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Cited by 43Cardiovascular and exercise physiologyMuscle metabolism and nutritionAdipose Tissue and Metabolism

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

FREE FATTY ACID TURNOVER AND THE AVAILABILITY OF SUBSTRATES AS A LIMITING FACTOR IN PROLONGED EXERCISE

Gollnick, Philip D.·1977·Annals of the New York Academy of Sciences
DOI 10.1111/j.1749-6632.1977.tb38186.x
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Abstract

A continual hydrolysis and release of FFA from the triglycerides stores of adipose tissue occurs during prolonged moderately severe exercise. The uptake and oxidation of plasma FFA by the working skeletal muscles represents a major source of energy during such exercise. During light and moderately intense prolonged exercise, lipolysis and the release of FFA from the adipose tissue exceeds uptake by peripheral tissue and the net result is an increase in plasma FFA levels. FFA uptake appears to be related to plasma concentrations and uses no membrane transport system. As work intensity increases the release of FFA from adipose tissue declines and the relative contribution of the plasma FFA to the work metabolism declines until at high work rates there is an almost complete reliance on the intramuscular glycogen reserves. At work loads above about 65% of the individual's aerobic capacity the limiting factor for prolonged exercise appears to be the glycogen stores of the working muscle. When these stores are depleted the work either must stop or its intensity be reduced. Trained individuals have a greater capacity to oxidize fats at high work loads than do untrained subjects. This, however, is not matched by an increased capacity for lipolysis. Why intramuscular glycogen stores are required for prolonged relatively severe exercise when the amount of FFA and glucose that perfuses the skeletal muscles under such conditions is theoretically capable of supporting the exercise metabolism is unknown.

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Crossref · 10.1111/j.1749-6632.1977.tb38186.x

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Citations

Cites

Research works printed but not linked: 5

  1. Pettenkofer M., 1866, Untersuchungen ueber dem Stoffverbrauch des normalen Menschen, Z. Biol., 2, 459
  2. Chauveau A., 1896, Source et nature du potentiel directment utilise dans le travail musculaire d'après les exchanges respiratoires, chez l'homme en etat d'abstinence, C.R. Acad. Sci. (Paris)., 122, 1163
  3. Anderson R. J., 1917, The interrelation between diet and body condition and the energy production during mechanical work, J. Biol. Chem., 32, 421
  4. Szent‐Györgyi A., 1924, Die quantitative Bestimmung der freien Blut fettsäuren, Biochem. Z., 146, 226
  5. Saltin B. B.Essén E.Jansson P. D.Gollnick&B.PernowAvailability of substrates and leg metabolism during exercise in man. In Press.

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Metadata

Authors
Gollnick, P. D.
Affiliations
Washington State University (US)
Corresponding author
Gollnick, Philip D.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
1977-10
Volume
301
Issue
1
Pages
64-71
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1111/j.1749-6632.1977.tb38186.x
OpenAlex
W1968026328
Cited by
43
References
51
Citations by year
2016: 1
FWCI
0.07
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 10668 d)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords
free fatty acid turnover, prolonged exercise, lipolysis, adipose tissue, plasma free fatty acids, fatty acid oxidation, skeletal muscle, substrate availability, exercise metabolism, trained vs untrained subjects, energy substrate utilization
MeSH terms
Adipose Tissue, Diet, Physical Exertion, Fatty Acids, Nonesterified, Glucose, Glycogen, Humans, Lipid Mobilization, Muscles, Sports Medicine

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