for d‐serine have been identified, indicating that d‐serine may function as a transmitter. At first,d‐serine was described in astrocytes, a class of glial cells that ensheathes neurons and release several transmitters that modulate neurotransmission. This led to the notion that d‐serine is a glia‐derived transmitter (or gliotransmitter). However, recent data indicate that serine racemase, the d‐serine biosynthetic enzyme, is widely expressed in neurons of the brain, suggesting that d‐serine also has a neuronal origin. We now review these findings, focusing on recent questions regarding the roles of glia versus neurons in d‐serine signaling.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572
The National Center for Biotechnology Information
Benson, D., Boguski, M., Lipman, D. J., & Ostell, J. (1990) · Genomics · doi:10.1016/0888-7543(90)90583-g · Cited by 5,126
Glycine potentiates the NMDA response in cultured mouse brain neurons
Johnson, J. W., & Ascher, P. (1987) · Nature · doi:10.1038/325529a0 · Cited by 3,139
The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death
Choi, D. W., & Rothman, S. M. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.001131 · Cited by 2,223
Requirement for Glycine in Activation of NMDA-Receptors Expressed in Xenopus Oocytes
Kleckner, N. W., & Dingledine, R. (1988) · Science · doi:10.1126/science.2841759 · Cited by 1,422
From charcot to lou gehrig: deciphering selective motor neuron death in als
Cleveland, D. W., & Rothstein, J. D. (2001) · Nature Reviews Neuroscience · doi:10.1038/35097565 · Cited by 1,389
Synaptic plasticity, memory and the hippocampus: a neural network approach to causality
Neves, G., Cooke, S. F., & Bliss, T. V. P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2303 · Cited by 1,210
UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS
Bruijn, L. I., Miller, T. M., & Cleveland, D. W. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144244 · Cited by 1,185
d -Serine is an endogenous ligand for the glycine site of the N -methyl- d -aspartate receptor
Mothet, J.-P., Parent, A. T., Wolosker, H., Brady, R. O., Linden, D. J., Ferris, C. D., Rogawski, M. A., & Snyder, S. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.9.4926 · Cited by 1,137
Self-citationMice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia
Mohn, A. R., Gainetdinov, R. R., Caron, M. G., & Koller, B. H. (1999) · Cell · doi:10.1016/s0092-8674(00)81972-8 · Cited by 1,075
Cited by
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Traynelis, S. F., Wollmuth, L. P., McBain, C. J., Menniti, F. S., Vance, K. M., Ogden, K. K., Hansen, K. B., Yuan, H., Myers, S. J., & Dingledine, R. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002451 · Cited by 3,568
Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms
Zanos, P., Moaddel, R., Morris, P. J., Riggs, L. M., Highland, J. N., Georgiou, P., Pereira, E. F. R., Albuquerque, E. X., Thomas, C. J., Zarate, C. A., et al. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.015198 · Cited by 1,260
Gut Bacteria and Neurotransmitters
Dicks, L. M. T. (2022) · Microorganisms · doi:10.3390/microorganisms10091838 · Cited by 482
Michard, E., Lima, P. T., Borges, F., Silva, A. C., Portes, M. T., Carvalho, J. E., Gilliham, M., Liu, L.-H., Obermeyer, G., & Feijó, J. A. (2011) · Science · doi:10.1126/science.1201101 · Cited by 417
Genchi, G. (2017) · Amino Acids · doi:10.1007/s00726-017-2459-5 · Cited by 283
Metadata
- Authors
- Wolosker, H., Dumin, E., Balan, L., & Foltyn, V. N.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2008-07
- Volume
- 275
- Issue
- 14
- Pages
- 3514-3526
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W2125269329
- Cited by
- 309
- References
- 98
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: d‐Amino acids in the brain:d‐serine in neurotransmission and neurodegeneration. https://app.cochat.ai/papers/10.1111/j.1742-4658.2008.06515.x
- The paper
- Wolosker, H., Dumin, E., Balan, L., & Foltyn, V. N. (2008). d‐Amino acids in the brain:d‐serine in neurotransmission and neurodegeneration. The FEBS Journal. https://doi.org/10.1111/j.1742-4658.2008.06515.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
