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Cited by 101Hormonal and reproductive studiesSexual function and dysfunction studiesHypothalamic control of reproductive hormones

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Improvement of Sexual Function in Men with Late-Onset Hypogonadism Treated with Testosterone Only

Yassin, Aksam A., Saad, Farid·2007·The Journal of Sexual Medicine
DOI 10.1111/j.1743-6109.2007.00442.x
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Abstract

Aim: Late-onset hypogonadism is associated with relatively mild testosterone deficiencies. This study investigated the effects of restoring testosterone levels to normal in men with complaints of low sexual desire and erectile dysfunction. Main Outcome Measures: Sexual function was assessed with the International Index of Erectile Function (IIEF) at baseline and after 24 weeks of testosterone administration. Methods: Twenty-two hypogonadal men (mean age 58 years) with erectile dysfunction were studied. Fifteen patients had serum testosterone below 6.9 nmol/L, and seven between 7.2 and 11.7 nmol/L (reference values in our laboratory ≥12.0 nmol/L); there were considerable comorbidities. The duration of sexual complaints was on average 3.8 years. Patients received intramuscular long-acting testosterone undecanoate. Results: In all patients, serum testosterone levels were restored to normal within 6–8 weeks. Twelve patients reported a significant improvement in the sexual desire domain (from 4.5 to 8.4) and experienced an improvement in the erectile function domain (from 12 to 25 [Questions 1–5 plus 15)], following treatment with this long-acting testosterone; in 9 of 12 patients, this occurred only after at least 12–24 weeks. The remaining 10 patients reported an improvement of sexual desire (from 4.5 to 7.5), but no significant improvement in the erectile function domain (from 12 to 14). No changes in serum prostate-specific antigen or prostate volume were noticed while receiving this long-acting testosterone preparation. Conclusion: Restoring testosterone levels to normal in men with proven subnormal testosterone levels improves libido in most subjects, and erectile function in more than 50% of these men. It may take 12–24 weeks before the effects of testosterone become manifest.

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Crossref · 10.1111/j.1743-6109.2007.00442.x

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Research works printed but not linked: 1

  1. Yassin, 2005, Modulation of erectile function with long acting testosterone injection (Nebido) i.m. in hypogonadal patients, Int J Androl, 28, 63

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Metadata

Authors
Yassin, A. A., & Saad, F.
Affiliations
Gulf Medical University (AE)
Corresponding author
Yassin, Aksam A.
ORCID
Venue
The Journal of Sexual Medicine
Publisher
Oxford University Press (OUP)
Published
2007-03-01
Volume
4
Issue
2
Pages
497-501
ISSN
  • 1743-6095 (ISSN-L)
  • 1743-6109
DOI
10.1111/j.1743-6109.2007.00442.x
OpenAlex
W1936236392
Cited by
101
References
22
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 8 · 2012: 7
FWCI
11.45
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • The Journal of Sexual Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
andropause, testosterone replacement therapy, testosterone undecanoate, erectile dysfunction, low libido, sexual desire, sexual function, International Index of Erectile Function, serum testosterone levels, prostate-specific antigen, prostate volume
MeSH terms
Adult, Aged, Dose-Response Relationship, Drug, Humans, Hypogonadism, Erectile Dysfunction, Libido, Male, Middle Aged, Penile Erection, Prospective Studies, Surveys and Questionnaires, Severity of Illness Index, Testosterone, Patient Satisfaction

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