The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Up‐regulated long non‐coding RNA H19 contributes to proliferation of gastric cancer cells
Open accessAbstract
Long non‐coding RNAs (lncRNAs) have been shown to have important regulatory roles in cancer biology, and the lncRNA H19 is up‐regulated in hypoxic stress and in some tumors. However, the contributions of H19 to gastric cancer remain largely unknown. In this study, we assayed the H19 expression level in gastric cancer tissues by real‐time PCR, and defined the biological functions by flow cytometry and RNA immunoprecipitation. We demonstrated that H19 levels were markedly increased in gastric cancer cells and gastric cancer tissues compared with normal controls. Moreover, ectopic expression of H19 increased cell proliferation, whereas H19 siRNA treatment contributed to cell apoptosis in AGS cell line. We further verified that H19 was associated with p53, and that this association resulted in partial p53 inactivation. These data suggest an important role for H19 in the molecular etiology of gastric cancer and potential application of H19 in gastric cancer therapy.
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Long non-coding RNAs: insights into functions
Mercer, T. R., Dinger, M. E., & Mattick, J. S. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2521 · Cited by 5,654
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Gupta, R. A., Shah, N., Wang, K. C., Kim, J., Horlings, H. M., Wong, D. J., Tsai, M.-C., Hung, T., Argani, P., Rinn, J. L., et al. (2010) · Nature · doi:10.1038/nature08975 · Cited by 5,218
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Tsai, M.-C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., Lan, F., Shi, Y., Segal, E., & Chang, H. Y. (2010) · Science · doi:10.1126/science.1192002 · Cited by 3,290
Long noncoding RNAs: functional surprises from the RNA world
Wilusz, J. E., Sunwoo, H., & Spector, D. L. (2009) · Genes & Development · doi:10.1101/gad.1800909 · Cited by 2,294
A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response
Huarte, M., Guttman, M., Feldser, D., Garber, M., Koziol, M. J., Kenzelmann-Broz, D., Khalil, A. M., Zuk, O., Amit, I., Rabani, M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.040 · Cited by 2,053
The functional role of long non-coding RNA in human carcinomas
Gibb, E. A., Brown, C. J., & Lam, W. L. (2011) · Molecular Cancer · doi:10.1186/1476-4598-10-38 · Cited by 1,619
Kogo, R., Shimamura, T., Mimori, K., Kawahara, K., Imoto, S., Sudo, T., Tanaka, F., Shibata, K., Suzuki, A., Komune, S., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1021 · Cited by 1,238
Genome-wide transcription and the implications for genomic organization
Kapranov, P., Willingham, A. T., & Gingeras, T. R. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2083 · Cited by 720
The H19 Non-Coding RNA Is Essential for Human Tumor Growth
Matouk, I. J., DeGroot, N., Mezan, S., Ayesh, S., Abu-lail, R., Hochberg, A., & Galun, E. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000845 · Cited by 650
microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer
Braconi, C., Kogure, T., Valeri, N., Huang, N., Nuovo, G., Costinean, S., Negrini, M., Miotto, E., Croce, C. M., & Patel, T. (2011) · Oncogene · doi:10.1038/onc.2011.193 · Cited by 642
Cited by
Luo, M., Li, Z., Wang, W., Zeng, Y., Liu, Z., & Qiu, J. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.01.033 · Cited by 549
Targeting long non-coding RNAs in cancers: Progress and prospects
Li, C. H., & Chen, Y. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.05.030 · Cited by 473
MALAT1: a druggable long non-coding RNA for targeted anti-cancer approaches
Amodio, N., Raimondi, L., Juli, G., Stamato, M. A., Caracciolo, D., Tagliaferri, P., & Tassone, P. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0606-4 · Cited by 348
Signaling pathways and therapeutic interventions in gastric cancer
Lei, Z.-N., Teng, Q.-X., Tian, Q., Chen, W., Xie, Y., Wu, K., Zeng, Q., Zeng, L., Pan, Y., Chen, Z.-S., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01190-w · Cited by 322
ZHAO, Y., GUO, Q., CHEN, J., HU, J., WANG, S., & SUN, Y. (2014) · Oncology Reports · doi:10.3892/or.2013.2850 · Cited by 260
Metadata
- Authors
- Yang, F., Bi, J., Xue, X., Zheng, L., Zhi, K., Hua, J., & Fang, G.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2012-07-31
- Volume
- 279
- Issue
- 17
- Pages
- 3159-3165
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W1552793640
- Cited by
- 464
- References
- 27
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yang, F., Bi, J., Xue, X., Zheng, L., Zhi, K., Hua, J., & Fang, G. (2012). Up‐regulated long non‐coding RNA H19 contributes to proliferation of gastric cancer cells. The FEBS Journal. https://doi.org/10.1111/j.1742-4658.2012.08694.x
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