The DOI matches its Crossref record; 182 of the 182 references it cites were found in a registry or an index.
MALAT1: a druggable long non-coding RNA for targeted anti-cancer approaches
Open accessAbstract
The deeper understanding of non-coding RNAs has recently changed the dogma of molecular biology assuming protein-coding genes as unique functional biological effectors, while non-coding genes as junk material of doubtful significance. In the last decade, an exciting boom of experimental research has brought to light the pivotal biological functions of long non-coding RNAs (lncRNAs), representing more than the half of the whole non-coding transcriptome, along with their dysregulation in many diseases, including cancer.In this review, we summarize the emerging insights on lncRNA expression and functional role in cancer, focusing on the evolutionary conserved and abundantly expressed metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) that currently represents the best characterized lncRNA. Altogether, literature data indicate aberrant expression and dysregulated activity of MALAT1 in human malignancies and envision MALAT1 targeting as a novel treatment strategy against cancer.
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1 retracted
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Potential Therapeutic Targeting of lncRNAs in Cholesterol Homeostasis
Ye, W.-C., Huang, S.-F., Hou, L.-J., Long, H.-J., Yin, K., Hu, C. Y., & Zhao, G.-J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.688546 · Cited by 19
Non-Coding RNAs in Multiple Myeloma Bone Disease Pathophysiology
Raimondi, L., De Luca, A., Giavaresi, G., Raimondo, S., Gallo, A., Taiana, E., Alessandro, R., Rossi, M., Neri, A., Viglietto, G., et al. (2020) · Non-Coding RNA · doi:10.3390/ncrna6030037 · Cited by 16
Self-citation
Metadata
- Authors
- Amodio, N., Raimondi, L., Juli, G., Stamato, M. A., Caracciolo, D., Tagliaferri, P., & Tassone, P.
- Venue
- Journal of Hematology & Oncology
- Published
- 2018-05-08
- Volume
- 11
- Issue
- 1
- Pages
- 63-63
- ISSN
- 1756-8722 (ISSN-L)
- OpenAlex
- W2806353550
- Cited by
- 348
- References
- 182
- FWCI
- 10.43
- Type
- journal article
- Language
- en
- Open access
- gold
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- Amodio, N., Raimondi, L., Juli, G., Stamato, M. A., Caracciolo, D., Tagliaferri, P., & Tassone, P. (2018). MALAT1: a druggable long non-coding RNA for targeted anti-cancer approaches. Journal of Hematology & Oncology. https://doi.org/10.1186/s13045-018-0606-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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