Cited by 257Birth, Development, and HealthHealth, Environment, Cognitive AgingStatistical Methods in Epidemiology

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Assessing Intrauterine Influences on Offspring Health Outcomes: Can Epidemiological Studies Yield Robust Findings?

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Smith, George Davey·2008·Basic & Clinical Pharmacology & Toxicology

DOI 10.1111/j.1742-7843.2007.00191.x

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Abstract

Abstract: The influence of factors acting during the intrauterine period on health outcomes of offspring is of considerable research and public health interest. There are, however, methodological challenges in establishing robust causal links, because exposures often act many decades before outcomes of interest, may act before it is evident that women are pregnant and would enter pregnancy birth cohorts, and may also be strongly related to other factors, generating considerable degrees of potential confounding. The degree of confounding can sometimes be estimated by comparing the association between exposures experienced by the mother during pregnancy and outcomes among the offspring with the association of exposures experienced by the father during the pregnancy period and offspring outcomes. If the effects are due to an intrauterine exposure, then maternal exposure during pregnancy should have a clearly greater influence than paternal exposure. A different approach is that of Mendelian randomization, which utilizes genetic variants of known functional effect that can proxy for modifiable exposures. If carried by the mother, these variants would influence the intrauterine environment experienced by her offspring. These genetic variants are stable over time and can be assessed after pregnancy is complete or even after outcomes in the offspring have been observed. The variants would also not generally be related to potential confounding factors. Other epidemiological strategies are briefly reviewed. It is concluded that the naïve acceptance of findings utilizing conventional epidemiological methods in this setting is misplaced.

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‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*
Davey Smith, G., & Ebrahim, S. (2003) · International Journal of Epidemiology · doi:10.1093/ije/dyg070 · Cited by 5,882
Information Theory, Inference, and Learning Algorithms
(2004) · Kybernetes · doi:10.1108/03684920410534506 · Cited by 4,937
The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers
(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737
Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology
Lawlor, D. A., Harbord, R. M., Sterne, J. A. C., Timpson, N., & Davey Smith, G. (2008) · Statistics in Medicine · doi:10.1002/sim.3034 · Cited by 4,618
Self-citation
A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity
Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., Perry, J. R. B., Elliott, K. S., Lango, H., Rayner, N. W., et al. (2007) · Science · doi:10.1126/science.1141634 · Cited by 4,531
Self-citation
Identification of Causal Effects Using Instrumental Variables
Angrist, J. D., Imbens, G. W., & Rubin, D. B. (1996) · Journal of the American Statistical Association · doi:10.1080/01621459.1996.10476902 · Cited by 4,230
Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial
(1999) · The Lancet · doi:10.1016/s0140-6736(99)07072-5 · Cited by 3,812
Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease
Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L., Valanis, B., Williams, J. H., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341802 · Cited by 3,638
Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study
(1991) · The Lancet · doi:10.1016/0140-6736(91)90133-a · Cited by 3,472
Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation
Czeizel, A. E., & Dudás, I. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212243272602 · Cited by 3,200

Show all 94 references

Research works printed but not linked: 2

Manson J, 1991, A prospective study of antioxidant vitamins and incidence of coronary heart disease in women, Circulation, 84, II
Davey Smith G, 2007, Bio‐Social Surveys: Current Insight and Future Promise

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Authors: Smith, G. D.
Affiliations: University of Bristol (GB)
Corresponding author: Smith, George Davey
ORCID: Smith, George Davey
Venue: Basic & Clinical Pharmacology & Toxicology
Publisher: Wiley
Published: 2008-01-22
Volume: 102
Issue: 2
Pages: 245-256
ISSN: 1742-7835 (ISSN-L)
1742-7843
DOI: 10.1111/j.1742-7843.2007.00191.x
OpenAlex: W1564669788
Cited by: 257
References: 94
Citations by year: 2026: 5 · 2025: 9 · 2024: 4 · 2023: 6 · 2022: 9 · 2021: 12 · 2020: 17 · 2019: 16 · 2018: 19 · 2017: 16 · 2016: 16 · 2015: 16 · 2014: 14 · 2013: 28 · 2012: 23
FWCI: 2.04
Type: journal article
Language: en
Update notices: erratum (2009-10-13)
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Basic & Clinical Pharmacology & Toxicology (publishedVersion)
PubMed (publishedVersion)
Explore Bristol Research (submittedVersion)
Funders: Medical Research Council
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
Keywords: prenatal exposure, offspring outcomes, paternal exposure, confounding, birth cohort studies, Mendelian randomization, causal inference, intrauterine environment
MeSH terms: Female, Genotype, Humans, Male, Pregnancy, Prenatal Exposure Delayed Effects, Genetic Variation, Epidemiologic Studies, Maternal Exposure, Paternal Exposure

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Assessing Intrauterine Influences on Offspring Health Outcomes: Can Epidemiological Studies Yield Robust Findings?

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