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Cited by 35Sexual function and dysfunction studiesUrinary Bladder and Prostate ResearchHormonal and reproductive studies

Effects of oral finasteride on erectile function in a rat model

Zhang, Min-Guang, Wu, Wei, Zhang, Cun-Ming, Wang, Xian-Jin, Gao, Ping-Jin, Lu, Ying-Li, Shen, Zhou-Jun·2012·The Journal of Sexual Medicine
DOI 10.1111/j.1743-6109.2012.02661.x
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Abstract

Introduction: Many clinical studies reported finasteride-related erectile dysfunction, but to date, few animal experiments have focused on it. Aim: To investigate the effects of oral finasteride on erectile function in a rat model. Main Outcome Measures: Erectile responses and morphological changes. Methods: Adult, male Sprague-Dawley rats were divided into four groups (25/group): (i) control; (ii) castration; (iii) castration with testosterone (T) replacement; and (iv) oral finasteride treatment. Four weeks later, erectile function was measured by the ratio of intracavernosal pressure and mean arterial blood pressure upon electrical stimulation of the cavernous nerve. Serum T and dihydrotestosterone (DHT) and intraprostatic DHT were measured. The weights and histopathological features of the penile corpus cavernosum and prostate were examined. Results: Serum T and DHT and intraprostatic DHT concentrations, erectile function, and mean weights of the corpus cavernosum and prostate were lowest in group 2. There was no significant difference in the serum T concentration and erectile function between groups 4 and 1. However, the serum and intraprostatic DHT concentrations were significantly lower in group 4 than in group 1 (both P < 0.001). The tissue weights of the corpus cavernosum and prostate were reduced by 25.9% and 92.3% in group 4 compared with group 1 (both P < 0.001). Histopathology revealed a significant atrophy of the prostate in groups 2 and 4. There was a significant decrease in the smooth muscle content in group 2, but not in groups 3 and 4. Conclusions: In a rat model, finasteride treatment for 4 weeks reduces the weight of the corpus cavernosum but appears not to affect the erectile responses to electrical stimulation of the cavernous nerve. As erection is a complex process involving important signaling in the brain, further studies are necessary to demonstrate the long-term effects of finasteride on both central and peripheral neural pathways of erection.

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Authors
Zhang, M.-G., Wu, W., Zhang, C.-M., Wang, X.-J., Gao, P.-J., Lu, Y.-L., & Shen, Z.-J.
Affiliations
  • Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China
  • Shanghai Jiao Tong University (CN)
  • Department of Hypertension, Ruijin Hospital, Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine , Shanghai , China
  • Shanghai Jiao Tong University School of Medicine , Shanghai , China
ORCID
Wu, Wei
Venue
The Journal of Sexual Medicine
Publisher
Oxford University Press (OUP)
Published
2012-05-01
Volume
9
Issue
5
Pages
1328-1336
ISSN
  • 1743-6095 (ISSN-L)
  • 1743-6109
DOI
10.1111/j.1743-6109.2012.02661.x
OpenAlex
W2158665393
Cited by
35
References
29
Citations by year
2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 6 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 2
FWCI
2.97
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • The Journal of Sexual Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (30872576)
  • Shanghai Science and Technology Commission (09DJ1400402)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
finasteride, erectile dysfunction, erectile function, corpus cavernosum, dihydrotestosterone, testosterone replacement therapy, castration, prostate atrophy, intracavernous pressure, prostate histopathology
MeSH terms
Administration, Oral, Animals, Disease Models, Animal, Erectile Dysfunction, Male, Penile Erection, Penis, Prostate, Dihydrotestosterone, Testosterone, Rats, Sprague-Dawley, Finasteride, Rats, 5-alpha Reductase Inhibitors

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