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Cited by 93Marine Invertebrate Physiology and EcologyMarine Sponges and Natural ProductsDevelopmental Biology and Gene Regulation

Evolutionary emergence of synaptic nervous systems: what can we learn from the non‐synaptic, nerveless Porifera?

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Nickel, Michael·2010·Invertebrate Biology
DOI 10.1111/j.1744-7410.2010.00193.x
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Abstract

Abstract.The Porifera represent one of the only two recent nerveless and muscleless metazoan phyla. Nevertheless, sponges provide behavioral, physiological, pharmacological, morphological, and, more recently, an increasing amount of genetic evidence for a paracrine pre‐nervous integration system. Although this system might be derived, it allows us to draw conclusions, on the basis of comparative data, about the origin of the nervous systemsensu strictoas found in the eumetazoan phyla. The goal of the present review is to compile recent evidence on the sponge integration systems. Based on this framework, new light is also shed on the evolutionary origin of the eumetazoan synaptic nervous systems, which can be regarded to form an evolutionary biochemical continuum with the paracrine signaling system in sponges. Thus, we can assume that the evolutionary transition from a paracrine‐dominated, pre‐nervous system to an electrochemically dominated, primordial nervous system resulted in part from compartmentalization effects. As intermediate evolutionary stages, regionalized synapse precursor areas might have occurred within pre‐nervous cells, which foreshadowed the highly organized synaptic scaffolds present in recent nerve cells of the Eumetazoa.

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  • The first synapse arose from the aggregation of vesicle-related intercellular signalling modules, including synaptotagmin, SNARE-complex components and postsynaptic receptor complexes.

    “Similar ideas have been put forward repeatedly [5,66,67] and imply that the first synapse arose from the aggregation of vesicle-related intercellular signalling modules, including synaptotagmin, SNARE-complex components and postsynaptic receptor complexes, as extensively reviewed elsewhere [15,32,34,46,60].”

    From Gastric pouches and the mucociliary sole: setting the stage for nervous system evolution (2015) · cites this paper as [60]

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Research works printed but not linked: 26

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Authors
Nickel, M.
Affiliations
Friedrich Schiller University Jena (DE)
Corresponding author
Nickel, Michael
ORCID
Nickel, Michael
Venue
Invertebrate Biology
Publisher
Wiley
Published
2010-02
Volume
129
Issue
1
Pages
1-16
ISSN
  • 1077-8306 (ISSN-L)
  • 1744-7410
DOI
10.1111/j.1744-7410.2010.00193.x
OpenAlex
W2061016427
Cited by
93
References
9
Citations by year
2025: 1 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 11 · 2018: 6 · 2017: 7 · 2016: 7 · 2015: 8 · 2014: 7 · 2013: 5 · 2012: 2
FWCI
4.29
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 31 d)
Locations
  • Invertebrate Biology (publishedVersion)
  • Helmholtz Centre for Ocean Research Kiel (GEOMAR) (acceptedVersion)
  • DESY Publication Database (PUBDB) (Deutsches Elektronen-Synchrotron) (submittedVersion, other-oa)
Topics
  • Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
sponges, paracrine signaling, compartmentalization

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