The DOI matches its Crossref record; 164 of the 164 references it cites were found in a registry or an index.
Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis
Open accessAbstract
Snake venoms are cocktails of enzymes and non‐enzymatic proteins used for both the immobilization and digestion of prey. The most common snake venom enzymes include acetylcholinesterases,l‐amino acid oxidases, serine proteinases, metalloproteinases and phospholipases A 2. Higher catalytic efficiency, thermal stability and resistance to proteolysis make these enzymes attractive models for biochemists, enzymologists and structural biologists. Here, we review the structures of these enzymes and describe their structure‐based mechanisms of catalysis and inhibition. Some of the enzymes exist as protein complexes in the venom. Thus we also discuss the functional role of non‐enzymatic subunits and the pharmacological effects of such protein complexes. The structures of inhibitor–enzyme complexes provide ideal platforms for the design of potent inhibitors which are useful in the development of prototypes and lead compounds with potential therapeutic applications.
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Snake Antivenom: Challenges and Alternate Approaches
Alangode, A., Rajan, K., & Nair, B. G. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114135 · Cited by 88
Costal-Oliveira, F., Stransky, S., Guerra-Duarte, C., Naves de Souza, D. L., Vivas-Ruiz, D. E., Yarlequé, A., Sanchez, E. F., Chávez-Olórtegui, C., & Braga, V. M. M. (2019) · Scientific Reports · doi:10.1038/s41598-018-37435-4 · Cited by 86
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Xiong, S., & Huang, C. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.02.004 · Cited by 78
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Metadata
- Authors
- Kang, T. S., Georgieva, D., Genov, N., Murakami, M. T., Sinha, M., Kumar, R. P., Kaur, P., Kumar, S., Dey, S., Sharma, S., Vrielink, A., Betzel, C., Takeda, S., Arni, R. K., Singh, T. P., & Kini, R. M.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2011-05-17
- Volume
- 278
- Issue
- 23
- Pages
- 4544-4576
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W1888357425
- Cited by
- 315
- References
- 164
- FWCI
- 9.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kang, T. S., Georgieva, D., Genov, N., Murakami, M. T., Sinha, M., Kumar, R. P., Kaur, P., Kumar, S., Dey, S., Sharma, S., Vrielink, A., Betzel, C., Takeda, S., Arni, R. K., Singh, T. P., & Kini, R. M. (2011). Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis. The FEBS Journal. https://doi.org/10.1111/j.1742-4658.2011.08115.x
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