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Cited by 37Estrogen and related hormone effectsBreast Cancer Treatment StudiesSteroid Chemistry and Biochemistry

Uptake and concentration of steroid hormones in mammary tissues.

THIJSSEN, J. H. H., LANDEGHEM, A. A. J. VAN, POORTMAN, J.·1986·Annals of the New York Academy of Sciences
DOI 10.1111/j.1749-6632.1986.tb15998.x
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Abstract

In order to exert their biological effects, steroid hormones must enter the cells of target tissues and after binding to specific receptor molecules must remain for a prolonged period of time in the nucleus. Therefore the endogenous levels and the subcellular distribution of estradiol, estrone, DHEAS, DHEA ad 5-Adiol were measured in normal breast tissues and in malignant and nonmalignant breast tumors from pre- and postmenopausal women. For estradiol the highest tissue levels were found in the malignant samples. No differences were seen in these levels between pre- and postmenopausal women despite the largely different peripheral blood levels. For estrone no differences were found between the tissues studied. Although the estradiol concentration was higher in the estradiol-receptor-positive than in the receptor-negative tumors, no correlation was calculated between the estradiol and the receptor consent. Striking differences were seen between the breast and uterine tissues for the total tissue concentration of estradiol, the ratio between estradiol and estrone, and the subcellular distribution of both estrogens. At similar receptor concentrations in the tissues these differences cannot easily be explained. Regarding the androgens, the tissue/plasma gradient was higher for DHEA than for 5-Adiol, and for DHEAS there was very probably a much lower tissue gradient. The highly significant correlation between the androgens suggests an intracellular metabolism of DHEAS to DHEA and 5-Adiol. Lower concentrations of DHEAS and DHEA were observed in the malignant tissues compared with the normal ones and the benign lesions. For 5-Adiol no differences were found and therefore these data do not support our original hypothesis on the role of this androgen in the etiology of breast abnormalities. Hence the way in which adrenal androgens express their influence on the breast cells remains unclear.

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Crossref · 10.1111/j.1749-6632.1986.tb15998.x

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Authors
THIJSSEN, J. H. H., LANDEGHEM, A. A. J. V., & POORTMAN, J.
Affiliations
University Medical Center Utrecht (NL)
ORCID
THIJSSEN, J. H. H.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
1986-06
Volume
464
Issue
1
Pages
106-116
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1111/j.1749-6632.1986.tb15998.x
OpenAlex
W2054286532
Cited by
37
References
42
Citations by year
2018: 1 · 2015: 1
FWCI
1.01
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7503 d)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
Keywords
breast tissue, breast cancer, estradiol, estrone, dehydroepiandrosterone sulfate, dehydroepiandrosterone, 5-androstenediol, androgens, estrogen receptor, subcellular localization, menopause, uterine tissue, adrenal androgens, breast abnormalities
MeSH terms
Adult, Androgens, Biopsy, Breast, Breast Diseases, Breast Neoplasms, Cell Nucleus, Cytosol, Dehydroepiandrosterone, Epidemiologic Methods, Estradiol, Estrone, Female, Humans, Menopause, Middle Aged, Androstenediol, Dehydroepiandrosterone Sulfate

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