Serotonin: A never-ending story
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The neurotransmitter serotonin is an evolutionary ancient molecule that has remarkable modulatory effects in almost all central nervous system integrative functions, such as mood, anxiety, stress, aggression, feeding, cognition and sexual behavior. After giving a short outline of the serotonergic system (anatomy, receptors, transporter) the author's contributions over the last 40 years in the role of serotonin in depression, aggression, anxiety, stress and sexual behavior is outlined. Each area delineates the work performed on animal model development, drug discovery and development. Most of the research work described has started from an industrial perspective, aimed at developing animals models for psychiatric diseases and leading to putative new innovative psychotropic drugs, like in the cases of the SSRI fluvoxamine, the serenic eltoprazine and the anxiolytic flesinoxan. Later this research work mainly focused on developing translational animal models for psychiatric diseases and implicating them in the search for mechanisms involved in normal and diseased brains and finding new concepts for appropriate drugs.
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A contribution of specific 5-HT receptors to various adverse effects of SSRIs has been proposed, such as sexual dysfunction (5-HT1A) or a paradoxical anxiogenic response to subchronic SSRI treatment.
“a contribution of specific 5-HT receptors to the various adverse effects of SSRIs has been proposed, such as for example sexual dysfunction [5-HT 1A ; (Olivier, 2015)] or a paradoxical anxiogenic response to subchronic SSRI treatment (Turcotte-Cardin et al., 2019).”
From Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders (2019) · cites this paper as Olivier, 2015
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- Authors
- Olivier, B.
- Affiliations
- Utrecht University (NL)
- Corresponding author
- Olivier, Berend
- ORCID
- Olivier, Berend
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 753
- Pages
- 2-18
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2047969260
- Cited by
- 253
- References
- 262
- Citations by year
- 2026: 11 · 2025: 22 · 2024: 21 · 2023: 21 · 2022: 17 · 2021: 22 · 2020: 31 · 2019: 23 · 2018: 22 · 2017: 26 · 2016: 22 · 2015: 15
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- green
- dspace.library.uu.nl
- Licence
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- serotonin, serotonergic system, serotonin receptors, serotonin transporter, depression, aggression, anxiety, stress, sexual behavior, fluvoxamine, eltoprazine, flesinoxan, selective serotonin reuptake inhibitors, translational research
- MeSH terms
- Aggression, Animals, Anxiety, Depression, Humans, Psychotropic Drugs, Serotonin, Sexual Behavior, Animal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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