The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Serotonin Transporter Promoter Region (5-HTTLPR) Polymorphism is Associated with the Intravaginal Ejaculation Latency Time in Dutch Men with Lifelong Premature Ejaculation
Abstract
Introduction: Lifelong premature ejaculation (LPE) is characterized by persistent intravaginal ejaculation latency times (IELTs) of less than 1 minute, and has been postulated as a neurobiological dysfunction with genetic vulnerability for the short IELTs, related to disturbances of central serotonin (5-hydroxytryptamine [5-HT]) neurotransmission and 5-HT receptor functioning. Aim: To investigate the relationship between 5-HT transporter gene-linked polymorphism (5-HTTLPR) and short IELTs in men with lifelong PE. Methods: A prospective study was conducted in 89 Dutch Caucasian men with lifelong PE. IELT during coitus was assessed by stopwatch over a 1-month period. Controls consisted of 92 Dutch Caucasian men. All men with LPE were genotyped for a 5-HTT-promoter polymorphism. Allele frequencies and genotypes of short (S) and long (L) variants of 5-HTTLPR polymorphism were compared between patients and controls. Association between LL, SL, and SS genotypes, and the natural logarithm of the IELT in men with LPE was investigated. Main Outcome Measures: IELT measured by stopwatch, 5-HTTLPR polymorphism. Results: In men with lifelong PE, the geometric mean, median, and natural mean IELTs were 21, 26, and 32 seconds, respectively. There were no significant differences in the 5-HTT polymorphism alleles and genotypes between 89 Dutch Caucasian men with LPE (S 47%, L 53%/LL 29%, SL 48%, SS 22%) and 92 Dutch Caucasian controls (S 48%, L 52%/LL 29%, SL 45%, SS 26%). In men with lifelong PE there was a statistically significant difference between LL, SL, and SS genotypes in their geometric mean IELT (P ≤ 0.027); the LL genotypes had significantly shorter IELTs than the SS and SL genotypes. Conclusions: The 5-HTTLPR polymorphism is associated with significant effects on the latency to ejaculate in men with lifelong PE. Men with SS and SL genotypes have 100% and 90% longer ejaculation time, respectively than men with LL genotypes.
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Cites
Allelic Variation of Human Serotonin Transporter Gene Expression
Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D., & Lesch, K. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66062621.x · Cited by 2,221
Pattij, T., De Jong, T. R., Uitterdijk, A., Waldinger, M. D., Veening, J. G., Cools, A. R., Van Der Graaf, P. H., & Olivier, B. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04252.x · Cited by 163
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Cited by
Disorders of Orgasm and Ejaculation in Men
Rowland, D., McMahon, C. G., Abdo, C., Chen, J., Jannini, E., Waldinger, M. D., & Ahn, T. Y. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01782.x · Cited by 508
Self-citationAlthof, S. E., McMahon, C. G., Waldinger, M. D., Serefoglu, E. C., Shindel, A. W., Adaikan, P. G., Becher, E., Dean, J., Giuliano, F., Hellstrom, W. J. G., et al. (2014) · Sexual Medicine · doi:10.1002/sm2.28 · Cited by 444
Self-citationAlthof, S. E., Abdo, C. H. N., Dean, J., Hackett, G., McCabe, M., McMahon, C. G., Rosen, R. C., Sadovsky, R., Waldinger, M., Becher, E., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01975.x · Cited by 403
Self-citationAlthof, S. E., McMahon, C. G., Waldinger, M. D., Serefoglu, E. C., Shindel, A. W., Ganesan Adaikan, P., Becher, E., Dean, J., Giuliano, F., Hellstrom, W. J. G., et al. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12504 · Cited by 281
Self-citationSerotonin: A never-ending story
Olivier, B. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.10.031 · Cited by 253
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Metadata
- Authors
- Janssen, P. K. C., Bakker, S. C., Réthelyi, J., Zwinderman, A. H., Touw, D. J., Olivier, B., & Waldinger, M. D.
- Venue
- The Journal of Sexual Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-01-01
- Volume
- 6
- Issue
- 1
- Pages
- 276-284
- ISSN
- 1743-6095 (ISSN-L)
- 1743-6109
- OpenAlex
- W2046831345
- Cited by
- 215
- References
- 2
- FWCI
- 13.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Serotonin Transporter Promoter Region (5-HTTLPR) Polymorphism is Associated with the Intravaginal Ejaculation Latency Time in Dutch Men with Lifelong Premature Ejaculation. https://app.cochat.ai/papers/10.1111/j.1743-6109.2008.01033.x
- The paper
- Janssen, P. K. C., Bakker, S. C., Réthelyi, J., Zwinderman, A. H., Touw, D. J., Olivier, B., & Waldinger, M. D. (2009). Serotonin Transporter Promoter Region (5-HTTLPR) Polymorphism is Associated with the Intravaginal Ejaculation Latency Time in Dutch Men with Lifelong Premature Ejaculation. The Journal of Sexual Medicine. https://doi.org/10.1111/j.1743-6109.2008.01033.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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