The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Improvement of Sexual Function in Men with Late-Onset Hypogonadism Treated with Testosterone Only
Abstract
Aim: Late-onset hypogonadism is associated with relatively mild testosterone deficiencies. This study investigated the effects of restoring testosterone levels to normal in men with complaints of low sexual desire and erectile dysfunction. Main Outcome Measures: Sexual function was assessed with the International Index of Erectile Function (IIEF) at baseline and after 24 weeks of testosterone administration. Methods: Twenty-two hypogonadal men (mean age 58 years) with erectile dysfunction were studied. Fifteen patients had serum testosterone below 6.9 nmol/L, and seven between 7.2 and 11.7 nmol/L (reference values in our laboratory ≥12.0 nmol/L); there were considerable comorbidities. The duration of sexual complaints was on average 3.8 years. Patients received intramuscular long-acting testosterone undecanoate. Results: In all patients, serum testosterone levels were restored to normal within 6–8 weeks. Twelve patients reported a significant improvement in the sexual desire domain (from 4.5 to 8.4) and experienced an improvement in the erectile function domain (from 12 to 25 [Questions 1–5 plus 15)], following treatment with this long-acting testosterone; in 9 of 12 patients, this occurred only after at least 12–24 weeks. The remaining 10 patients reported an improvement of sexual desire (from 4.5 to 7.5), but no significant improvement in the erectile function domain (from 12 to 14). No changes in serum prostate-specific antigen or prostate volume were noticed while receiving this long-acting testosterone preparation. Conclusion: Restoring testosterone levels to normal in men with proven subnormal testosterone levels improves libido in most subjects, and erectile function in more than 50% of these men. It may take 12–24 weeks before the effects of testosterone become manifest.
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“Changes in erections/ejaculations may require up to 6 months.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [72]
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“Maximal effects are usually achieved after 3–6 months (72) but may take even up to 1 year in individual cases (71).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [72]
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Cites
Tramer, F., Caponecchia, L., Sgrò, P., Martinelli, M., Sandri, G., Panfili, E., Lenzi, A., & Gandini, L. (2004) · International Journal of Andrology · doi:10.1046/j.1365 · Cited by 1,686
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The endocrinology of sexual arousal
Bancroft, J. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06233 · Cited by 398
Aversa, A., Isidori, A. M., Spera, G., Lenzi, A., & Fabbri, A. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01764.x · Cited by 343
Effects of Castration and Androgen Replacement on Erectile Function in a Rabbit Model1
Traish, A. M., Park, K., Dhir, V., Kim, N. N., Moreland, R. B., & Goldstein, I. (1999) · Endocrinology · doi:10.1210/endo.140.4.6655 · Cited by 305
Azadzoi, K. M., Kim, N. N., Brown, M. L., Goldstein, I., Cohen, R. A., & de Tejada, I. S. (1992) · The Journal of Urology · doi:10.1016/s0022-5347(17)37201-4 · Cited by 220
Investigation, Treatment and Monitoring of Late-Onset Hypogonadism in Males
Nieschlag, E., Swerdloff, R. S., Hm, B., Gooren, L. J., Kaufman, J., Legros, J.-J., Lunenfeld, B., Morley, J. E., Schulman, C., Wang, C., et al. (2005) · European Urology · doi:10.1016/j.eururo.2005.04.027 · Cited by 201
Traish, A. M., & Guay, A. T. (2006) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2006.00245.x · Cited by 196
Schubert, M., Minnemann, T., Hübler, D., Rouskova, D., Christoph, A., Oettel, M., Ernst, M. E., Mellinger, U., Krone, W., & Jockenhövel, F. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0897 · Cited by 187
Kalinchenko, S. Y., Kozlov, G. I., Gontcharov, N. P., & Katsiya, G. V. (2003) · The Aging Male · doi:10.1080/tam.6.2.94.99 · Cited by 173
Research works printed but not linked: 1
- Yassin, 2005, Modulation of erectile function with long acting testosterone injection (Nebido) i.m. in hypogonadal patients, Int J Androl, 28, 63
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Onset of effects of testosterone treatment and time span until maximum effects are achieved
Saad, F., Aversa, A., Isidori, A. M., Zafalon, L., Zitzmann, M., & Gooren, L. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0221 · Cited by 232
Self-citationEndocrine Aspects of Male Sexual Dysfunctions
Buvat, J., Maggi, M., Gooren, L., Guay, A. T., Kaufman, J., Morgentaler, A., Schulman, C., Tan, H. M., Torres, L. O., Yassin, A., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01780.x · Cited by 221
Self-citationDifferent Testosterone Levels Are Associated with Ejaculatory Dysfunction
Corona, G., Jannini, E. A., Mannucci, E., Fisher, A. D., Lotti, F., Petrone, L., Balercia, G., Bandini, E., Chiarini, V., Forti, G., et al. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.00803.x · Cited by 164
Yassin, D., Doros, G. D., Hammerer, P. G., & Yassin, A. A. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12523 · Cited by 165
Self-citationSurampudi, P. N., Wang, C., & Swerdloff, R. S. (2012) · International Journal of Endocrinology · doi:10.1155/2012/625434 · Cited by 154
Metadata
- Authors
- Yassin, A. A., & Saad, F.
- Affiliations
- Gulf Medical University (AE)
- Corresponding author
- Yassin, Aksam A.
- Venue
- The Journal of Sexual Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-03-01
- Volume
- 4
- Issue
- 2
- Pages
- 497-501
- ISSN
- 1743-6095 (ISSN-L)
- 1743-6109
- OpenAlex
- W1936236392
- Cited by
- 101
- References
- 22
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 8 · 2012: 7
- FWCI
- 11.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- The Journal of Sexual Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- andropause, testosterone replacement therapy, testosterone undecanoate, erectile dysfunction, low libido, sexual desire, sexual function, International Index of Erectile Function, serum testosterone levels, prostate-specific antigen, prostate volume
- MeSH terms
- Adult, Aged, Dose-Response Relationship, Drug, Humans, Hypogonadism, Erectile Dysfunction, Libido, Male, Middle Aged, Penile Erection, Prospective Studies, Surveys and Questionnaires, Severity of Illness Index, Testosterone, Patient Satisfaction
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