Cited by 253Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchTreatment of Major Depression

Serotonin: A never-ending story

Open access
Olivier, Berend·2015·European Journal of Pharmacology

Abstract

The neurotransmitter serotonin is an evolutionary ancient molecule that has remarkable modulatory effects in almost all central nervous system integrative functions, such as mood, anxiety, stress, aggression, feeding, cognition and sexual behavior. After giving a short outline of the serotonergic system (anatomy, receptors, transporter) the author's contributions over the last 40 years in the role of serotonin in depression, aggression, anxiety, stress and sexual behavior is outlined. Each area delineates the work performed on animal model development, drug discovery and development. Most of the research work described has started from an industrial perspective, aimed at developing animals models for psychiatric diseases and leading to putative new innovative psychotropic drugs, like in the cases of the SSRI fluvoxamine, the serenic eltoprazine and the anxiolytic flesinoxan. Later this research work mainly focused on developing translational animal models for psychiatric diseases and implicating them in the search for mechanisms involved in normal and diseased brains and finding new concepts for appropriate drugs.

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Crossref · 10.1016/j.ejphar.2014.10.031

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262 of 262 references verified0 citation errors · 0 not checkable

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  • A contribution of specific 5-HT receptors to various adverse effects of SSRIs has been proposed, such as sexual dysfunction (5-HT1A) or a paradoxical anxiogenic response to subchronic SSRI treatment.

    “a contribution of specific 5-HT receptors to the various adverse effects of SSRIs has been proposed, such as for example sexual dysfunction [5-HT 1A ; (Olivier, 2015)] or a paradoxical anxiogenic response to subchronic SSRI treatment (Turcotte-Cardin et al., 2019).”

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Authors
Olivier, B.
Affiliations
Utrecht University (NL)
Corresponding author
Olivier, Berend
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
2015-04
Volume
753
Pages
2-18
ISSN
0014-2999 (ISSN-L)
OpenAlex
W2047969260
Cited by
253
References
262
Citations by year
2026: 11 · 2025: 22 · 2024: 21 · 2023: 21 · 2022: 17 · 2021: 22 · 2020: 31 · 2019: 23 · 2018: 22 · 2017: 26 · 2016: 22 · 2015: 15
FWCI
2.39
Type
journal article
Language
en
Open access
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
serotonin, serotonergic system, serotonin receptors, serotonin transporter, depression, aggression, anxiety, stress, sexual behavior, fluvoxamine, eltoprazine, flesinoxan, selective serotonin reuptake inhibitors, translational research
MeSH terms
Aggression, Animals, Anxiety, Depression, Humans, Psychotropic Drugs, Serotonin, Sexual Behavior, Animal

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