The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Role of Megalin and Cubilin in the Metabolism of Vitamin D3
Abstract
Vitamin D deficiency is associated with various medical conditions including musculoskeletal disorders, infection, metabolic diseases, and cardiovascular disease. Megalin and cubilin, endocytic receptors in proximal tubule cells, are involved in the reabsorption of vitamin D binding protein from glomerular filtrates and the subsequent intracellular conversion of 25‐hydroxyvitamin D 3 to biologically active 1α,25‐dihydroxyvitamin D 3. Dysfunction of these receptors, which is commonly found in patients with diabetic nephropathy, even at early stages, may explain why vitamin D deficiency is often complicated in these patients. Therapeutic strategies to protect the functions of these receptors from injury could be used to prevent vitamin D deficiency and its related disorders.
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“While not applicable to T and SHBG, megalin- and cubilin-mediated endocytosis is, however, relevant in vitamin D metabolism. Being mainly expressed on the luminal brush border membrane of the renal proximal convoluted tubule, megalin and cubilin bind and reabsorb the vitamin D–DBP complex from the glomerular ultrafiltrate, hereby preventing uncontrolled loss of vitamin D metabolites in urine.”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [36]
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Cites
Overview of general physiologic features and functions of vitamin D
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An Endocytic Pathway Essential for Renal Uptake and Activation of the Steroid 25-(OH) Vitamin D3
Nykjaer, A., Dragun, D., Walther, D., Vorum, H., Jacobsen, C., Herz, J., Melsen, F., Christensen, E. I., & Willnow, T. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80655-8 · Cited by 1,027
The Free Hormone Hypothesis: A Physiologically Based Mathematical Model*
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de Zeeuw, D., Agarwal, R., Amdahl, M., Audhya, P., Coyne, D., Garimella, T., Parving, H.-H., Pritchett, Y., Remuzzi, G., Ritz, E., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61032-x · Cited by 695
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Self-citationOsteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein
Safadi, F. F., Thornton, P., Magiera, H., Hollis, B. W., Gentile, M., Haddad, J. G., Liebhaber, S. A., & Cooke, N. E. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5244 · Cited by 402
Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D 3
Nykjaer, A., Fyfe, J. C., Kozyraki, R., Leheste, J.-R., Jacobsen, C., Nielsen, M. S., Verroust, P. J., Aminoff, M., de la Chapelle, A., Moestrup, S. K., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241516998 · Cited by 325
Cited by
The roles of vitamin D in skeletal muscle: form, function, and metabolism
Girgis, C. M., Clifton-Bligh, R. J., Hamrick, M. W., Holick, M. F., & Gunton, J. E. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1012 · Cited by 567
Narinx, N., David, K., Walravens, J., Vermeersch, P., Claessens, F., Fiers, T., Lapauw, B., Antonio, L., & Vanderschueren, D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04562-1 · Cited by 96
Metadata
- Authors
- Kaseda, R., Hosojima, M., Sato, H., & Saito, A.
- Affiliations
- Niigata University (JP)
- Corresponding author
- Saito, Akihiko
- Venue
- Therapeutic Apheresis and Dialysis
- Publisher
- Wiley
- Published
- 2011-05-19
- Volume
- 15
- Issue
- s1
- Pages
- 14-17
- ISSN
- 1091-6660 (ISSN-L)
- 1744-9979
- 1744-9987
- OpenAlex
- W1586316986
- Cited by
- 66
- References
- 25
- Citations by year
- 2025: 1 · 2024: 6 · 2023: 2 · 2022: 8 · 2021: 3 · 2020: 6 · 2019: 8 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 6 · 2012: 6
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Therapeutic Apheresis and Dialysis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- megalin, cubilin, vitamin D3 metabolism, vitamin D deficiency, 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3, proximal tubule, diabetic nephropathy, endocytic receptor, renal vitamin D metabolism
- MeSH terms
- Animals, Calcifediol, Calcitriol, Diabetic Nephropathies, Humans, Receptors, Cell Surface, Vitamin D Deficiency, Low Density Lipoprotein Receptor-Related Protein-2
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- CoChat. (2026). Citation check: Role of Megalin and Cubilin in the Metabolism of Vitamin D3. https://app.cochat.ai/papers/10.1111/j.1744-9987.2011.00920.x
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- Kaseda, R., Hosojima, M., Sato, H., & Saito, A. (2011). Role of Megalin and Cubilin in the Metabolism of Vitamin D3. Therapeutic Apheresis and Dialysis. https://doi.org/10.1111/j.1744-9987.2011.00920.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
