UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS

Bruijn, Lucie I.; Miller, Timothy M.; Cleveland, Don W.

doi:10.1146/annurev.neuro.27.070203.144244

Cited by 1,185

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UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS

Bruijn, Lucie I., Miller, Timothy M., Cleveland, Don W.·2004·Annual Review of Neuroscience

DOI 10.1146/annurev.neuro.27.070203.144244

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Abstract

▪ Abstract Although Charcot described amyotrophic lateral sclerosis (ALS) more than 130 years ago, the mechanism underlying the characteristic selective degeneration and death of motor neurons in this common adult motor neuron disease has remained a mystery. There is no effective remedy for this progressive, fatal disorder. Modern genetics has now identified mutations in one gene [Cu/Zn superoxide dismutase (SOD1)] as a primary cause and implicated others [encoding neurofilaments, cytoplasmic dynein and its processivity factor dynactin, and vascular endothelial growth factor (VEGF)] as contributors to, or causes of, motor neuron diseases. These insights have enabled development of model systems to test hypotheses of disease mechanism and potential therapies. Along with errors in the handling of synaptic glutamate and the potential excitotoxic response this provokes, these model systems highlight the involvement of nonneuronal cells in disease progression and provide new therapeutic strategies.

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The ALS-linked G93A mutation of SOD1 allowed the establishment of a mouse model featuring MN degeneration in the spinal cord.
“The ALS-linked G93A mutation of SOD1 allowed the establishment of a mouse model, featuring MN degeneration in the SC4.”
From Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis (2020) · cites this paper as [4]

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062
ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions
Bruijn, L. I., Becher, M. W., Lee, M. K., Anderson, K. L., Jenkins, N. A., Copeland, N. G., Sisodia, S. S., Rothstein, J. D., Borchelt, D. R., Price, D. L., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80272-x · Cited by 1,341
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Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
Steffan, J. S., Bodai, L., Pallos, J., Poelman, M., McCampbell, A., Apostol, B. L., Kazantsev, A., Schmidt, E., Zhu, Y.-Z., Greenwald, M., et al. (2001) · Nature · doi:10.1038/35099568 · Cited by 1,228

Flagged first, then by citations

Research works printed but not linked: 156

10.1086/377156 · DOI
10.1093/hmg/8.2.157 · DOI
10.1002/ana.10638 · DOI
10.1002/ana.410360608 · DOI
10.1212/WNL.57.7.1282 · DOI
10.1212/WNL.58.8.1277 · DOI
10.1016/0014-4886(92)90232-F · DOI
10.1523/JNEUROSCI.22-03-00629.2002 · DOI
10.1038/nm0295-168 · DOI
10.1080/14660820052415899 · DOI
10.1080/14660820152415726 · DOI
10.1038/86439 · DOI
10.1002/1531-8249(200004)47:4<447::AID-ANA7>3.0.CO;2-R · DOI
10.1046/j.1471-4159.1998.71052041.x · DOI
10.1002/ana.410420416 · DOI
10.1083/jcb.147.3.531 · DOI
10.1038/364584a0 · DOI
10.1016/S0079-6123(08)61151-6 · DOI
10.1016/0022-510X(96)00013-5 · DOI
Blair IP, 2000, Neurogenetics, 3, 1, 10.1007/PL00022976 · DOI
10.1073/pnas.91.17.8292 · DOI
10.1046/j.1471-4159.1995.64052366.x · DOI
10.1126/science.290.5497.1775 · DOI
10.1046/j.1471-4159.1999.0720693.x · DOI
10.1073/pnas.94.14.7606 · DOI
10.1111/j.1365-2990.1996.tb00907.x · DOI
10.1126/science.281.5384.1851 · DOI
10.1038/nn1002-919a · DOI
10.1212/WNL.18.9.841 · DOI
10.1097/00005072-197107000-00005 · DOI
10.1126/science.288.5471.1660 · DOI
10.1126/science.1086071 · DOI
10.1097/00005072-199209000-00008 · DOI
10.1073/pnas.95.11.6361 · DOI
10.1073/pnas.95.16.9626 · DOI
10.1074/jbc.272.38.23469 · DOI
Dal Canto MC, 1994, Am. J. Pathol., 145, 1271
10.1016/S0092-8674(00)80629-7 · DOI
10.1002/1531-8249(20010201)49:2<245::AID-ANA45>3.0.CO;2-A · DOI
10.1016/0022-510X(84)90199-0 · DOI
10.1046/j.1474-9728.2003.00054.x · DOI
10.1002/ana.10374 · DOI
10.1016/S0169-328X(01)00242-X · DOI
10.1212/WNL.47.4_Suppl_2.47S · DOI
10.1126/science.286.5449.2498 · DOI · Paper page
10.1074/jbc.M304296200 · DOI
10.1093/hmg/3.10.1757 · DOI
10.1523/JNEUROSCI.22-03-00612.2002 · DOI
10.1083/jcb.200308159 · DOI
10.1080/14660820050515377 · DOI
10.1086/340427 · DOI
Gonatas NK, 1992, Am. J. Pathol., 140, 731
10.1006/exnr.2000.7323 · DOI
10.1523/JNEUROSCI.20-02-00660.2000 · DOI
10.1111/j.1749-6632.2001.tb03591.x · DOI
10.1523/JNEUROSCI.21-17-06569.2001 · DOI
10.1056/NEJM199412223312516 · DOI
10.1038/ng1001-166 · DOI
10.1126/science.1083129 · DOI
10.1212/WNL.61.6.750 · DOI · Paper page
10.1002/(SICI)1097-4547(19980701)53:1<66::AID-JNR7>3.0.CO;2-H · DOI
10.1086/337945 · DOI
10.1002/glia.10161 · DOI · Paper page
10.1046/j.1471-4159.2002.00968.x · DOI
10.1007/s100480050052 · DOI
10.1523/JNEUROSCI.22-06-j0001.2002 · DOI
Hirano A, 1991, Adv. Neurol., 56, 91
10.1097/00005072-198409000-00002 · DOI
10.1212/01.WNL.0000069922.32557.CA · DOI · Paper page
10.1001/jama.284.13.1664 · DOI
10.1073/pnas.032539299 · DOI
10.1111/j.1365-2990.1993.tb00443.x · DOI
10.1007/s004010050535 · DOI
10.1006/nbdi.2000.0299 · DOI
Jaarsma D, 2001, Acta Neuropathol. (Berlin), 102, 293, 10.1007/s004010100399 · DOI
10.1073/pnas.95.7.3489 · DOI
10.1073/pnas.220417997 · DOI
10.1093/brain/awh005 · DOI
10.1126/science.1086137 · DOI · Paper page
10.1080/14660820050515160 · DOI
Kawamata T, 1992, Am. J. Pathol., 140, 691
10.1097/00005072-198111000-00008 · DOI
10.1038/71338 · DOI
10.1038/6568 · DOI · Paper page
10.1523/JNEUROSCI.18-09-03241.1998 · DOI
10.1126/science.277.5325.559 · DOI
10.1016/0166-2236(96)10049-7 · DOI · Paper page
10.1006/nbdi.2002.0487 · DOI
10.1006/geno.2000.6379 · DOI
10.1038/ng1211 · DOI
10.1016/S0896-6273(02)00696-7 · DOI
10.1016/S0969-9961(03)00036-6 · DOI
10.1146/annurev.ne.19.030196.001155 · DOI
Leigh PN, 1991, Adv. Neurol., 56, 115
10.1093/brain/114.2.775 · DOI
10.1126/science.288.5464.335 · DOI
10.1016/S0896-6273(00)80997-6 · DOI
10.1523/JNEUROSCI.22-12-04825.2002 · DOI · Paper page
10.1074/jbc.M007891200 · DOI
10.1021/bi000846f · DOI
10.1016/S0893-133X(01)00357-8 · DOI
10.1111/j.1365-2990.1993.tb00419.x · DOI
10.1074/jbc.M203065200 · DOI
McGeer EG, 1999, Curr. Pharm. Des., 5, 821, 10.2174/1381612805666230111212056 · DOI
10.1086/302962 · DOI
Mulder DW, 1987, Adv. Exp. Med. Biol., 209, 325
10.1212/WNL.36.4.511 · DOI
10.1523/JNEUROSCI.21-23-09246.2001 · DOI
10.1046/j.0953-816x.2001.01512.x · DOI
10.1002/ana.1256 · DOI
10.1016/S0896-6273(01)00268-9 · DOI
10.1074/jbc.M206559200 · DOI
10.1038/88842 · DOI · Paper page
10.1016/S0896-6273(00)80151-8 · DOI
10.1093/hmg/ddg184 · DOI
10.1073/pnas.95.15.8428 · DOI
10.1073/pnas.240305897 · DOI
10.1523/JNEUROSCI.21-10-03369.2001 · DOI · Paper page
10.1038/ng1123 · DOI
10.1126/science.284.5415.805 · DOI
10.1016/S0896-6273(02)00905-4 · DOI
10.1038/ng0596-43 · DOI
10.1073/pnas.92.3.689 · DOI
10.1083/jcb.200205027 · DOI
10.1016/S0896-6273(00)80086-0 · DOI · Paper page
10.1002/ana.410300223 · DOI
10.1002/ana.410280106 · DOI
10.1002/ana.410380114 · DOI · Paper page
10.1086/377157 · DOI
10.1086/377158 · DOI
10.1073/pnas.211352598 · DOI
10.1006/neur.1995.0026 · DOI
10.1159/000111445 · DOI
10.1074/jbc.M010759200 · DOI
10.1002/ana.1104 · DOI
10.1038/nn823 · DOI
10.1038/ng0594-79 · DOI
10.1074/jbc.M209356200 · DOI
10.1126/science.276.5319.1699 · DOI
10.1097/00001756-199812010-00036 · DOI
10.1074/jbc.M003779200 · DOI
10.1097/00001756-200206120-00018 · DOI
10.1523/JNEUROSCI.20-24-09119.2000 · DOI
10.1093/hmg/ddg312 · DOI
10.1006/nbdi.2002.0498 · DOI
10.1016/S0092-8674(02)00835-8 · DOI
10.1126/science.271.5248.515 · DOI
Wilhelmsen KC, 1997, J. Neural Transm. Suppl., 49, 269
10.1073/pnas.95.16.9631 · DOI
10.1126/science.288.5465.399a · DOI
10.1016/0896-6273(95)90259-7 · DOI
10.1073/pnas.040461197 · DOI
10.1073/pnas.2635267100 · DOI
10.1038/ng1001-160 · DOI · Paper page
10.1073/pnas.96.23.13496 · DOI
10.1038/417074a · DOI

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Authors: Bruijn, L. I., Miller, T. M., & Cleveland, D. W.
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 2004-07-21
Volume: 27
Issue: 1
Pages: 723-749
ISSN: 0147-006X
1545-4126
DOI: 10.1146/annurev.neuro.27.070203.144244
Cited by: 1,185
References: 3
Language: en

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UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS

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